Zobrazeno 1 - 10
of 20
pro vyhledávání: '"R Brent Calder"'
Autor:
Esther R Berko, Masako Suzuki, Faygel Beren, Christophe Lemetre, Christine M Alaimo, R Brent Calder, Karen Ballaban-Gil, Batya Gounder, Kaylee Kampf, Jill Kirschen, Shahina B Maqbool, Zeineen Momin, David M Reynolds, Natalie Russo, Lisa Shulman, Edyta Stasiek, Jessica Tozour, Maria Valicenti-McDermott, Shenglong Wang, Brett S Abrahams, Joseph Hargitai, Dov Inbar, Zhengdong Zhang, Joseph D Buxbaum, Sophie Molholm, John J Foxe, Robert W Marion, Adam Auton, John M Greally
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004402 (2014)
DNA mutational events are increasingly being identified in autism spectrum disorder (ASD), but the potential additional role of dysregulation of the epigenome in the pathogenesis of the condition remains unclear. The epigenome is of interest as a pos
Externí odkaz:
https://doaj.org/article/a803dd8795744243ae732bdcac7b9739
Publikováno v:
PLoS Genetics, Vol 6, Iss 5, p e1000950 (2010)
Using a transgenic mouse model harboring a mutation reporter gene that can be efficiently recovered from genomic DNA, we previously demonstrated that mutations accumulate in aging mice in a tissue-specific manner. Applying a recently developed, simil
Externí odkaz:
https://doaj.org/article/1e56480a6c9642449be9617694744374
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 772:55-62
Recently, great progress has been made in single cell genomics and transcriptomics. Here, we present an integrative method, termed single-cell transcriptogenomics (SCTG), in which whole exome sequencing and RNA-seq is performed concurrently on single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9775098efcf9d1c15938fd4a869b9c11
Autor:
R Brent Calder1 bcalder@buckinstitute.org, Beems, Rudolf B2 r.beems@rivm.nl, van Steeg, Harry2 h.van.steeg@rivm.nl, Mian, I Saira1,3 smian@lbl.gov, Lohman, Paul HM2 lohmanp@xs4all.nl, Vijg, Jan1 jvijg@buckinstitute.org
Publikováno v:
BMC Bioinformatics. 2007, Vol. 8, p183-9. 9p. 4 Color Photographs, 4 Diagrams.
Autor:
Masako Suzuki, Andrew S McLellan, Robert A. Dubin, John M. Greally, Joseph Hargitai, R. Brent Calder, Aaron Golden, Qiang Jing, Pilib Ó Broin, David Moskowitz
Publikováno v:
Genomics. 100:345-351
The challenges associated with the management, analysis and interpretation of assays based on massively-parallel sequencing (MPS) are both individually complex and numerous. We describe what we believe to be the appropriate solution, one that represe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c1f6f46fc171d1385e4adf782487f6
https://doi.org/10.1016/j.ygeno.2012.08.005
https://doi.org/10.1016/j.ygeno.2012.08.005
Autor:
Jan Vijg, Gary B. Chisholm, Rumana Bahar, R. Brent Calder, Martijn E.T. Dollé, Bradley H Pollock, Ashley D. Denny, Rita A. Busuttil, Christoph Klein, Claudia H. Hartmann, Karl A. Rodriguez
Publikováno v:
Nature. 441:1011-1014
The accumulation of somatic DNA damage has been implicated as a cause of ageing in metazoa. One possible mechanism by which increased DNA damage could lead to cellular degeneration and death is by stochastic deregulation of gene expression. Here we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8330f45569721fac4c2c20d995dfa1
https://doi.org/10.1038/nature04844
https://doi.org/10.1038/nature04844
Autor:
Ernesto Perez, Jan Vijg, Linda V. Chadwell, Anastasia Derventzi, R. Brent Calder, Ana Maria Garcia, Martha J. Lundell, Rita A. Busuttil, Martijn E.T. Dollé
Publikováno v:
Nature Methods. 4:401-403
Presently there are no good assays for comparing somatic mutation frequencies and spectra between different vertebrate and invertebrate organisms. Here we describe a new lacZ mutation reporter system in D. melanogaster, which complements existing sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8f56fe8bda83d00a2fd3ff31d820d1
https://doi.org/10.1038/nmeth1027
https://doi.org/10.1038/nmeth1027
Autor:
R. Brent Calder, Monica Chung, Enver Akalin, Nicole Hayde, James Pullman, Graciela de Boccardo, Yi Bao, Bin Ye, Daniel Schwartz, Michelle Lubetzky, Maria Ajaimy
This study investigated the mechanisms involved in development of donor-specific antibody (DSA) and/or C4d-negative transplant glomerulopathy (TGP) by allograft gene expression profiles using microarrays.This cohort study was conducted in kidney tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5cd32042f0c9e8145ec161ef51b82f5
https://europepmc.org/articles/PMC3848403/
https://europepmc.org/articles/PMC3848403/
Publikováno v:
XSEDE
The use of sequencing technologies has revolutionized the field of genomics, allowing us to study structural and functional variations within the genome to base pair level. These technologies can also be used to probe the associated epigenome, where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f552286dd2aabf6dd1c4aa613338c47
https://doi.org/10.1145/2484762.2484812
https://doi.org/10.1145/2484762.2484812
Autor:
Aaron, Golden, Andrew S, McLellan, Robert A, Dubin, Qiang, Jing, Pilib, O Broin, David, Moskowitz, Zhengdong, Zhang, Masako, Suzuki, Joseph, Hargitai, R Brent, Calder, John M, Greally
Publikováno v:
Studies in health technology and informatics. 175
Massively-parallel sequencing (MPS) technologies and their diverse applications in genomics and epigenomics research have yielded enormous new insights into the physiology and pathophysiology of the human genome. The biggest hurdle remains the magnit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e2b606e929270b395eff07b3490addc
https://pubmed.ncbi.nlm.nih.gov/22942009
https://pubmed.ncbi.nlm.nih.gov/22942009