Interleukin-17A Is Produced by CD4+ but Not CD8+ T Cells in Synovial Fluid Following T Cell Receptor Activation and Regulates Different Inflammatory Mediators Compared to Tumor Necrosis Factor in a Model of Psoriatic Arthritis Synovitis

Autor: Dominique Baeten, Patrick S. Asmawidjaja, Johanna M. W. Hazes, R Bisoendial, X Xu, Erik Lubberts, Anne-Marie Mus, Errol P. Prens, Nadine Davelaar, Marijn Vis

Publikováno v: Arthritis & Rheumatology (Hoboken, N.j.)
Arthritis & rheumatology (Hoboken, N.J.), 72(8), 1303-1313. John Wiley and Sons Ltd
Arthritis and Rheumatology, 72(8), 1303-1313. John Wiley & Sons Ltd.

Objective: Interleukin-17A (IL-17A) and tumor necrosis factor (TNF) contribute to the pathogenesis of psoriatic arthritis (PsA). However, their functional relationship in PsA synovitis has not been fully elucidated. Additionally, although CD8+ T cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd90ea574eafee4f02f40b79cf3a766
http://www.scopus.com/inward/record.url?scp=85087625133&partnerID=8YFLogxK

C-Reactive Protein Promotes Inflammation through Fc gamma R-Induced Glycolytic Reprogramming of Human Macrophages

Autor: Alwin J. van der Ham, Lathees Sritharan, Willianne Hoepel, Jeroen den Dunnen, Dominique Baeten, Leonie de Boer, Melissa Newling, Bart Everts, Sebastian A. J. Zaat, R Bisoendial, Renée H. Fiechter

Publikováno v: Journal of Immunology, 203(1), 225-235. AMER ASSOC IMMUNOLOGISTS
Journal of immunology (Baltimore, Md., 203(1), 225-235. American Association of Immunologists

C-reactive protein (CRP) is an acute-phase protein produced in high quantities by the liver in response to infection and during chronic inflammatory disorders. Although CRP is known to facilitate the clearance of cell debris and bacteria by phagocyti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d2ed83a81c3ff564aaecdb7876ea86
https://hdl.handle.net/1887/122194

P093 Distinct and overlapping activities of IL-17A and TNF on the expression of proinflammatory cytokines and MMPS in psoriatic arthritis: rationale for ANTI-IL-17A/ANTI-TNFALPHA combination therapy?

Autor: J. M. W. Hazes, R Bisoendial, Patrick S. Asmawidjaja, X Xu, Marijn Vis, Dominique Baeten, Erik Lubberts, A-M Otten-Mus, Nadine Davelaar

Publikováno v: Poster presentations.

Introduction TNF and IL-17A are proinflammatory cytokines critically involved in the pathogenesis of psoriatic arthritis (PsA). Currently, targeting TNF is the first choice of a biologic disease-modifying antirheumatic drug (bDMARD) in PsA. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1264258ba4b9fc1b45d00232859ca364
https://doi.org/10.1136/annrheumdis-2018-ewrr2018.109

AB0118 The lymphatic system: a gatekeeper for migration of pathogenic t-cells towards synovial joints and entheses in psoriasis

Autor: Nadine Davelaar, PS Asmawidjaja, Johanna Mw Hazes, R Bisoendial, Arien Hofman, E Lubberts, Errol P. Prens, Adriana M.C. Mus, Marc R. Kok, Jean-Bart Jaquet

Publikováno v: Abstracts Accepted for Publication.

Background The factors underlying the transition of psoriasis (PsO) to psoriatic arthritis (PsA) are poorly understood. The lymphatic system may control the homing of disease-associated T-cells to skin and extra-cutaneous sites like synovial joints a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20e69ae0badb8bdd3979953948b10ea9
https://doi.org/10.1136/annrheumdis-2017-eular.5360

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