Zobrazeno 1 - 10
of 189
pro vyhledávání: '"R Bally"'
Autor:
Michael D. Powell, Peiyuan Lu, Dennis K. Neeld, Anna K. Kania, Lou-Ella M. M. George-Alexander, Alexander P. R. Bally, Christopher D. Scharer, Jeremy M. Boss
Publikováno v:
ImmunoHorizons. 6:872-882
CD8 cytotoxic T cells are a potent line of defense against invading pathogens. To aid in curtailing aberrant immune responses, the activation status of CD8 T cells is highly regulated. One mechanism in which CD8 T cell responses are dampened is via s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33cf5c8172df583c388c40cdfeda14a
https://doi.org/10.4049/immunohorizons.2100112
https://doi.org/10.4049/immunohorizons.2100112
Autor:
Benjamin G. Barwick, Christopher D. Scharer, Ryan J. Martinez, Madeline J. Price, Alexander N. Wein, Robert R. Haines, Alexander P. R. Bally, Jacob E. Kohlmeier, Jeremy M. Boss
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
DNA methylation is known to contribute to B cell differentiation, but de novo methylation has not been studied in this context. Here the authors use a conditional Dnmt3a/b knockout mouse to map the function of de novo DNA methylation in B cell differ
Externí odkaz:
https://doaj.org/article/33af14121bb04d5cbdd45624b424b0e7
Autor:
Christopher D. Scharer, Benjamin G. Barwick, Muyao Guo, Alexander P. R. Bally, Jeremy M. Boss
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
During B cell differentiation, the role of different genomic loci in transcriptional and epigenetic regulation in vivo is not well defined. Here the authors use an in vivo B cell differentiation model to map cellular division-dependent cis-regulatory
Externí odkaz:
https://doaj.org/article/ce454525ef924494b954d29152418aee
Autor:
Christopher D. Scharer, Alexander P. R. Bally, Dillon G. Patterson, Parimal Majumder, Jeremy M. Boss, Joshua T. Lee, Benjamin G. Barwick
Publikováno v:
J Immunol
In both humans and mice, CTCF-binding elements form a series of interacting loops across the MHC class II (MHC-II) locus, and CTCF is required for maximal MHC-II gene expression. In humans, a CTCF-bound chromatin insulator termed XL9 and a super enha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987d964d0da701a627f41f74bcd2da7a
https://doi.org/10.4049/jimmunol.2001089
https://doi.org/10.4049/jimmunol.2001089
Autor:
Bhrugu Yagnik, Kristen N. Morrow, Shelly Wang, Thomas H. Vanderford, Alexander P. R. Bally, Gordon J. Freeman, Sheikh Abdul Rahman, Rama Rao Amara, Rafi Ahmed
Publikováno v:
Sci Immunol
During antiretroviral therapy (ART), most of the human immunodeficiency virus (HIV) reservoirs persist in the B cell follicles (BCFs) of lymphoid tissue. Thus, for HIV cure strategies, it is critical to generate cytolytic CD8+ T cells that home to BC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755283012d0a138a711642048d940f6d
https://europepmc.org/articles/PMC8500359/
https://europepmc.org/articles/PMC8500359/
Autor:
Muyao Guo, Alexander P. R. Bally, Christopher D. Scharer, Jeremy M. Boss, Benjamin G. Barwick
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
The genomic loci associated with B cell differentiation that are subject to transcriptional and epigenetic regulation in vivo are not well defined, leaving a gap in our understanding of the development of humoral immune responses. Here, using an in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264d6ce5d4619d65bf911ded128d4748
https://doaj.org/article/ce454525ef924494b954d29152418aee
https://doaj.org/article/ce454525ef924494b954d29152418aee
Publikováno v:
The Journal of Immunology. 198:2238-2243
CD8 T cell memory is characterized by rapid recall of effector function, increased proliferation, and reduced activation requirements. Despite the extensive functional characterization, the molecular mechanisms that facilitate these enhanced properti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5140381ef993995c63f73203c66b53be
https://doi.org/10.4049/jimmunol.1602086
https://doi.org/10.4049/jimmunol.1602086
Autor:
Joshua T. Lee, Brian D. Evavold, Ryan J. Martinez, Alexander P. R. Bally, Benjamin G. Barwick, Yan Tang, Jeremy M. Boss
Publikováno v:
The Journal of Immunology. 198:205-217
Expression of programmed death 1 (PD-1) on CD8 T cells promotes T cell exhaustion during chronic Ag exposure. During acute infections, PD-1 is transiently expressed and has the potential to modulate CD8 T cell memory formation. Conserved region C (CR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b77b99697e6cabd1be90c4fb0e06f020
https://doi.org/10.4049/jimmunol.1601464
https://doi.org/10.4049/jimmunol.1601464
Autor:
Alexander P. R. Bally, Jeremy M. Boss, Peiyuan Lu, Parimal Majumder, Yan Tang, Benjamin G. Barwick, Qing Wang, Dennis K. Neeld
Publikováno v:
J Immunol
During prolonged exposure to Ags, such as chronic viral infections, sustained TCR signaling can result in T cell exhaustion mediated in part by expression of programmed cell death–1 (PD-1) encoded by the Pdcd1 gene. In this study, dynamic changes i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cafacd5d550ebbb592b37909bc1d623
https://pubmed.ncbi.nlm.nih.gov/31811020
https://pubmed.ncbi.nlm.nih.gov/31811020
Autor:
Peiyuan Lu, Benjamin G. Barwick, Parimal Majumder, Jeremy M. Boss, Dennis K. Neeld, Alexander P. R. Bally, Yan Tang, Qing Wang
During prolonged exposure to antigens, such as chronic viral infections, sustained T cell receptor (TCR) signaling can result in T cell exhaustion mediated in part by expression of Programmed cell death-1 (PD-1) encoded by the Pdcd1 gene. Here, dynam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421dc4dee29010f479c887dc811430c5
https://doi.org/10.1101/645838
https://doi.org/10.1101/645838