Zobrazeno 1 - 10
of 386
pro vyhledávání: '"R Balfour Sartor"'
Autor:
Ellen Li, Yuanhao Zhang, Xinyu Tian, Xuefeng Wang, Grace Gathungu, Ashley Wolber, Shehzad S Shiekh, R Balfour Sartor, Nicholas O Davidson, Matthew A Ciorba, Wei Zhu, Leah M Nelson, Charles E Robertson, Daniel N Frank
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0213108 (2019)
We have previously identified NOD2 genotype and inflammatory bowel diseases (IBD) phenotype, as associated with shifts in the ileal microbiome ("dysbiosis") in a patient cohort. Here we report an integrative analysis of an expanded number of Crohn's
Externí odkaz:
https://doaj.org/article/ad3762b0d92d4bcf81d74fefb6118511
Autor:
Soeren Ocvirk, Irina G Sava, Isabella Lengfelder, Ilias Lagkouvardos, Natalie Steck, Jung H Roh, Sandrine Tchaptchet, Yinyin Bao, Jonathan J Hansen, Johannes Huebner, Ian M Carroll, Barbara E Murray, R Balfour Sartor, Dirk Haller
Publikováno v:
PLoS Pathogens, Vol 11, Iss 6, p e1004911 (2015)
The commensal Enterococcus faecalis is among the most common causes of nosocomial infections. Recent findings regarding increased abundance of enterococci in the intestinal microbiota of patients with inflammatory bowel diseases and induction of coli
Externí odkaz:
https://doaj.org/article/1f0b806b1a7640249bd748c0d0b99e8c
Autor:
Laura Goeser, Ting-Jia Fan, Sandrine Tchaptchet, Nikolas Stasulli, William E Goldman, R Balfour Sartor, Jonathan J Hansen
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120249 (2015)
Many intracellular bacterial pathogens possess virulence factors that prevent detection and killing by macrophages. However, similar virulence factors in non-pathogenic bacteria are less well-characterized and may contribute to the pathogenesis of ch
Externí odkaz:
https://doaj.org/article/d003947ac2cf428aadeeb139bab5b883
Autor:
Andrew P Morgan, James J Crowley, Randal J Nonneman, Corey R Quackenbush, Cheryl N Miller, Allison K Ryan, Molly A Bogue, Sur Herrera Paredes, Scott Yourstone, Ian M Carroll, Thomas H Kawula, Maureen A Bower, R Balfour Sartor, Patrick F Sullivan
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115225 (2014)
The second-generation antipsychotic olanzapine is effective in reducing psychotic symptoms but can cause extreme weight gain in human patients. We investigated the role of the gut microbiota in this adverse drug effect using a mouse model. First, we
Externí odkaz:
https://doaj.org/article/6b50b2b12320446f8700e0bed06565e1
Autor:
R Balfour Sartor
Publikováno v:
Canadian Journal of Gastroenterology, Vol 9, Iss 3, Pp 147-152 (1995)
The critical importance of host genetic susceptibility in determining chronicity, aggressiveness and complications of intestinal inflammation is clearly demonstrated by studies of inbred rodents, transgenic rats and spontaneous mutants. Inbred Lewis
Externí odkaz:
https://doaj.org/article/d3f74378254d421a9efae98a020fe3d8
Autor:
R Balfour Sartor
Publikováno v:
Canadian Journal of Gastroenterology, Vol 9, Iss 6, Pp 309-315 (1995)
The recent explosion of transgenic and targeted gene deleted (knockout [KO]) rodents has yielded a number of new animal models of spontaneous, chronic intestinal inflammation that have provided novel insights into the pathogenesis of human inflammato
Externí odkaz:
https://doaj.org/article/6b5b14a021c849d6997c4035c1159f7f
Autor:
Jonathan J Hansen, Yong Huang, Daniel A Peterson, Laura Goeser, Ting-Jia Fan, Eugene B Chang, R Balfour Sartor
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42645 (2012)
Inflammatory bowel diseases (IBD) may be caused in part by aberrant immune responses to commensal intestinal microbes including the well-characterized anaerobic gut commensal Bacteroides thetaiotaomicron (B. theta). Healthy, germ-free HLA-B27 transge
Externí odkaz:
https://doaj.org/article/6208a66cd4ca4c94be696925670e5763
Autor:
Ellen Li, Christina M Hamm, Ajay S Gulati, R Balfour Sartor, Hongyan Chen, Xiao Wu, Tianyi Zhang, F James Rohlf, Wei Zhu, Chi Gu, Charles E Robertson, Norman R Pace, Edgar C Boedeker, Noam Harpaz, Jeffrey Yuan, George M Weinstock, Erica Sodergren, Daniel N Frank
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e26284 (2012)
We tested the hypothesis that Crohn's disease (CD)-related genetic polymorphisms involved in host innate immunity are associated with shifts in human ileum-associated microbial composition in a cross-sectional analysis of human ileal samples. Sanger
Externí odkaz:
https://doaj.org/article/c0f222c346084027b069328b2cde39b9
Autor:
Ajay S Gulati, Michael T Shanahan, Janelle C Arthur, Emily Grossniklaus, Richard J von Furstenberg, Lieselotte Kreuk, Susan J Henning, Christian Jobin, R Balfour Sartor
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32403 (2012)
Increasing evidence supports the central role of Paneth cells in maintaining intestinal host-microbial homeostasis. However, the direct impact of host genotype on Paneth cell function remains unclear. Here, we characterize key differences in Paneth c
Externí odkaz:
https://doaj.org/article/f7b812795bde4fb9a4bfa0d87c634e46
Autor:
R Balfour Sartor
Publikováno v:
Canadian Journal of Gastroenterology, Vol 7, Iss 2, Pp 132-138 (1993)
Externí odkaz:
https://doaj.org/article/e62e2fcf34d84e7e86785e0ada0b390e