Zobrazeno 1 - 10 of 11 pro vyhledávání: '"R B Warner"'
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Akademický článek
Impact-induced acceleration by obstacles
Autor: N A Corbin, J A Hanna, W R Royston, H Singh, R B Warner
Publikováno v: New Journal of Physics, Vol 20, Iss 5, p 053031 (2018)
We explore a surprising phenomenon in which an obstruction accelerates, rather than decelerates, a moving flexible object. It has been claimed that the right kind of discrete chain falling onto a table falls faster than a free-falling body. We confir
Externí odkaz: https://doaj.org/article/9638328c49ce48198341e366f135d6b2
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2
Receptor Interactions of Abbott-81988, A Highly Potent, Non-Peptide Angiotensin-II Antagonist Selective for Type-1 Receptors
Autor: P. A. Morse, R B Warner, Biswanath De, K.W. Oheim, Michael E. Brune, J. Y. Lee, Martin Winn, D. J. Kerkman, Arthur A. Hancock, John F. DeBernardis, Steven A. Buckner, T.M. Zydowsky
Publikováno v: Journal of Receptor Research. 14:229-249
Abbott-81988 (A-81988) was selected from a series of related compounds as a highly potent and selective antagonist of angiotensin receptors. In the rabbit aorta, A-81988 exhibited a pA2 of 10.12 (+/- 0.08) vs. angiotensin-II, for type 1 receptors (AT
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4359a7ae695c0436b5be31abef69a86
https://doi.org/10.3109/10799899409066034
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5
Orthostatic hypotension occurs following α2-adrenoceptor blockade in chronic prazosin-pretreated conscious spontaneously hypertensive rats
Autor: J. Y. Lee, R. B. Warner, M. E. Brune, J. F. DeBernardis
Publikováno v: Journal of Autonomic Pharmacology. 12:191-204
1. Studies were performed to evaluate whether chronic prazosin treatment alters the alpha 2-adrenoceptor function for orthostatic control of arterial blood pressure in conscious spontaneously hypertensive rats (SHR). 2. Conscious SHR (male 300-350 g)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db5e6e2832a49d143a198f53dbd0bbe
https://doi.org/10.1111/j.1474-8673.1992.tb00333.x
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6
Cardiovascular activity of A-74283, a 5-hydroxytryptamine 1A agent, in the spontaneously hypertensive rat
Autor: J Y, Lee, A A, Hancock, R B, Warner, M E, Brune, M D, Meyer, J F, DeBernardis
Publikováno v: Pharmacology. 56(1)
A-74283, (+,-)trans-2-(4-(3a,4,4a,6a,7,7a-hexahydro-4,7-etheno-1 H cyclobut [f] isoindol-1,3-dionyl)-butyl)-9-methoxy-2,2,2a,4,5,9b-hexahydr o-1 H-benz[e]isoindol HC1, was studied in receptor binding assays and in the spontaneously hypertensive rat (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::84a297ff11331dc6401f3f5fc1ccb5a8
https://pubmed.ncbi.nlm.nih.gov/9467184
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7
Preclinical pharmacological actions of (+/-)-(1'R*,3R*)-3-phenyl-1- [1',2',3',4'-tetrahydro-5',6'-methylene-dioxy-1'-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200), a potential antidepressant agent that antagonizes alpha-2 adrenergic receptors and inhibits the neuronal uptake of norepinephrine
Autor: A A, Hancock, S A, Buckner, W J, Giardina, M E, Brune, J Y, Lee, P A, Morse, K W, Oheim, D S, Stanisic, R B, Warner, D J, Kerkman
Publikováno v: The Journal of pharmacology and experimental therapeutics. 272(3)
(+/-)-(1'R*,3R*)-3-phenyl-1-[(1',2',3',4'-tetrahydro-5',6'-methylene- dioxy-1'-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200) was evaluated in a number of biological tests to establish its pharmacological profile of activity. ABT-200 an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::932f8470d5790849c750fc87f86d7759
https://pubmed.ncbi.nlm.nih.gov/7891328
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8
Endothelin ETA receptor antagonist reduces myocardial infarction induced by coronary artery occlusion and reperfusion in the rat
Autor: J Y, Lee, R B, Warner, A L, Adler, T J, Opgenorth
Publikováno v: Pharmacology. 49(5)
The effect of the endothelin ETA receptor antagonist FR 139317 on myocardial infarction was studied in the rat. Under anesthesia, rats were subjected to 30 min of left main coronary artery occlusion and 3 h of reperfusion. FR 139317 (15, 35 and 70 mg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f31f8bda7688672942a62f10bbda5665
https://pubmed.ncbi.nlm.nih.gov/7862744
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9
Characterization of antihypertensive activity of ABBOTT-81988, a nonpeptide angiotensin II antagonist in the renal hypertensive rat
Autor: J Y, Lee, S A, Buckner, M E, Brune, R B, Warner, M, Winn, B, De, T M, Zydowsky, T J, Opgenorth, D J, Kerkman, J F, Debernardis
Publikováno v: The Journal of pharmacology and experimental therapeutics. 268(1)
2-(N-Propyl-N[(2'-[1H-tetrazol-5-yl]biphenyl-4yl)methyl]amin o) pyridine-3-carboxylic acid (ABBOTT-81988), a novel nonpeptide angiotensin II (AII) antagonist, was evaluated to characterize its antihypertensive activity in the conscious renal hyperten
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50c51f9d40be46b30248b2e388a07af7
https://pubmed.ncbi.nlm.nih.gov/8301584
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10
Calcium-induced vasocontractions after alpha-2 adrenergic receptor activation in the dog saphenous vein: comparison to calcium-induced contractions after potassium-depolarization
Autor: J. F. DeBernardis, R. B. Warner, J. Y. Lee, M. E. Brune
Publikováno v: General pharmacology. 21(5)
1. Calcium mediated contractile effects were evoked in phenoxybenzamine (10(-7) M)-pretreated dog saphenous vein (DSV) rings under the continuing presence of norepinephrine (3 x 10(-5) M), a condition that selectively activates alpha 2 (alpha 2)-adre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6b3fe91dcc7e6d384854e255332bc2
https://pubmed.ncbi.nlm.nih.gov/1980472
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