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Akademický článek

Electronic damage in S atoms in a native protein crystal induced by an intense X-ray free-electron laser pulse

Publikováno v: Structural Dynamics, Vol 2, Iss 4, Pp 041703-041703-8 (2015)

Current hard X-ray free-electron laser (XFEL) sources can deliver doses to biological macromolecules well exceeding 1 GGy, in timescales of a few tens of femtoseconds. During the pulse, photoionization can reach the point of saturation in which c

Externí odkaz: https://doaj.org/article/98de9c6dd27d4e1dbb6396e48ef9fce7

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In cellulo crystallization of Trypanosoma brucei IMP dehydrogenase enables the identification of genuine co-factors

Publikováno v: Nature Communications 11(1), 620 (2020). doi:10.1038/s41467-020-14484-w
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature communications, vol 11, iss 1

Sleeping sickness is a fatal disease caused by the protozoan parasite Trypanosoma brucei (Tb). Inosine-5’-monophosphate dehydrogenase (IMPDH) has been proposed as a potential drug target, since it maintains the balance between guanylate deoxynucleo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c7c2b56df31ffdb828d9976649cbbb
https://bib-pubdb1.desy.de/record/435344

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X-ray Diffraction from Membrane Protein Nanocrystals

Autor: Mark S. Hunter, Xiaoyu Wang, Uwe Weierstall, D. Starodub, Stefano Marchesini, David A. Shapiro, John C. H. Spence, Daniel P. DePonte, Richard A. Kirian, Petra Fromme, R. B. Doak

Publikováno v: Biophysical journal 100, 198-206 (2011). doi:10.1016/j.bpj.2010.10.049

Membrane proteins constitute >30% of the proteins in an average cell, and yet the number of currently known structures of unique membrane proteins is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc5036ee784df3ed539bc92de918228

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Powder diffraction from a continuous microjet of submicrometer protein crystals

Autor: John C. H. Spence, Stefano Marchesini, Daniel P. DePonte, Gary G. Hembree, R. B. Doak, Petra Fromme, Uwe Weierstall, David A. Shapiro, Henry N. Chapman, Mark S. Hunter, D. Starodub, Kevin Schmidt

Publikováno v: Journal of Synchrotron Radiation. 15:593-599

Atomic-resolution structures from small proteins have recently been determined from high-quality powder diffraction patterns using a combination of stereochemical restraints and Rietveld refinement [Von Dreele (2007), J. Appl. Cryst. 40, 133-143; Mar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9930cb5ab3fb5ffa8c3b22f4fa68d338
https://doi.org/10.1107/s0909049508024151

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Microscopic fused silica capillary nozzles as supersonic molecular beam sources

Autor: Alan M. Cook, M P Grams, J H Turner, R B Doak

Publikováno v: Journal of Physics D: Applied Physics. 39:930-936

Use of fused silica microcapillary tubing for supersonic molecular beam nozzles is reported. Speed ratio measurements were made with nozzles of various diameters and sidewall profiles, demonstrating that these nozzles perform as well as the best conv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47fcd3405d6db5c28352954e1878cc2a
https://doi.org/10.1088/0022-3727/39/5/006

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The assessment of field ionization detectors for molecular beam use

Autor: R B Doak

Publikováno v: Journal of Physics: Condensed Matter. 16:S2863-S2878

An overly simplistic but nonetheless useful model is employed to explore basic attributes of field ionization detection. The base cross-sectional detection area of a field ionization tip is set by a centrifugal barrier: molecules impinging at too hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d5d85e2035bebc953b96f95528e9ade
https://doi.org/10.1088/0953-8984/16/29/002

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Field ionization detection of supersonic molecular beams

Autor: J. P. Toennies, R. B. Doak, Bodil Holst, A. Heinrich, Yasin Ekinci, T. Al-Kassab

Publikováno v: Review of Scientific Instruments. 75:405-414

Seminal field ionization detection of a supersonic helium beam is reported, including intensity measurements on a continuous beam and time-of-flight measurements on a chopped beam. Also unique to these experiments is the care with which the field ion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e9958110b9fe49836a3b99e423c1806
https://doi.org/10.1063/1.1642743

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Corona discharge supersonic free-jet for III–V nitride growth via A 3Σu+ metastable nitrogen molecules

Autor: C. T. Burns, R. B. Doak, D. C. Jordan

Publikováno v: Journal of Applied Physics. 89:883-892

A corona discharge supersonic free-jet is shown to be a nearly pure source of A 3Σu+ metastable molecular nitrogen, an electronically excited and chemically active form of N2 that is ideally suited to nitride semiconductor growth. Optical emission s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad16fdde430b96be5d437cff89c6d192
https://doi.org/10.1063/1.1331646

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MORPHOLOGICAL CONTROL OF GaN BUFFER LAYERS GROWN BY MOLECULAR BEAM EPITAXY ON 6H–SiC(0001)

Autor: CHANGWU HU, DAVID J. SMITH, R. B. DOAK, I. S. T. TSONG

Publikováno v: Surface Review and Letters. :565-570

The growth of GaN buffer layers of thickness 10–25 nm directly on 6H–SiC (0001) substrates was studied using low energy electron microscopy, atomic force microscopy and cross-sectional transmission electron microscopy. The Ga flux was supplied by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fbb1dc1b64fb9de134597e5ef5dcff4
https://doi.org/10.1142/s0218625x00000701

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