Zobrazeno 1 - 10
of 74
pro vyhledávání: '"R B Belshe"'
Autor:
R B Belshe
Publikováno v:
Clinical Pharmacology & Therapeutics. 82:745-749
Influenza vaccine development is reviewed as an example of ongoing translational research, which is moving fundamental advances in biology into useful products. The types of new influenza vaccines span the gamut of modern biology research and include
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a115684821bfabbb9d63a9c592096a2
https://doi.org/10.1038/sj.clpt.6100419
https://doi.org/10.1038/sj.clpt.6100419
Autor:
Raphael Dolin, M L Clements, John R. Mascola, Francine E. McCutchan, Barney S. Graham, M J McElrath, Mary Clare Walker, Michael C. Keefer, Geoffrey J. Gorse, John G. McNeil, Owen S. Weislow, David H. Schwartz, Donald S. Burke, R B Belshe, S M Belay, S W Snyder, Kenneth F. Wagner
Publikováno v:
Journal of Infectious Diseases. 173:340-348
Phase I studies of volunteers not infected with human immunodeficiency virus type 1 (HIV-1) have shown that immunization with envelope subunit vaccine products elicits antibodies that neutralize laboratory-adapted (prototype) HIV-1 strains in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14c941d08575cd9629844bb3d1c50cc2
https://doi.org/10.1093/infdis/173.2.340
https://doi.org/10.1093/infdis/173.2.340
Autor:
Mary Lou Clements, David A. Schwartz, M J McElrath, R B Belshe, B S Graham, Michael C. Keefer, David C. Montefiori, Don Stablein, Lawrence Corey, Dani P. Bolognesi
Publikováno v:
AIDS Research and Human Retroviruses. 10:1713-1723
We examined the safety and immunogenicity of a baculovirus-derived recombinant HIV-1 envelope glycoprotein vaccine candidate, rgp160 (VaxSyn; MicroGeneSys, Meriden, CT), administered at doses of 160 or 640 micrograms to 56 healthy, HIV-1-seronegative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c9eec5990ade9ac5fd0ac21fadbb575
https://doi.org/10.1089/aid.1994.10.1713
https://doi.org/10.1089/aid.1994.10.1713
Publikováno v:
Journal of General Virology. 75:945-948
The anti-influenza virus drug amantadine was shown to reduce the rate of fusion of liposomes with influenza A viruses whose replication is inhibited by this drug. The fusion with amantadine-resistant viruses was unaffected. Experiments with reassorta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d805376c508b8690921c90917d0779
https://doi.org/10.1099/0022-1317-75-4-945
https://doi.org/10.1099/0022-1317-75-4-945
Autor:
R B Belshe, Raphael Dolin, K Midthun, Mary Lou Clements, Geoffrey J. Gorse, Peter F. Wright, Barney S. Graham, Norbert J. Roberts, Michael C. Keefer, Lawrence Corey
Publikováno v:
Journal of Infectious Diseases. 166:244-252
The safety and immunogenicity of a human immunodeficiency virus type 1 (HIV-1) gp160 recombinant vaccinia virus (HIVAC-1e) vaccine was evaluated in vaccinia-naive, healthy adults at low risk for acquiring HIV-1 infection. Volunteers (n = 36) were ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed9c34847dde061ac7b6271e137fca49
https://doi.org/10.1093/infdis/166.2.244
https://doi.org/10.1093/infdis/166.2.244
Autor:
Richard L. Cerruti, R B Belshe, Percy S. Manchand, Iain S. Sim, Elizabeth Keech, Joseph A. Martin, Edward V. Connell, John Herbert Merrett, Hill Christopher Huw
Publikováno v:
Journal of Medicinal Chemistry. 33:1992-1995
The hydroxy metabolites of rimantadine (3-5) were synthesized and compared to amantadine (1) and rimantadine (2) for their ability to inhibit the replication of influenza viruses in vitro. All three metabolites were inhibitory to wild-type influenza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa60daf956cafc6711d9bb99eeadb66
https://doi.org/10.1021/jm00169a029
https://doi.org/10.1021/jm00169a029
Publikováno v:
Antimicrobial Agents and Chemotherapy. 34:25-28
An animal model for antibiotic secretion across gastric mucosa was developed using adult guinea pigs. Antibiotics were given intramuscularly, and levels in serum and gastric mucosa were measured by high-pressure liquid chromatography at 1, 2, 4, 6, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3003eaeb3de8040a7b619a2e103695
https://doi.org/10.1128/aac.34.1.25
https://doi.org/10.1128/aac.34.1.25
Publikováno v:
The Journal of infectious diseases. 184(5)
Induction of human gammadelta T cells was investigated in subjects who were vaccinated with live recombinant canarypox virus expressing human immunodeficiency virus (HIV) proteins or soluble MN rgp120. Both canarypox and rgp120 induced antigen-specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::509b75bbb6b07229c7db08f171c6c6d6
https://pubmed.ncbi.nlm.nih.gov/11474428
https://pubmed.ncbi.nlm.nih.gov/11474428
Publikováno v:
AIDS (London, England). 14(10)
To study memory T cell proliferative responses and cytokine profiles induced in HIV-1 seronegative volunteers immunized with a live recombinant canarypox vector expressing HIV-1 antigens (ALVAC-HIV) and boosted with a recombinant gp120 subunit vaccin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::717389427004f7fffd0580513d2a2963
https://pubmed.ncbi.nlm.nih.gov/10930151
https://pubmed.ncbi.nlm.nih.gov/10930151
Autor:
F D, Goebel, J W, Mannhalter, R B, Belshe, M M, Eibl, P J, Grob, V, de Gruttola, P D, Griffiths, V, Erfle, M, Kunschak, W, Engl
Publikováno v:
AIDS (London, England). 13(12)
The primary objective of this study was to expand the safety and immunogenicity database of recombinant gp160 as a therapeutic vaccine in the treatment of HIV-infection. Preliminary efficacy data was also sought.This trial was a randomized, double-bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31e58a7a83ce38555deb96f448ce7649
https://pubmed.ncbi.nlm.nih.gov/10465068
https://pubmed.ncbi.nlm.nih.gov/10465068