Zobrazeno 1 - 10
of 21
pro vyhledávání: '"R B, Wilber"'
Autor:
R B Wilber, Richard J. Colonno, Richard C. Zink, Anne Cross, Zachary Goodman, Lori Fernandes, Anna S. Lok, Daniel Shouval, Ching-Lung Lai, Ting-Tsung Chang, Deborah DeHertogh, Hugo Cheinquer
Publikováno v:
New England Journal of Medicine. 354:1011-1020
BACKGROUND Entecavir is a potent and selective antiviral agent that has demonstrated efficacy in phase 2 studies in patients with hepatitis B e antigen (HBeAg)–negative chronic hepatitis B. METHODS In this phase 3, double-blind trial, we randomly a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fbcfd5fda4796473992146b79c0c1d1
https://doi.org/10.1056/nejmoa051287
https://doi.org/10.1056/nejmoa051287
Autor:
J. Zhu, Robert G. Gish, Zachary Goodman, Deborah DeHertogh, Kwang Hyub Han, David Apelian, Robert A. de Man, Jose D. Sollano, Anna S. Lok, Richard J. Colonno, Anne Cross, You Chen Chao, Adrián Gadano, Ting-Tsung Chang, R B Wilber
Publikováno v:
New England Journal of Medicine, 354, 1001-1010. Massachussetts Medical Society
Entecavir is a potent and selective guanosine analogue with significant activity against hepatitis B virus (HBV).In this phase 3, double-blind trial, we randomly assigned 715 patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f811bc04f5db0225a16b9743b4c730
https://doi.org/10.1056/NEJMoa051285
https://doi.org/10.1056/NEJMoa051285
Publikováno v:
Drug Information Journal. 35:1363-1371
Efficacy in HIV clinical trials is measured by changes in HIV RNA levels over time as well as the proportion of subjects with HIV RNA levels below an assay’s threshold of reliable quantification at a single time point. Missing data arise naturally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e2d6e53ec9b9f21ebaeb7643a598257
https://doi.org/10.1177/009286150103500432
https://doi.org/10.1177/009286150103500432
Autor:
Helena Brett-Smith, Robert Zahler, Daniel J. Tenney, Lois D. Lehman-McKeeman, Stephanie Danetz, Nicholas A. Meanwell, R B Wilber, Marc Bifano, Bruce Kreter
Publikováno v:
Antiviral Drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0773f375dc899252ca02c7df27012184
https://doi.org/10.1002/9780470929353.ch28
https://doi.org/10.1002/9780470929353.ch28
Publikováno v:
Antimicrobial Agents and Chemotherapy. 37:1180-1183
Penetration of cefprozil into tonsillar and/or adenoidal tissues was investigated for patients undergoing tonsillectomy and/or adenoidectomy. A total of 29 patients ranging in age from 2 to 14 years participated in the study. The tonsils and/or the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88ccce99d5808630c7486a2872d628a
https://doi.org/10.1128/aac.37.5.1180
https://doi.org/10.1128/aac.37.5.1180
Publikováno v:
Antimicrobial Agents and Chemotherapy. 36:962-965
The effect of antacid on the bioavailability of cefprozil was investigated in a two-way crossover study. Eight healthy male subjects received a single 500-mg oral dose of cefprozil with and without coadministration of 30 ml of an antacid suspension c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e2b09e435fc49dfcbc37c4b8c64184
https://doi.org/10.1128/aac.36.5.962
https://doi.org/10.1128/aac.36.5.962
Publikováno v:
The Journal of Clinical Pharmacology. 31:372-376
Cefprozil, a new broad-spectrum oral cephalosporin, is composed of cis and trans isomers in an approximate 90:10 ratio. The pharmacokinetics of a single oral 1000-mg dose of cefprozil were evaluated in 6 healthy subjects and 24 patients with various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f7dd08787610d8eddf216a9bc3a916
https://doi.org/10.1002/j.1552-4604.1991.tb03720.x
https://doi.org/10.1002/j.1552-4604.1991.tb03720.x
Publikováno v:
The Journal of Clinical Pharmacology. 31:362-371
Cefprozil, a new broad-spectrum oral cephalosporin, is composed of cis and trans isomers in an approximate 90:10 ratio. The pharmacokinetics of a single oral 1000-mg dose of cefprozil were evaluated in 6 healthy subjects and 24 patients with various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7dccac3bd278e88cd4a0d872e9ca5f
https://doi.org/10.1002/j.1552-4604.1991.tb03719.x
https://doi.org/10.1002/j.1552-4604.1991.tb03719.x
Autor:
Juan Carlos Lopez-Talavera, Hie-Won Hann, Ulysses Diva, Chao Wei Hsu, Lennox J. Jeffers, R B Wilber, Anne Cross, Morris Sherman, Laurentius A. Lesmana, Kimberly A. Mencarini, Judy Lao-Tan, Cheng Yuan Peng, Man-Fung Yuen, Nancy Leung, Albert D. Min, Jose D. Sollano
Publikováno v:
Hepatology (Baltimore, Md.). 49(1)
This study was undertaken to compare the early antiviral activity and viral kinetic profiles of entecavir (ETV) versus adefovir (ADV) in hepatitis B e antigen positive nucleoside-naive adults with chronic hepatitis B (CHB). Sixty-nine nucleoside-naiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28bc705b742c7b31d11a0295b9410453
https://pubmed.ncbi.nlm.nih.gov/19065670
https://pubmed.ncbi.nlm.nih.gov/19065670
Autor:
R B Wilber, Rashmi H. Barbhaiya, Kenneth A. Pittman, R. Russell Martin, Wen Chyi Shyu, U A Shukla, Carol Gleason
Publikováno v:
Antimicrobial Agents and Chemotherapy. 34:1198-1203
The objectives of this study were to assess the safety and tolerance of cefprozil, to characterize the pharmacokinetics of cefprozil after administration of multiple doses of the drug, and to compare these pharmacokinetic parameters with those obtain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699674011a09d333588eb7316ea8b876
https://doi.org/10.1128/aac.34.6.1198
https://doi.org/10.1128/aac.34.6.1198