Výsledky vyhledávání

Reconstitution of the B Cell Antigen Receptor Signaling Components in COS Cells

Autor: Sandra J. Saouaf, Joseph B. Bolen, R. B. Rowley, Sandeep Mahajan, S. A. Kut, Joseph Fargnoli

Publikováno v: Journal of Biological Chemistry. 270:27072-27078

To elucidate interactions occurring between B cell protein tyrosine kinases and the signaling components of the B cell antigen receptor, we have co-transfected into COS cells individual tyrosine kinases together with chimeric cell surface receptors c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d594a7c11bd9f50d8f1d96e60410c92a
https://doi.org/10.1074/jbc.270.45.27072

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Syk Protein-tyrosine Kinase Is Regulated by Tyrosine-phosphorylated Iga/Ig/3 Immunoreceptor Tyrosine Activation Motif Binding and Autophosphorylation

Autor: Anne L. Burkhardt, Hann-Guang Chao, Joseph B. Bolen, R. B. Rowley, Gary R. Matsueda

Publikováno v: Journal of Biological Chemistry. 270:11590-11594

Syk is a cytoplasmic protein-tyrosine kinase containing two amino-terminal Src homology 2 domains that is activated following ligation of the B cell antigen receptor. Syk activation in B cells correlates with Syk tyrosine phosphorylation as well as w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb937a9bb58f91527931046f8cb3c4c2
https://doi.org/10.1074/jbc.270.19.11590

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Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement

Autor: Joseph Fargnoli, Owen N. Witte, Sandra J. Saouaf, Joseph B. Bolen, R. B. Rowley, S. A. Kut, Anne L. Burkhardt, Satoshi Tsukada, Sandeep Mahajan

Publikováno v: Proceedings of the National Academy of Sciences. 91:9524-9528

We evaluated in WEHI 231 B cells the time-dependent responses of Lyn, Blk, Btk, Syk, and three members of the Jak family of protein tyrosine kinases following antibody-mediated surface engagement of the B-cell antigen receptor. Our results show that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15aa452c89d725b4b6a55ca02385984b
https://doi.org/10.1073/pnas.91.20.9524

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Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement

Autor: Joseph Fargnoli, M. Prendergast, B. Stealey, Anne L. Burkhardt, Sandeep Mahajan, Joseph B. Bolen, R. B. Rowley

Publikováno v: Journal of Biological Chemistry. 269:23642-23647

We evaluated in Jurkat T cells the time-dependent responses of Fyn, Lck, Syk, and Zap following antibody-mediated cross-linking of the T cell antigen receptor. Our results show that the protein kinase activities of Fyn and Lck were activated within s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43003092323a8a3e51daadf8712aee8b
https://doi.org/10.1016/s0021-9258(17)31563-6

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Activation-dependent tyrosine phosphorylation of Fyn-associated proteins in T lymphocytes

Autor: Joseph B. Bolen, R. B. Rowley, Anne L. Burkhardt, Carl Spana, Robert C. Penhallow, Alexander Y. Tsygankov

Publikováno v: Journal of Biological Chemistry. 269:7792-7800

While previous studies have implicated the tyrosine protein kinase p60fyn in antigenic activation of T lymphocytes, it is clear that signal transduction initiated through the antigen receptor requires the concerted actions of several proteins. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76d96a8c90a808b10ea300f5cf5b3857
https://doi.org/10.1016/s0021-9258(17)37356-8

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The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling

Autor: Arthur Weiss, J. B. Bolen, H. Spits, D. H. Chu, J. F. Peyron, R. B. Rowley

Publikováno v: ResearcherID
EMBO journal, 15(22), 6251-6261. Wiley-Blackwell

The protein tyrosine phosphatase CD45 is a critical component of the T cell antigen receptor (TCR) signaling pathway, acting as a positive regulator of Src family protein tyrosine kinases (PTKs) such as Lck. Most CD45-deficient human and murine T cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06d6ac9cde78192a4fef5adcd57bf5f
https://europepmc.org/articles/PMC452448/

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Physical and functional interactions between Lyn and p34cdc2 kinases in irradiated human B-cell precursors

Autor: F M, Uckun, L, Tuel-Ahlgren, K G, Waddick, X, Jun, J, Jin, D E, Myers, R B, Rowley, A L, Burkhardt, J B, Bolen

Publikováno v: The Journal of biological chemistry. 271(11)

Exposure of human B-cell precursors (BCP) to ionizing radiation results in cell cycle arrest at the G2-M checkpoint as a result of inhibitory tyrosine phosphorylation of p34cdc2 . Here, we show that ionizing radiation promotes physical interactions b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::498f4be798152b084340496612c59343
https://pubmed.ncbi.nlm.nih.gov/8626437

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Molecular cloning of rodent p72Syk. Evidence of alternative mRNA splicing

Autor: R B, Rowley, J B, Bolen, J, Fargnoli

Publikováno v: The Journal of biological chemistry. 270(21)

Northern blot analysis of polyadenylated RNA prepared from RBL-2H3 cells revealed the presence of three distinct mRNAs encoding p72Syk, a protein-tyrosine kinase previously shown to be associated with the high affinity IgE receptor present on the sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b078ec811205baa3ff892df101297911
https://pubmed.ncbi.nlm.nih.gov/7759516

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