Zobrazeno 1 - 10
of 601
pro vyhledávání: '"R B, Rothman"'
Publikováno v:
Current Medicinal Chemistry. 4:247-270
Ohmefentanyl., or β-hydroxy-3-methylfentanyl, is an unique member of the 4-anilidopiperidine class of opiates. This review summarizes both the initial studies on mixtures of ohmefentanyl stereoisomers and some more recent studies on the eight indivi
Autor:
Shen, Qingya1,2 (AUTHOR), Tang, Xinyan3 (AUTHOR), Wen, Xin4,5 (AUTHOR), Cheng, Shizhuo1,2,6 (AUTHOR), Xiao, Peng4,5 (AUTHOR), Zang, Shao‐Kun1,2 (AUTHOR), Shen, Dan‐Dan1,2 (AUTHOR), Jiang, Lei3 (AUTHOR), Zheng, Yanrong7 (AUTHOR), Zhang, Huibing1,2 (AUTHOR), Xu, Haomang1,2 (AUTHOR), Mao, Chunyou1,8,9 (AUTHOR), Zhang, Min6 (AUTHOR) min_zhang@zju.edu.cn, Hu, Weiwei3 (AUTHOR) huww@zju.edu.cn, Sun, Jin‐Peng4,5,10 (AUTHOR) sunjinpeng@sdu.edu.cn, Zhang, Yan1,2 (AUTHOR) zhang_yan@zju.edu.cn, Chen, Zhong3,7 (AUTHOR) chenzhong@zju.edu.cn
Publikováno v:
Advanced Science. 6/19/2024, Vol. 11 Issue 23, p1-17. 17p.
Autor:
B R, de Costa, K C, Rice, W D, Bowen, A, Thurkauf, R B, Rothman, L, Band, A E, Jacobson, L, Radesca, P C, Contreras, N M, Gray
Publikováno v:
Journal of Medicinal Chemistry. 33:3100-3110
Certain benzeneacetamides [(-)- and (+)-cis-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl) cyclohexyl]benzeneacetamide] were recently reported to be potent sigma receptor ligands. In order to determine whether efficacy for the sigma receptor could be im
Publikováno v:
The Alkaloids. Chemistry and biology. 56
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 297(2)
Ibogaine is a naturally occurring compound with purported antiaddictive properties. When administered to primates, ibogaine is rapidly o-demethylated to form the metabolite 12-hydroxyibogamine (noribogaine). Peak blood levels of noribogaine exceed th
Publikováno v:
Synapse (New York, N.Y.). 39(1)
A large body of evidence supports the hypothesis that mesolimbic dopamine (DA) mediates, in animal models, the reinforcing effects of central nervous system stimulants such as cocaine and amphetamine. The role DA plays in mediating amphetamine-type s
Autor:
H, Xu, A, Hashimoto, K C, Rice, A E, Jacobson, J B, Thomas, F I, Carroll, J, Lai, R B, Rothman
Publikováno v:
Synapse (New York, N.Y.). 39(1)
Previous data obtained with the cloned rat mu opioid receptor demonstrated that stereochemistry affects the four parameters of the ligand-receptor interaction: potency (ED(50)), efficacy (maximal stimulation), intrinsic efficacy (effect as a function
Publikováno v:
Synapse (New York, N.Y.). 36(2)
Combined administration of the amphetamine analogs phentermine and fenfluramine (PHEN/FEN) has been used in the treatment of obesity. While these medications are thought to modulate monoamine transmission, the precise neurochemical effects of the PHE
Publikováno v:
Synapse (New York, N.Y.). 35(3)
The abuse of methamphetamine (METH) and other amphetamine-like stimulants is a growing problem in the United States. METH is a substrate for the 12-transmembrane proteins which function as transporters for the biogenic amines dopamine (DA), serotonin
Publikováno v:
Synapse (New York, N.Y.). 34(4)
There is strong evidence supporting the existence of multiple kappa receptors. Previous studies proposed that U69,593 and (+)-tifluadom act on different kappa receptor subtypes, kappa(1) (kappa(1)) and kappa(2) (kappa(2)), respectively. In this study