Zobrazeno 1 - 10
of 269
pro vyhledávání: '"R B, Merrifield"'
Autor:
James P. Tam, R. B. Merrifield
Publikováno v:
International Journal of Peptide and Protein Research. 26:262-273
A successful synthesis of human gastrin I in 60% overall yield based on the first residue attached to a benzhydrylamine-resin was achieved by the stepwise solid-phase method. The synthesis was carried out on a 1% crosslinked polystyrene support, usin
Autor:
Hans G. Boman, Josep Ubach, R. B. Merrifield, E. L. Merrifield, David Andreu, Scott A. Mitchell
Publikováno v:
International Journal of Peptide and Protein Research. 46:214-220
The all-D enantiomers of six 15-residue hybrids of cecropin A and melittin were synthesized. They contained the seven N-terminal residues of cecropin A, followed by eight residues from the N-terminal region of melittin. They were pure and of the corr
Publikováno v:
Scopus-Elsevier
A protected tridecapeptide of the sequence Boc-Lys(2CIZ)-Arg(Tos)-Leu-Glu (OcHex)-Trp(For)-Ile-Ala-Ala-Ser(Bzl)-Arg(Tos)-Asn-Lys(2CIZ)-Gly-OH, representing residues 43-55 of the variable region of the heavy chain of mouse myeloma protein M603, was sy
Publikováno v:
International Journal of Peptide and Protein Research. 29:545-557
[Tyr22] glucagon and [desHis1, Tyr22] glucagon were synthesized by an improved solid phase procedure on a Pam-resin. The course of the synthesis was monitored by quantitative ninhydrin analysis and preview sequencing. Following cleavage by the low/hi
Autor:
R. B. Merrifield, Su-Sun Wang
Publikováno v:
International Journal of Peptide and Protein Research. 4:309-318
The t-alkyloxycarbonylhydrazide-resin, H2NNHCOOC(CH3)2CH2CH2-copolystyrene-divinylbenzene, was applied to the solid phase synthesis of a protected decapeptide hydrazide, Z-Ala-Val-Ser(Bzl)-Ile-GIn-Phe-Met(O)-Asn-Leu-NHNH2, and the t-alkyl alcohol-res
Publikováno v:
International Journal of Peptide and Protein Research. 28:536-541
Thymosin beta 9, a 41 residue thymic polypeptide, has been synthesized by a solid phase method. A modification of the low HF method was used to deprotect and cleave the peptide from the resin. Thymosin beta 9 was then obtained in analytically pure fo
Publikováno v:
Scopus-Elsevier
The deprotection of S-4-methylbenzyl-cysteine in HF was studied as a function of acidity and scavengers employed and a highly effective procedure was developed. Under conditions of low acidity which promote SN2 deprotection of benzyl alcohol-derived
Publikováno v:
International Journal of Peptide and Protein Research. 6:103-109
A nonapeptide, Arg-Glu-Leu-Glu-Asp-Gly-Thr-Pro-Arg, corresponding to the 123–131 sequence of bovine pituitary growth hormone, was prepared by a modified solid phase synthesis. To avoid an acid- or base-catalysed rearrangement at the Asp-Gly bond, w
Publikováno v:
Scopus-Elsevier
4-Dimethylaminopyridine (DMAP) was found to be useful in the enhancement of peptide coupling reactions mediated by dicyclohexylcarbodiimide or symmetrical anhydrides. In an automated synthesis of the model heptapeptide Boc-Ala-Cle-Ile-Val-Pro-Arg(Tos
Synthesis and antibacterial action of cecropin and proline-arginine-rich peptides from pig intestine
Publikováno v:
The Journal of Peptide Research. 49:59-66
Two antimicrobial peptides, cecropin P1 (CP1), with a C-terminal carboxyl group, and PR-39, with an amidated, C-terminus, are found in the small intestine of the pig. Each is active against both Gram-positive and Gram-negative bacteria. We have synth