Zobrazeno 1 - 10
of 44
pro vyhledávání: '"R B, Mccall"'
Publikováno v:
Journal of Veterinary Pharmacology and Therapeutics. 31:220-229
The present study characterizes the safety, pharmacokinetics, and anti-emetic effects of the selective NK-1 receptor antagonist maropitant in the cat. Safety of maropitant was determined following 15 days of subcutaneous (SC) administration at 0.5-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9dfc6e05ad33fa897d362e9e5a5f3c
https://doi.org/10.1111/j.1365-2885.2008.00952.x
https://doi.org/10.1111/j.1365-2885.2008.00952.x
Autor:
C H, Lin, S R, Haadsma-Svensson, R A, Lahti, R B, McCall, M F, Piercey, P J, Schreur, P F, Von Voigtlander, M W, Smith, C G, Chidester
Publikováno v:
Journal of Medicinal Chemistry. 36:1053-1068
The synthesis and structure-activity relationships (SAR) of 2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole derivatives (3) are described. These compounds are conformationally restricted, angular tricyclic analogs of 2-aminotetralin. The synthesis was achie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915eed22f4246a6b69375ea3c44c52a9
https://doi.org/10.1021/jm00060a014
https://doi.org/10.1021/jm00060a014
Autor:
R Huff, R TenBrink, Robert L Hoffman, N R Higdon, N B Ghazal, C L Bergh, R B McCall, Michael D. Ennis, C L Chio, E Hall, K Meisheri
Publikováno v:
Cephalalgia : an international journal of headache. 22(10)
The present study describes the preclinical pharmacology of a highly selective 5-HT1Dreceptor agonist PNU-142633. PNU-142633 binds with a Ki of 6 nM at the human 5-HT1Dreceptor and a Ki of > 18 000 nM at the human 5-HT1B receptor. The intrinsic activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b671ef13fee7f8a28a64c549725f0bfd
https://pubmed.ncbi.nlm.nih.gov/12485205
https://pubmed.ncbi.nlm.nih.gov/12485205
Autor:
K M, Merchant, G S, Gill, D W, Harris, R M, Huff, M J, Eaton, K, Lookingland, B S, Lutzke, R B, Mccall, M F, Piercey, P J, Schreur, V H, Sethy, M W, Smith, K A, Svensson, A H, Tang, P F, Vonvoigtlander, R E, Tenbrink
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 279(3)
Dopamine D2-like receptors play an important role in the pharmacotherapy of psychotic disorders. Molecular and cellular techniques have identified distinct gene products (D2-long, D2-short, D3 and D4) displaying the D2 receptor pharmacology. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::259d6fa65fe3dc2859628be188e3cc22
https://pubmed.ncbi.nlm.nih.gov/8968364
https://pubmed.ncbi.nlm.nih.gov/8968364
Autor:
R B, McCall
Publikováno v:
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::def0fc75a0e3e6b4054bafba12f6f517
https://pubmed.ncbi.nlm.nih.gov/8754203
https://pubmed.ncbi.nlm.nih.gov/8754203
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 271(2)
The purpose of this study was to characterize the bradycardic effects of 5-hydroxytryptamine (5-HT)1A receptor agonists in the chloralose-anesthetized spinal cat and to determine if tolerance develops to the bradycardia produced by these drugs. 5-HT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2dd9b709dc4469077af1ed867f886aa8
https://pubmed.ncbi.nlm.nih.gov/7965796
https://pubmed.ncbi.nlm.nih.gov/7965796
Autor:
R B, McCall, A G, Romero, M J, Bienkowski, D W, Harris, J C, McGuire, M F, Piercey, M E, Shuck, M W, Smith, K A, Svensson, P J, Schreur
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 271(2)
The purpose of the present study was to characterize U-92016A [(+)-R)-2-cyano-N,N-dipropyl-8-amino-6,7,8,9-tetrahydro-3H-benz[e] indole] as a 5-hydroxytryptamine (5-HT)1A receptor agonist and to compare its activity with that of standard 5-HT1A recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce0e1872980bb499ace2f04a9d431c0d
https://pubmed.ncbi.nlm.nih.gov/7965808
https://pubmed.ncbi.nlm.nih.gov/7965808
Autor:
R B, McCall, M E, Clement
Publikováno v:
Pharmacological reviews. 46(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bce72a0b3708a8d1d473322f30660233
https://pubmed.ncbi.nlm.nih.gov/7831380
https://pubmed.ncbi.nlm.nih.gov/7831380
Autor:
M F, Piercey, A H, Tang, R A, Lahti, P F, VonVoigtlander, P J, Schreur, R B, McCall, J T, Lum-Ragan, W E, Hoffmann, S R, Franklin, R A, Code
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 268(3)
U-67413B (4-hydroxydipropylaminodihydrophenalene) bound with high affinity to both 5-hydroxytryptamine (HT)1A and D2-dopamine (DA) receptor sites. U-67413B depressed 5-HT and DA cell firing rates and depressed synthesis of both neurotransmitters. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f2db64e33d1b463083a75390ed65e81
https://pubmed.ncbi.nlm.nih.gov/7908053
https://pubmed.ncbi.nlm.nih.gov/7908053
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 268(1)
The effects of the putative serotonin (5-HT)1A receptor antagonists WAY-100135 (WAY) and spiperone on the neuronal activity recorded from medullary and dorsal raphe 5-HT neurons and the inferior cardiac sympathetic nerve were investigated in chloralo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bb6a2fc6791c838c53c7c0aeb7e8b238
https://pubmed.ncbi.nlm.nih.gov/8301586
https://pubmed.ncbi.nlm.nih.gov/8301586