Zobrazeno 1 - 10 of 11 pro vyhledávání: '"R B, Lock"'
1
Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival
Autor: R B, Lock, L, Stribinskiene
Publikováno v: Cancer research. 56(17)
The Bcl-2 oncoprotein, which is expressed in a variety of human malignancies, blocks apoptosis induced by chemotherapeutic drugs, including the topoisomerase II inhibitor, etoposide. To determine the significance of Bcl-2 in etoposide-induced death o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5df167318954ab88374ba625ff662c8
https://pubmed.ncbi.nlm.nih.gov/8752171
Zobrazit plný text záznamu
2
Concentration-dependent differences in the mechanisms by which caffeine potentiates etoposide cytotoxicity in HeLa cells
Autor: R B, Lock, O V, Galperina, R C, Feldhoff, L J, Rhodes
Publikováno v: Cancer research. 54(18)
Morphological examination of HeLa cells exposed to etoposide for 1 h revealed two distinct modes of death: (a) within 6 h of drug removal, shrunken cells appeared which contained vacuolated cytoplasm and regions of intense chromatin staining, consist
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b816eebf781b5cb69b97caa0e17f694
https://pubmed.ncbi.nlm.nih.gov/8069859
Zobrazit plný text záznamu
3
Inhibition of p34cdc2 kinase activation, p34cdc2 tyrosine dephosphorylation, and mitotic progression in Chinese hamster ovary cells exposed to etoposide
Autor: R B, Lock
Publikováno v: Cancer research. 52(7)
p34cdc2 kinase, an enzyme essential for mitosis in mammalian cells, may play a role in etoposide-induced G2 phase arrest of Chinese hamster ovary cells. In this study, etoposide is shown to cause inhibition of a specific p34cdc2 kinase activation pat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0d253e0f2de558133e4c0e164e045fd1
https://pubmed.ncbi.nlm.nih.gov/1551112
Zobrazit plný text záznamu
4
Attenuated topoisomerase II content directly correlates with a low level of drug resistance in a Chinese hamster ovary cell line
Autor: C D, Webb, M D, Latham, R B, Lock, D M, Sullivan
Publikováno v: Cancer research. 51(24)
A new multiple drug-resistant Chinese hamster ovary cell line, CHO-SMR5, has been isolated which demonstrates a direct correlation between reduced cellular topoisomerase II activity (5-fold reduction) and a low level of resistance (3- to 7-fold) to t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ee29c5415b55cc7ecf6b527ec6a6c7c
https://pubmed.ncbi.nlm.nih.gov/1660341
Zobrazit plný text záznamu
5
Possible role for p34cdc2 kinase in etoposide-induced cell death of Chinese hamster ovary cells
Autor: R B, Lock, W E, Ross
Publikováno v: Cancer research. 50(12)
In an effort to shed light upon the processes of antitumor drug-induced cell death, we have carried out a systemic study of the effects of the anti-topoisomerase II agent, etoposide, on Chinese hamster ovary cells. Treatment of Chinese hamster ovary
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ea877803f9e82326167fb397df3933c
https://pubmed.ncbi.nlm.nih.gov/2187602
Zobrazit plný text záznamu
6
Inhibition of p34cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells
Autor: R B, Lock, W E, Ross
Publikováno v: Cancer research. 50(12)
The mammalian homologue of the yeast cdc2 gene product, p34cdc2, is a cell cycle-regulated protein essential for mitosis. We have used polyclonal antisera raised against a peptide corresponding to the carboxyl terminus of the sequence of human cdc2 t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bdc65636af9cac0d2e9c0ed6e54651ad
https://pubmed.ncbi.nlm.nih.gov/2187601
Zobrazit plný text záznamu
8
Depletion of Topoisomerase II in Isolated Nuclei during a Glucose-Regulated Stress Response
Autor: J W, Shen, J R, Subjeck, R B, Lock, W E, Ross
Publikováno v: Molecular and Cellular Biology. 9:3284-3291
Conditions, such as anoxia or glucose starvation, which induce the glucose-regulated set of stress proteins also lead to resistance to adriamycin (J. Shen, C. Hughes, C. Chao, J. Cai, C. Bartels, T. Gessner, and J. Subjeck, Proc. Natl. Acad. Sci. USA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e711b59121b6ac3e802b822ca0ac0fd
https://doi.org/10.1128/mcb.9.8.3284-3291.1989
Zobrazit plný text záznamu
9
Interactions between antitumor drugs and radiation in mammalian tumor cell lines: differential drug responses and mechanisms of resistance following fractionated X-irradiation or continuous drug exposure in vitro
Autor: B T, Hill, R D, Whelan, L K, Hosking, S A, Shellard, P, Bedford, R B, Lock
Publikováno v: NCI monographs : a publication of the National Cancer Institute. (6)
Drug-resistant mammalian tumor cell lines have been derived by either fractionated x-irradiation treatment or exposure to vincristine or etoposide (VP-16-213) in vitro. Analyses of the patterns of responses expressed by these differently derived, res
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::78c0717d72198f41434ece54f9d14ded
https://pubmed.ncbi.nlm.nih.gov/3352761
Zobrazit plný text záznamu
10
DNA topoisomerases in cancer therapy
Autor: R B, Lock, W E, Ross
Publikováno v: Anti-cancer drug design. 2(2)
DNA topoisomerases I and II are nuclear enzymes which modify DNA topology by their ability to break and reseal one or both strands in concert. Each of these enzymes has important functions in DNA replication, and very likely in other genetic processe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e663506e214c1d9c11c268ee7aac3776
https://pubmed.ncbi.nlm.nih.gov/2835059
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje