Zobrazeno 1 - 10
of 13
pro vyhledávání: '"R B, Gaynor"'
Publikováno v:
Nuclear Factor кB ISBN: 9789401039833
The NF-κB-signaling pathway has attracted widespread interest due to its fundamental role in the regulation of immune and inflammatory responses and in the control of cellular proliferation. A number of steps in the NF-κB pathway are potential targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f98d7baa75e4f41cc1c27da7781b99df
https://doi.org/10.1007/978-94-010-0163-2_9
https://doi.org/10.1007/978-94-010-0163-2_9
Publikováno v:
The Journal of biological chemistry. 276(45)
Both the beta-catenin and the nuclear factor kappaB (NF-kappaB) proteins are important regulators of gene expression and cellular proliferation. Two kinases, IKKalpha and IKKbeta, are critical activators of the NF-kappaB pathway. Here we present evid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29529e0813502a45c51d3bec68879b02
https://pubmed.ncbi.nlm.nih.gov/11527961
https://pubmed.ncbi.nlm.nih.gov/11527961
Publikováno v:
The Journal of biological chemistry. 276(39)
IKKgamma/NEMO is an essential regulatory component of the IkappaB kinase complex that is required for NF-kappaB activation in response to various stimuli including tumor necrosis factor-alpha and interleukin-1beta. To investigate the mechanism by whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f156d0c30b58a8193b7276af7bab9c00
https://pubmed.ncbi.nlm.nih.gov/11470788
https://pubmed.ncbi.nlm.nih.gov/11470788
Publikováno v:
The Journal of biological chemistry. 276(6)
IKKgamma/NEMO is a protein that is critical for the assembly of the high molecular weight IkappaB kinase (IKK) complex. To investigate the role of IKKgamma/NEMO in the assembly of the IKK complex, we conducted a series of experiments in which the chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9245fae7190323d05868f3b4c6837de2
https://pubmed.ncbi.nlm.nih.gov/11080499
https://pubmed.ncbi.nlm.nih.gov/11080499
Publikováno v:
Molecular and cellular biology. 20(10)
Two related kinases, IkappaB kinase alpha (IKKalpha) and IKKbeta, phosphorylate the IkappaB proteins, leading to their degradation and the subsequent activation of gene expression by NF-kappaB. IKKbeta has a much higher level of kinase activity for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1751bc4c89005ef2416cbe081437166e
https://pubmed.ncbi.nlm.nih.gov/10779355
https://pubmed.ncbi.nlm.nih.gov/10779355
Autor:
X H, Li, R B, Gaynor
Publikováno v:
Gene expression. 7(4-6)
The Tax protein encoded by the human T-cell leukemia virus type 1 (HTLV-1) activates viral gene expression via the ATF/CREB pathway. Tax also induces a variety of cellular genes through activation of the transcription factor NF-kappaB. The ability of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63822f34b89de4f348a72ebc7506fbdc
https://pubmed.ncbi.nlm.nih.gov/10440224
https://pubmed.ncbi.nlm.nih.gov/10440224
Publikováno v:
Molecular and cellular biology. 18(7)
Regulation of the IkappaB alpha and IkappaB beta proteins is critical for modulating NF-kappaB-directed gene expression. Both IkappaB alpha and IkappaB beta are substrates for cellular kinases that phosphorylate the amino and carboxy termini of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::add99191dad9ad62cc90675a6e3b7298
https://pubmed.ncbi.nlm.nih.gov/9632806
https://pubmed.ncbi.nlm.nih.gov/9632806
Publikováno v:
The Journal of biological chemistry. 272(28)
Nuclease hypersensitive sites exist in vivo in the chromatin of the integrated human immunodeficiency virus (HIV)-1 proviral genome, in the 5'-long terminal repeat (LTR) within the promoter/enhancer region near Sp1 and NFkappaB binding sites. Previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5a686f93a3d01d27fbe274c09de6b154
https://pubmed.ncbi.nlm.nih.gov/9211915
https://pubmed.ncbi.nlm.nih.gov/9211915
Autor:
W J, Levin, M F, Press, R B, Gaynor, V P, Sukhatme, T C, Boone, P T, Reissmann, R A, Figlin, E C, Holmes, L M, Souza, D J, Slamon
Publikováno v:
Oncogene. 11(7)
In 1995, there will be 172,000 new cases of lung cancer diagnosed and 153,000 deaths from this disease in the United States. While the pathogenesis of the disease process is poorly understood, a growing body of evidence suggests that abnormalities in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::683588ff9d2940d2dd74d7ea0dccf8f8
https://pubmed.ncbi.nlm.nih.gov/7478546
https://pubmed.ncbi.nlm.nih.gov/7478546
Autor:
M.-A. Pedraza, Jean Marc Jacque, Ronald T. Hay, Lola Folgueira, Françoise Bachelerie, A. R. Noriega, R B Gaynor, José Alcamí, D Harrich, T Laín de Lera
Publikováno v:
The EMBO journal. 14(7)
The role of NF-kappa B-dependent signals in activating the transcriptional activity of the HIV regulatory region (LTR) was analyzed by systematic comparison of HIV LTR activity in human CD4 T cells purified from peripheral blood and a transformed lym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b22ef596f1cc8ba8c9572124353181
https://pubmed.ncbi.nlm.nih.gov/7729429
https://pubmed.ncbi.nlm.nih.gov/7729429