Výsledky vyhledávání

Disposition of bethanidine, N-benzyl-N',N'-dimethylguanidine, in the rat, dog and man

Autor: L B, Turnbull, L, Teng, J, Newman, A N, Chremos, R B, Bruce

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 4(3)

Bethanidine is metabolized in the rat and dog to a significant degree to N-benzyl-N'-methylguanidine, N-benzylguanidine, N-hydroxybenzyl-N'-methylguanidine, N-methylguanidine, N-hydroxybenzyl-N',N''-di-methylguanidine, and benzoic acid, whereas in ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::575425a3f433138553be468c9d1ecba7
https://pubmed.ncbi.nlm.nih.gov/6232

Zobrazit plný text záznamu

Identification of doxapram metabolites using high pressure ion exchange chromatography and mass spectroscopy

Autor: J. E. Pitts, J. B. Forehand, R. B. Bruce

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 3(2)

1. High pressure ion exchange chromatography has been used for separation of metabolites of doxapram from whole dog urine. Thin layer chromatography was used for additional separation and clean-up.2. The structures of the metabolites thus isolated we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d024c9a629ed8492f35823ee99b6f7e3
https://pubmed.ncbi.nlm.nih.gov/4716642

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání