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Chronic Toxicity and Oncogenicity Inhalation Study with Vinyl Acetate in the Rat and Mouse

Autor: R. W. Rickard, H. C.Dreef Van Der Meulen, T. C. Cascieri, T. R. Tyler, Matthew S. Bogdanffy, R. B. Beems, M. B. Vinegar, V.J. Feron

Publikováno v: Fundamental and Applied Toxicology, 2, 23, 215-229

Vinyl acetate was evaluated for chronic toxicity and oncogenicity in male and female rats and mice in a 104-week study. Target concentrations were 0, 50, 200, and 600 ppm. The study included interim terminations at approximately 53 and 83 weeks and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4c297e59b2e17f43570c042bc2e9c5
https://doi.org/10.1006/faat.1994.1100

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Long-term effect of fish oil diet on basal and stimulated plasma glucose and insulin levels in ob/ob mice

Autor: P A, Steerenberg, P K, Beekhof, E J M, Feskens, C J M, Lips, J W M, Höppener, R B, Beems

Publikováno v: Diabetes, nutritionmetabolism. 15(4)

In this study, the ob/ob mouse model was used to investigate epidemiological evidence linking fish intake to relative reduction in incidence of Type 2 diabetes mellitus and glucose. We have investigated, in comparison to low and high fat diets, the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c4da0c09111a03b062ee9df9187e8564
https://pubmed.ncbi.nlm.nih.gov/12416657

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Xpa and Xpa/p53+/- knockout mice: overview of available data

Autor: C F, van Kreijl, P A, McAnulty, R B, Beems, A, Vynckier, H, van Steeg, R, Fransson-Steen, C L, Alden, R, Forster, J W, van der Laan, J, Vandenberghe

Publikováno v: Toxicologic pathology.

DNA repair deficient Xpa-/- and Xpa-/-/p53+/- knock-out mice in a C57BL/6 genetic background, referred to as respectively the XPA and XPA/p53 model, were investigated in the international collaborative research program coordinated by International Li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f3f7ca1283c915a5ef3ac23efefd32e
https://pubmed.ncbi.nlm.nih.gov/11695547

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The relationship between benzo[a]pyrene-induced mutagenesis and carcinogenesis in repair-deficient Cockayne syndrome group B mice

Autor: S W, Wijnhoven, H J, Kool, C T, van Oostrom, R B, Beems, L H, Mullenders, A A, van Zeeland, G T, van der Horst, H, Vrieling, H, van Steeg

Publikováno v: Cancer research. 60(20)

Cockayne syndrome (CS) patients are deficient in the transcription coupled repair (TCR) subpathway of nucleotide excision repair (NER) but in contrast to xeroderma pigmentosum patients, who have a defect in the global genome repair subpathway of NER,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::760dc98f5592366eb5f3a96f6dd75683
https://pubmed.ncbi.nlm.nih.gov/11059760

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Effect of heterozygous loss of p53 on benzo[a]pyrene-induced mutations and tumors in DNA repair-deficient XPA mice

Autor: C T, van Oostrom, M, Boeve, J, van Den Berg, A, de Vries, M E, Dollé, R B, Beems, C F, van Kreijl, J, Vijg, H, van Steeg

Publikováno v: Environmental and molecular mutagenesis. 34(2-3)

XPA-deficient mice have a complete deficiency in nucleotide excision repair, and as such they display a cancer predisposition after exposure to several carcinogens. Besides being sensitive to genotoxic agents applied to the skin, they are also suscep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::663986e83beaf9d035918d7b1b552487
https://pubmed.ncbi.nlm.nih.gov/10529736

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Mouse model for the DNA repair/basal transcription disorder trichothiodystrophy reveals cancer predisposition

Autor: J, de Boer, H, van Steeg, R J, Berg, J, Garssen, J, de Wit, C T, van Oostrum, R B, Beems, G T, van der Horst, C F, van Kreijl, F R, de Gruijl, D, Bootsma, J H, Hoeijmakers, G, Weeda

Publikováno v: Cancer research. 59(14)

Patients with the nucleotide excision repair (NER) disorder xeroderma pigmentosum (XP) are highly predisposed to develop sunlight-induced skin cancer, in remarkable contrast to photosensitive NER-deficient trichothiodystrophy (TTD) patients carrying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::23505fb256a094f0682be13c27176cbd
https://pubmed.ncbi.nlm.nih.gov/10416615

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Spontaneous liver tumors and benzo[a]pyrene-induced lymphomas in XPA-deficient mice

Autor: A, de Vries, C T, van Oostrom, P M, Dortant, R B, Beems, C F, van Kreijl, P J, Capel, H, van Steeg

Publikováno v: Molecular carcinogenesis. 19(1)

Defects in the xeroderma pigmentosum complementation group A-correcting (XPA) gene, which encodes a component of the nucleotide excision repair (NER) pathway, are associated with the cancer-prone human disease xeroderma pigmentosum. We previously gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a7cd467b0a3f527222a114f93e27b240
https://pubmed.ncbi.nlm.nih.gov/9180928

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Co-variance of chemically and histologically analysed severity of dystrophic cardiac calcification in mice

Autor: F. A. R. van den Broek, A. C. Beynen, A. X. M. Fielmich-Bouwman, R. B. Beems, A. G. Lemmens, G. van Tintelen

Publikováno v: Laboratory animals. 31(1)

Dystrophic cardiac calcification (DCC) is a post-mortem finding in mice of various strains frequently used in biomedical research. The major aim of this study was to see whether DCC severity can be assessed by chemical analysis of calcium in the hear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9940df8f5699aba716ce35cd44bf030
https://pubmed.ncbi.nlm.nih.gov/9121111

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Comparison of the antiatherogenic effects of isradipine and ramipril in cholesterol-fed rabbits: II. Effect on regression of atherosclerosis and restoration of endothelial function

Autor: J, Riezebos, W, Vleeming, R B, Beems, J G, van Amsterdam, G W, Meijer, D J, de Wildt, A J, Porsius, J, Wemer

Publikováno v: Journal of cardiovascular pharmacology. 23(3)

We report the effects of isradipine and ramipril on regression of diet-induced atherosclerosis in rabbits. Regression of diet-induced atherosclerosis was not significantly affected by ramipril, but isradipine significantly retarded regression. Thirty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5698d3896c26719cc6195e7fe0f06d60
https://pubmed.ncbi.nlm.nih.gov/7515986

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Comparison of the antiatherogenic effects of isradipine and ramipril in cholesterol-fed rabbits: I. Effect on progression of atherosclerosis and endothelial dysfunction

Autor: J, Riezebos, W, Vleeming, R B, Beems, J G, van Amsterdam, G W, Meijer, D J, de Wildt, A J, Porsius, J, Wemer

Publikováno v: Journal of cardiovascular pharmacology. 23(3)

This study was designed to compare the effects of a calcium antagonist (isradipine) and a converting enzyme inhibitor (ramipril) on progression and regression of atherosclerosis in hypercholesterolemic rabbits. Sixty rabbits in three groups were fed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8bfb84b25e54bb0da59fb828f1b9b1e7
https://pubmed.ncbi.nlm.nih.gov/7515985

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