Zobrazeno 1 - 10
of 65
pro vyhledávání: '"R Anthony Crowther"'
Autor:
Wenjuan Zhang, Benjamin Falcon, Alexey G Murzin, Juan Fan, R Anthony Crowther, Michel Goedert, Sjors HW Scheres
Publikováno v:
eLife, Vol 8 (2019)
Assembly of microtubule-associated protein tau into filamentous inclusions underlies a range of neurodegenerative diseases. Tau filaments adopt different conformations in Alzheimer’s and Pick’s diseases. Here, we used cryo- and immuno- electron m
Externí odkaz:
https://doaj.org/article/ee4f6398c129456c86cb564b7b6c494a
Autor:
Manuel Schweighauser, Alexey G. Murzin, Jennifer Macdonald, Isabelle Lavenir, R. Anthony Crowther, Sjors H.W. Scheres, Michel Goedert
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-11 (2023)
Abstract Mice transgenic for human mutant P301S tau are widely used as models for human tauopathies. They develop neurodegeneration and abundant filamentous inclusions made of human mutant four-repeat tau. Here we used electron cryo-microscopy (cryo-
Externí odkaz:
https://doaj.org/article/43edd87f5ecc46a6b3d9100ebbe7d73f
Autor:
R. Anthony Crowther
Publikováno v:
Biochemical Society Transactions
Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, pose an increasingly severe burden for individuals and society in an ageing population. The causes and mechanisms of the diseases are poorly understood and as yet there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::397017c4e0c4bb3bf5d81ccaba78c23e
https://pubmed.ncbi.nlm.nih.gov/34812894
https://pubmed.ncbi.nlm.nih.gov/34812894
Autor:
Michel Goedert, Benjamin Falcon, Alexey G. Murzin, Kathy L. Newell, Wenjuan Zhang, R. Anthony Crowther, Ruben Vidal, Jasenko Zivanov, Sjors H.W. Scheres, Bernardino Ghetti, Holly J. Garringer
Publikováno v:
Nature
Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy that is associated with repetitive head impacts or exposure to blast waves. First described as punch-drunk syndrome and dementia pugilistica in retired boxers1–3, CTE has since
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b178d0cdaa0c7366cc3f60620795fd
https://pubmed.ncbi.nlm.nih.gov/30988502
https://pubmed.ncbi.nlm.nih.gov/30988502
Publikováno v:
Annual review of neuroscience. 40
A pathway from the natively unfolded microtubule-associated protein Tau to a highly structured amyloid fibril underlies human Tauopathies. This ordered assembly causes disease and represents the gain of toxic function. In recent years, evidence has a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da087761169370d88c120653e0ddc267
https://pubmed.ncbi.nlm.nih.gov/28772101
https://pubmed.ncbi.nlm.nih.gov/28772101
Autor:
Garib N. Murshudov, Anthony W. P. Fitzpatrick, Michel Goedert, Benjamin Falcon, Bernardino Ghetti, Shaoda He, Alexey G. Murzin, Sjors H.W. Scheres, Holly J. Garringer, R. Anthony Crowther
Publikováno v:
Nature
Alzheimer’s disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in the cerebral cortex. Neurofibrillary le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829961e7a2e29c0b5d205d79c6dd9422
https://pubmed.ncbi.nlm.nih.gov/28731038
https://pubmed.ncbi.nlm.nih.gov/28731038
Autor:
Nicola Berg, R. Anthony Crowther, Laura Gasparini, Michel Goedert, Maria Grazia Spillantini, Keith R Martin, Michael P. Coleman
Publikováno v:
Neurobiology of Aging. 32:419-433
Tau inclusions play a key role in the pathogenesis of tauopathies. Altered tau levels have been detected in retina and optic nerve of patients with glaucoma, suggesting the possibility of shared pathogenic mechanisms with tauopathies. Here we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3195e916cf208ea73fdbfa72e43b5d2
https://doi.org/10.1016/j.neurobiolaging.2009.03.002
https://doi.org/10.1016/j.neurobiolaging.2009.03.002
Autor:
Louise C. Serpell, Michel Goedert, Ross Jakes, Graham Fraser, David J. Owen, Shahin Zibaee, R. Anthony Crowther
Publikováno v:
Journal of Biological Chemistry. 285:38555-38567
Filamentous inclusions made of α-synuclein are found in nerve cells and glial cells in a number of human neurodegenerative diseases, including Parkinson disease, dementia with Lewy bodies, and multiple system atrophy. The assembly and spreading of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb51b5304feb512995f8c6dbbec1f3d
https://doi.org/10.1074/jbc.m110.160721
https://doi.org/10.1074/jbc.m110.160721
Publikováno v:
Hepatology. 52:1600-1610
Genotype D occult hepatitis B virus (HBV) infections (OBIs) have a high frequency of amino acid substitutions in the major hydrophilic region of the small surface protein (S protein). This possibly reflects an escape mutation mechanism to evade detec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0292b7b90fca0425f8c7fcb618c30b
https://doi.org/10.1002/hep.23886
https://doi.org/10.1002/hep.23886