Zobrazeno 1 - 10
of 10
pro vyhledávání: '"R Alan Chrusciel"'
Autor:
Cynthia M. Megyola, Tim O'Connell, Ronald R. Breaker, Catherine A. Stewart, R. Alan Chrusciel, Toni J. Poel, Heinrich J. Schostarez, Cheryl Quinn, Mark Plummer, Paul Aristoff, David Osterman, Daniel P. Walker, Peter G. M. Wuts, Kenneth F. Blount
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:5736-5746
Novel mechanisms of action and new chemical scaffolds are needed to rejuvenate antibacterial drug discovery, and riboswitch regulators of bacterial gene expression are a promising class of targets for the discovery of new leads. Herein, we report the
Autor:
R Alan Chrusciel, Karen R Romines
Publikováno v:
Expert Opinion on Therapeutic Patents. 7:111-121
Over the past two years, HIV protease inhibitors have generated considerable excitement, both among the AIDS research community and among HIV-positive patients, when the first three drugs in this class (Hoffmann-La Roche's saquinavir, Abbott's ritona
Autor:
E. Ann Hallinan, David B. Reitz, Timothy J. Hagen, Sofya Tsymbalov, James J. Li, R. Alan Chrusciel, Monica B. Norton
Publikováno v:
Journal of Heterocyclic Chemistry. 31:1689-1696
Lithiation of 8-chlorodibenz[b,f][1,4]oxazepine-10-tert-butylcarbamate (1) is described. Electrophilic substitution of the resulting N-Boc dibenzoxazepine α- lithioamine 2 with ketones, aldehydes, nitriles, iso-cyanates and imines, followed by an in
Autor:
Michael G. Kahn, Vivien Yee, R. Alan Chrusciel, Hiroshi Nakanishi, A. Tulinksy, Richard Shen, Tswei Ping Wu, Cheryl Priebe
Publikováno v:
"Protein Engineering, Design and Selection". 6:471-478
Thrombin displays remarkable specificity, effecting the removal of fibrinopeptides A and B of fibrinogen through the selective cleavage of two Arg-Gly bonds between the 181 Arg/Lys-Xaa bonds in fibrinogen. Significant advances have been made in recen
Autor:
R. Alan Chrusciel, Hiroshi Nakanishi, Michito Sato, Jessie Y.-H. Lee, Michael Kahn, Michael E. Johnson
Publikováno v:
Biochemical and Biophysical Research Communications. 187:999-1006
Gamma-turns are regular secondary structure elements, found with some frequency in small peptides, that have been implicated in the biologically active conformations of several systems. This report describes the design, synthesis and conformational a
Publikováno v:
Journal of Medicinal Chemistry. 34:3395-3399
Publikováno v:
Synlett. 1991:31-32
Experiments are described which have prompted a revision of the previously proposed Diels-Alder mechanism for the intramolecular cyclization of a 1,2-diacylhydrazine with a 1,3-diene moiety in the presence of (diacetoxyiodo)benzene.
Autor:
Czarnik, Anthony W.
Publikováno v:
Solid Phase Organic Syntheses, Volume 1; 2001, p73-84, 12p
Autor:
Anthony W. Czarnik
The rapid expansion of combinatorial chemistry has renewed interest in solid-phase organic synthesis, a method that lends itself well to creating and screening large numbers of lead compounds. Solid-Phase Organic Syntheses, Volume 1 is the first volu
Autor:
Ogden, Richard C., Flexner, Charles W.
Details the evolution of HIV protease inhibitors from molecular development through medical applications!Considering the latest class of revolutionary drugs fighting against HIV infection and AIDS, this comprehensive reference thoroughly examines the