Zobrazeno 1 - 10
of 145
pro vyhledávání: '"R Alan, Harris"'
Autor:
Jun Wang, Meng Wang, Ala Moshiri, R. Alan Harris, Muthuswamy Raveendran, Tracy Nguyen, Soohyun Kim, Laura Young, Keqing Wang, Roger Wiseman, David H. O’Connor, Zach Johnson, Melween Martinez, Michael J. Montague, Ken Sayers, Martha Lyke, Eric Vallender, Tim Stout, Yumei Li, Sara M. Thomasy, Jeffrey Rogers, Rui Chen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Understanding and treating human diseases require valid animal models. Leveraging the genetic diversity in rhesus macaque populations across eight primate centers in the United States, we conduct targeted-sequencing on 1845 individuals for 3
Externí odkaz:
https://doaj.org/article/3f3b441ea78049f683562adc440c2848
Autor:
Halee Patel, R. Alan Harris, Justin H. Qian, Numan Oezguen, Ashleigh Watson, Reka G. Szigeti, Stanley Cho, Wenly Ruan, Savini Britto, Antone Opekun, Geoffrey Preidis, Richard Kellermayer
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 6, Pp 1069-1071 (2024)
Externí odkaz:
https://doaj.org/article/4ca5b4c214f54b3d9e3c1bac4558f9a5
Autor:
Luis F. Paulin, Muthuswamy Raveendran, R. Alan Harris, Jeffrey Rogers, Arndt von Haeseler, Fritz J. Sedlazeck
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Background Recent population studies are ever growing in number of samples to investigate the diversity of a population or species. These studies reveal new polymorphism that lead to important insights into the mechanisms of evolution, but a
Externí odkaz:
https://doaj.org/article/81963c6bdbee4104820815f627bd4b58
Autor:
Nejla Ozirmak Lermi, Stanton B Gray, Charles M Bowen, Laura Reyes-Uribe, Beth K Dray, Nan Deng, R Alan Harris, Muthuswamy Raveendran, Fernando Benavides, Carolyn L Hodo, Melissa W Taggart, Karen Colbert Maresso, Krishna M Sinha, Jeffrey Rogers, Eduardo Vilar
Publikováno v:
PLoS Genetics, Vol 18, Iss 4, p e1010163 (2022)
Colorectal cancer (CRC) remains the third most common cancer in the US with 15% of cases displaying Microsatellite Instability (MSI) secondary to Lynch Syndrome (LS) or somatic hypermethylation of the MLH1 promoter. A cohort of rhesus macaques from o
Externí odkaz:
https://doaj.org/article/3345afdd7e5447958a5094fe6c001467
Publikováno v:
BMC Evolutionary Biology, Vol 20, Iss 1, Pp 1-12 (2020)
Abstract Background Human chromosome 19 has many unique characteristics including gene density more than double the genome-wide average and 20 large tandemly clustered gene families. It also has the highest GC content of any chromosome, especially ou
Externí odkaz:
https://doaj.org/article/9d4bbc16b4bb456ea3637a79f8341ceb
Autor:
Dan Vanderpool, Bui Quang Minh, Robert Lanfear, Daniel Hughes, Shwetha Murali, R Alan Harris, Muthuswamy Raveendran, Donna M Muzny, Mark S Hibbins, Robert J Williamson, Richard A Gibbs, Kim C Worley, Jeffrey Rogers, Matthew W Hahn
Publikováno v:
PLoS Biology, Vol 18, Iss 12, p e3000954 (2020)
Our understanding of the evolutionary history of primates is undergoing continual revision due to ongoing genome sequencing efforts. Bolstered by growing fossil evidence, these data have led to increased acceptance of once controversial hypotheses re
Externí odkaz:
https://doaj.org/article/89333266269f4ef186dfa850792cc133
Autor:
Marina Brasó-Vives, Inna S Povolotskaya, Diego A Hartasánchez, Xavier Farré, Marcos Fernandez-Callejo, Muthuswamy Raveendran, R Alan Harris, Douglas L Rosene, Belen Lorente-Galdos, Arcadi Navarro, Tomas Marques-Bonet, Jeffrey Rogers, David Juan
Publikováno v:
PLoS Genetics, Vol 16, Iss 5, p e1008742 (2020)
The rhesus macaque is an abundant species of Old World monkeys and a valuable model organism for biomedical research due to its close phylogenetic relationship to humans. Copy number variation is one of the main sources of genomic diversity within an
Externí odkaz:
https://doaj.org/article/671e76d853af4bdd991627866457e9f7
Autor:
Cheng Xue, Navin Rustagi, Xiaoming Liu, Muthuswamy Raveendran, R Alan Harris, Manjunath Gorentla Venkata, Jeffrey Rogers, Fuli Yu
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0236285 (2020)
Characterizing meiotic recombination rates across the genomes of nonhuman primates is important for understanding the genetics of primate populations, performing genetic analyses of phenotypic variation and reconstructing the evolution of human recom
Externí odkaz:
https://doaj.org/article/a4e9decc10074769ba69a27c7b1c9297
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10611
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by hyperandrogenemia of ovarian thecal cell origin, resulting in anovulation/oligo-ovulation and infertility. Our previous studies established that ovarian theca cells isol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::a1f117c2b8d2cc5e97fa53cad62c9567
Autor:
Peter A. Larsen, R. Alan Harris, Yue Liu, Shwetha C. Murali, C. Ryan Campbell, Adam D. Brown, Beth A. Sullivan, Jennifer Shelton, Susan J. Brown, Muthuswamy Raveendran, Olga Dudchenko, Ido Machol, Neva C. Durand, Muhammad S. Shamim, Erez Lieberman Aiden, Donna M. Muzny, Richard A. Gibbs, Anne D. Yoder, Jeffrey Rogers, Kim C. Worley
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-17 (2017)
Abstract Background The de novo assembly of repeat-rich mammalian genomes using only high-throughput short read sequencing data typically results in highly fragmented genome assemblies that limit downstream applications. Here, we present an iterative
Externí odkaz:
https://doaj.org/article/466164a3e1974d34be1c44854c57a46b