Zobrazeno 1 - 10
of 14
pro vyhledávání: '"R A Zivin"'
Autor:
V L Pulito, V A Roberts, J R Adair, A L Rothermel, A M Collins, S S Varga, C Martocello, M Bodmer, L K Jolliffe, R A Zivin
Publikováno v:
The Journal of Immunology. 156:2840-2850
OKT4A, a murine mAb that recognizes an epitope on the CD4 receptor, is a potent immunosuppressive agent in vitro and in a variety of nonhuman primate models of graft rejection and autoimmune disease. Initial human cardiac transplant trials suggest th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf77649c606ea2b414be381a76794a5d
https://doi.org/10.4049/jimmunol.156.8.2840
https://doi.org/10.4049/jimmunol.156.8.2840
Autor:
R. A. Zivin, D R Jeyarajah, L K Jolliffe, Danlin Xu, Husain Sattar, J. R. Thistlethwaite, Maria-Luisa Alegre, K. Kowalkowski, Jeffrey A. Bluestone, L. J. Peterson
Publikováno v:
Transplantation. 57:1537-1543
OKT3, a mouse anti-human CD3 mAb, is a potent immunosuppressive agent used in clinical transplantation to prevent or treat allograft rejection. Associated with this therapy is the systemic release of several cytokines that result in a series of adver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::165d1f0260c1a46d071230905d0b19f2
https://doi.org/10.1097/00007890-199457110-00001
https://doi.org/10.1097/00007890-199457110-00001
Autor:
M L Alegre, A M Collins, V L Pulito, R A Brosius, W C Olson, R A Zivin, R Knowles, J R Thistlethwaite, L K Jolliffe, J A Bluestone
Publikováno v:
The Journal of Immunology. 148:3461-3468
The binding specificity of the murine OKT3 has been transferred into a human antibody framework to reduce its immunogenicity. This "humanized" anti-CD3 mAb (gOKT3-5) was previously shown to retain, in vitro, all the properties of native OKT3, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44f51855c77c66e312d0dec9fdadbbd2
https://doi.org/10.4049/jimmunol.148.11.3461
https://doi.org/10.4049/jimmunol.148.11.3461
Publikováno v:
European journal of biochemistry. 268(22)
p38 mitogen-activated protein kinase (MAPK) (p38/p38-alpha/CSBP2/RK) has been implicated in the regulation of many proinflammatory pathways. Because of this, it has received much attention as a potential drug target for controlling diseases such as r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2a16a5a09a8298b0a9bef27e6ee3071f
https://pubmed.ncbi.nlm.nih.gov/11722559
https://pubmed.ncbi.nlm.nih.gov/11722559
Autor:
M E, Burczynski, M, McMillian, J B, Parker, S, Bryant, A, Leone, E R, Grant, J M, Thorne, Z, Zhong, R A, Zivin, M D, Johnson
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(9)
The acceleration of drug discovery due to combinatorial chemistry and high-throughput screening methods has increased the numbers of candidate pharmaceuticals entering the drug development phase, and the capability to accurately predict whether drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8a95d1f9427b4ce9b3ccec8434e618da
https://pubmed.ncbi.nlm.nih.gov/11502735
https://pubmed.ncbi.nlm.nih.gov/11502735
Autor:
E R, Grant, M A, Errico, S L, Emanuel, D, Benjamin, M K, McMillian, S A, Wadsworth, R A, Zivin, Z, Zhong
Publikováno v:
Biochemical pharmacology. 62(3)
Excessive levels of the neurotransmitter glutamate trigger excitotoxic processes in neurons that lead to cell death. N-Methyl-D-aspartate (NMDA) receptor over-activation is a key excitotoxic stimulus that leads to increases in intracellular calcium a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::347ec9deb4610e812ab8d118d1e1a739
https://pubmed.ncbi.nlm.nih.gov/11434901
https://pubmed.ncbi.nlm.nih.gov/11434901
Autor:
J. Charette, Julie A. Auger, Haverty T, Jeffrey A. Bluestone, E. S. Woodle, Donna Peace, Thistlethwaite, R. A. Zivin, O'Laughlin R, Xu D, Jollife Lk
Publikováno v:
Transplantation. 68(5)
Background HuOKT3gamma1(Ala-Ala) is a genetically-engineered derivative of the parental murine OKT3 monoclonal antibody, in which the six complementarity-determining regions have been grafted within a human IgG1 mAb, and whose C(H)2 region has been a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7ae0b6474308f917bb42156d8a1785
https://pubmed.ncbi.nlm.nih.gov/10507477
https://pubmed.ncbi.nlm.nih.gov/10507477
Autor:
V L, Pulito, V A, Roberts, J R, Adair, A L, Rothermel, A M, Collins, S S, Varga, C, Martocello, M, Bodmer, L K, Jolliffe, R A, Zivin
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 156(8)
OKT4A, a murine mAb that recognizes an epitope on the CD4 receptor, is a potent immunosuppressive agent in vitro and in a variety of nonhuman primate models of graft rejection and autoimmune disease. Initial human cardiac transplant trials suggest th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bea1cddbebff22ca3395c90c192cfb19
https://pubmed.ncbi.nlm.nih.gov/8609403
https://pubmed.ncbi.nlm.nih.gov/8609403
Autor:
M L, Alegre, L J, Peterson, D, Xu, H A, Sattar, D R, Jeyarajah, K, Kowalkowski, J R, Thistlethwaite, R A, Zivin, L, Jolliffe, J A, Bluestone
Publikováno v:
Transplantation. 57(11)
OKT3, a mouse anti-human CD3 mAb, is a potent immunosuppressive agent used in clinical transplantation to prevent or treat allograft rejection. Associated with this therapy is the systemic release of several cytokines that result in a series of adver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cf78403a1bf883ba908d09e69bfe6621
https://pubmed.ncbi.nlm.nih.gov/8009586
https://pubmed.ncbi.nlm.nih.gov/8009586
Autor:
M L, Alegre, A M, Collins, V L, Pulito, R A, Brosius, W C, Olson, R A, Zivin, R, Knowles, J R, Thistlethwaite, L K, Jolliffe, J A, Bluestone
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 148(11)
The binding specificity of the murine OKT3 has been transferred into a human antibody framework to reduce its immunogenicity. This "humanized" anti-CD3 mAb (gOKT3-5) was previously shown to retain, in vitro, all the properties of native OKT3, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1fab241d9e72c91c15fc9c298f37a405
https://pubmed.ncbi.nlm.nih.gov/1534096
https://pubmed.ncbi.nlm.nih.gov/1534096