Výsledky vyhledávání

Replication of human cytomegalovirus in cells deficient in beta2-microglobulin gene expression

Autor: Qian Wu, J. D. Shanley, S. J. Forman, R. J. Tatake, R. A. Zeff, W. Trymbulak

Publikováno v: Journal of General Virology. 75:2755-2759

To study the roles of beta 2-microglobulin (beta 2-m) and major histocompatibility complex (MHC) class I expression in human cytomegalovirus (HCMV) infection, the ability of HCMV strain AD-169 to infect and replicate in a human melanoma cell line (FO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7cb863e5ff62c6ac558e812e94589aa
https://doi.org/10.1099/0022-1317-75-10-2755

Zobrazit plný text záznamu

Reduction in susceptibility to natural killer cell-mediated lysis of human FO-1 melanoma cells after induction of HLA class I antigen expression by transfection with B2m gene

Autor: Soldano Ferrone, Maresa Altomonte, R A Zeff, Michele Maio, R. Tatake

Publikováno v: Journal of Clinical Investigation. 88:282-289

Induction of HLA class I antigens on cultured melanoma cells FO-1 after transfection with a human or a mouse B2m gene was associated with a statistically significant reduction in their susceptibility to natural killer (NK) cell-mediated lysis. These

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69993138a0f0da502f56331427a306a4
https://doi.org/10.1172/jci115289

Zobrazit plný text záznamu

Cytokine regulation of IL-1 beta gene expression in the human polymorphonuclear leukocyte

Autor: P T Marucha, R A Zeff, D L Kreutzer

Publikováno v: The Journal of Immunology. 145:2932-2937

Although recently polymorphonuclear leukocytes (PMN) have been identified as producers of IL-1 beta in response to LPS and granulocyte/monocyte colony stimulating factor, little is known regarding the ability of other cytokines to induce the producti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35cb5437623431fa54f50d6f039bbb74
https://doi.org/10.4049/jimmunol.145.9.2932

Zobrazit plný text záznamu

Mutants of human beta2-microglobulin map an immunodominant epitope within the three-stranded beta-pleated sheet

Autor: W P, Trymbulak, R A, Zeff

Publikováno v: Transplantation. 64(4)

Genetically engineered structural variants of human beta2-microglobulin (beta2m) were produced by sequence exchange with mouse beta2m for the purpose of examining species-specific antigenic determinant expression. For aggregate mapping, mouse and hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::833523ba9ae73b84eba4c47609c36373
https://pubmed.ncbi.nlm.nih.gov/9293879

Zobrazit plný text záznamu

Tissue factor expression in human leukocytes and tumor cells

Autor: F R, Rickles, G A, Hair, R A, Zeff, E, Lee, R D, Bona

Publikováno v: Thrombosis and haemostasis. 74(1)

Tissue factor (TF) exists in a cryptic form [i.e. without procoagulant activity (PCA)] in peripheral blood monocytes and quiescent tissue macrophages but is expressed constitutively in most human tumor cells. Induction and cell surface expression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::984d5f9983d7ed68191322fd89ffdbaa
https://pubmed.ncbi.nlm.nih.gov/8578492

Zobrazit plný text záznamu

Failure in expression of structurally altered (CYS164--TYR) H-2Kb molecules is mitigated with high affinity peptide-ligand

Autor: R J, Tatake, R A, Zeff

Publikováno v: Transplantation. 59(9)

A C164Y somatic mutation in the H-2Kb class I molecule causes a disruption of the alpha 2 domain disulfide bond and results in a loss of H-2Kb cell surface expression by the 69.9.15 cell line. In vitro culture of the somatic cell variant at 30 degree

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::34f69b8501cd1717485c60ee27d500a6
https://pubmed.ncbi.nlm.nih.gov/7762072

Zobrazit plný text záznamu

Differential effect of human and mouse beta 2-microglobulin on the induction and the antigenic profile of endogenous HLA-A and -B antigens synthesized by beta 2-microglobulin gene-null FO-1 melanoma cells

Autor: Z, Wang, X Z, Hu, R J, Tatake, S Y, Yang, R A, Zeff, S, Ferrone

Publikováno v: Cancer research. 53(18)

beta 2-Microglobulin (beta 2-mu) gene-null human melanoma FO-1 cells display lower reactivity with anti-HLA class I monoclonal antibodies (mAb) following transfection with a wild-type mouse beta 2-mu gene (referred to as FO-1C cells) than following t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ebe1363f5d5eb4b5a9ce6db18a31f4a3
https://pubmed.ncbi.nlm.nih.gov/7689931

Zobrazit plný text záznamu

Lack of HLA class I antigen expression by melanoma cells SK-MEL-33 caused by a reading frameshift in beta 2-microglobulin messenger RNA

Autor: A. P. Albino, Alan N. Houghton, Soldano Ferrone, Yan Cao, R A Zeff, Zhigang Wang

The lack of HLA class I antigen expression by the melanoma cell line SK-MEL-33 is caused by a unique lesion in beta 2-microglobulin (beta 2-mu). Sequencing of beta 2-mu mRNA detected a guanosine deletion at position 323 in codon 76 that causes a fram

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a5d1a0fb73918e9ec53dffa4f8ecb2
https://europepmc.org/articles/PMC288010/

Zobrazit plný text záznamu

Cytokine-induced IL-1 beta gene expression in the human polymorphonuclear leukocyte: transcriptional and post-transcriptional regulation by tumor necrosis factor and IL-1

Autor: P T, Marucha, R A, Zeff, D L, Kreutzer

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 147(8)

We have previously demonstrated that Il-1 and TNF could rapidly, but transiently, induce gene expression of Il-1 beta in human polymorphonuclear leukocytes (PMN) at both the protein and mRNA level. Additionally, we demonstrated a cooperative effect o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::78164a9952ed90c955c5e48d1ec42e4d
https://pubmed.ncbi.nlm.nih.gov/1918980

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání