Výsledky vyhledávání - "R A Mariuzza"

Structural basis of MHC class I recognition by natural killer cell receptors

Autor: M W, Sawicki, N, Dimasi, K, Natarajan, J, Wang, D H, Margulies, R A, Mariuzza

Publikováno v: Immunological reviews. 181

Natural killer (NK)-cell function is regulated by NK receptors that recognize MHC class I (MHC-I) molecules on target cells. Two structurally distinct families of NK receptors have been identified, the immunoglobulin-like family (killer cell immunogl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9aa123a7f2396fe730bd70cb180fa56b
https://pubmed.ncbi.nlm.nih.gov/11513152

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High affinity T cell receptors from yeast display libraries block T cell activation by superantigens

Autor: M C, Kieke, E, Sundberg, E V, Shusta, R A, Mariuzza, K D, Wittrup, D M, Kranz

Publikováno v: Journal of molecular biology. 307(5)

The alphabeta T cell receptor (TCR) can be triggered by a class of ligands called superantigens. Enterotoxins secreted by bacteria act as superantigens by simultaneously binding to an MHC class II molecule on an antigen- presenting cell and to a TCR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::996968247c7fc2fb5666ad4c791b0511
https://pubmed.ncbi.nlm.nih.gov/11292343

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Superantigen recognition by gammadelta T cells: SEA recognition site for human Vgamma2 T cell receptors

Autor: C T, Morita, H, Li, J G, Lamphear, R R, Rich, J D, Fraser, R A, Mariuzza, H K, Lee

Publikováno v: Immunity. 14(3)

Human gammadelta T cells expressing the Vgamma2Vdelta2 antigen receptors recognize nonpeptide prenyl pyrophosphate and alkylamine antigens. We find that they also recognize staphylococcal enterotoxin A superantigens in a manner distinct from the reco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb60e7b0c127382fd41e784c233530af
https://pubmed.ncbi.nlm.nih.gov/11290341

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MHC class I molecules, structure and function

Autor: K, Natarajan, H, Li, R A, Mariuzza, D H, Margulies

Publikováno v: Reviews in immunogenetics. 1(1)

MHC class I molecules (MHC-I) are cell surface recognition elements expressed on virtually all somatic cells. These molecules sample peptides generated within the cell and signal the cell's physiological state to effector cells of the immune system,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::645ca260e6ebfe489a4204f0db43d229
https://pubmed.ncbi.nlm.nih.gov/11256571

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Structure of the Vdelta domain of a human gammadelta T-cell antigen receptor

Autor: H, Li, M I, Lebedeva, A S, Llera, B A, Fields, M B, Brenner, R A, Mariuzza

Publikováno v: Nature. 391(6666)

Antigen recognition by T lymphocytes is mediated by cell-surface glycoproteins known as T-cell antigen receptors (TCRs). These are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. In contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::276cf32f271bfd24bfca902cbb899c6e
https://pubmed.ncbi.nlm.nih.gov/9461220

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Dual conformations of a T cell receptor V alpha homodimer: implications for variability in V alpha V beta domain association

Autor: H, Li, M I, Lebedeva, E S, Ward, R A, Mariuzza

Publikováno v: Journal of molecular biology. 269(3)

The crystal structure of a mutant T cell receptor (TCR) V alpha domain containing a grafted third complementarity-determining region (CDR3) from a different V alpha was determined at 2.3 A resolution by molecular replacement using the wild-type V alp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fbef50a2f32ceebac90ff724a19446b6
https://pubmed.ncbi.nlm.nih.gov/9199407

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Cloning, expression, and crystallization of the V delta domain of a human gamma delta T-cell receptor

Autor: M I, Lebedeva, B A, Fields, H, Spits, G, Panchamoorthy, M B, Brenner, R A, Mariuzza

Publikováno v: Protein science : a publication of the Protein Society. 5(12)

T-lymphocytes recognize a wide variety of antigens through highly diverse cell-surface glycoproteins known as T-cell receptors (TCRs). These disulfide-linked heterodimers are composed of alpha and beta or gamma and delta polypeptide chains consisting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dfb56223463456375dc5d800144ed600
https://pubmed.ncbi.nlm.nih.gov/8976572

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The effect of water activity on the association constant and the enthalpy of reaction between lysozyme and the specific antibodies D1.3 and D44.1

Autor: F A, Goldbaum, F P, Schwarz, E, Eisenstein, A, Cauerhff, R A, Mariuzza, R J, Poljak

Publikováno v: Journal of molecular recognition : JMR. 9(1)

The reactions of lysozyme with the specific monoclonal antibody D1.3, its Fv fragment and a mutant of the Fv, were studied under conditions of reduced water activity through the addition of the cosolutes glycerol, ethanol, dioxane and methanol. Titra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::42c1904fadf326d5472290a82c36615e
https://pubmed.ncbi.nlm.nih.gov/8723314

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Thermodynamics of antigen-antibody binding using specific anti-lysozyme antibodies

Autor: F P, Schwarz, D, Tello, F A, Goldbaum, R A, Mariuzza, R J, Poljak

Publikováno v: European journal of biochemistry. 228(2)

Titration calorimetry measurements on the binding of hen lysozyme to the specific monoclonal IgG antibodies D1.3, D11.15, D44.1, F9.13.7, F10.6.6, their papain-cleaved antigen binding fragments (Fab) and their protein-engineered fragments consisting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e009c46a20b5064534588e6b9fea3da6
https://pubmed.ncbi.nlm.nih.gov/7705353

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