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Stimulation of tumor-draining lymph node cells with superantigenic staphylococcal toxins leads to the generation of tumor-specific effector T cells

Autor: S Shu, R A Krinock, T Matsumura, J J Sussman, B A Fox, A E Chang, D S Terman

Publikováno v: The Journal of Immunology. 152:1277-1288

In animal studies, lymph nodes (LN) draining progressive tumors contain immunologically sensitized but functionally deficient T cells. These preeffector cells can differentiate into mature effector cells on stimulation in vitro with anti-CD3 and IL-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0dd261701f8adedd919bf588d3fcf2f
https://doi.org/10.4049/jimmunol.152.3.1277

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Characteristics and in vivo homing of long-term T-cell lines and clones derived from tumor-draining lymph nodes

Autor: T, Matsumura, J J, Sussman, R A, Krinock, A E, Chang, S, Shu

Publikováno v: Cancer research. 54(10)

Lymph nodes draining a progressively growing tumor contain T-cells which can be activated sequentially by anti-CD3 and IL-2 to differentiate into tumor-specific effector cells. In this study, long-term cultured T-cell lines were established from acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1ae4ee3b0c6ccbf7b1dcafdbf680f001
https://pubmed.ncbi.nlm.nih.gov/8168105

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Stimulation of tumor-draining lymph node cells with superantigenic staphylococcal toxins leads to the generation of tumor-specific effector T cells

Autor: S, Shu, R A, Krinock, T, Matsumura, J J, Sussman, B A, Fox, A E, Chang, D S, Terman

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 152(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e9517c771654ef37ca750821a08719de
https://pubmed.ncbi.nlm.nih.gov/8301131

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Cross-reactivity of anti-CD3/IL-2 activated effector cells derived from lymph nodes draining heterologous clones of a murine tumor

Autor: T, Matsumura, R A, Krinock, A E, Chang, S, Shu

Publikováno v: Cancer research. 53(18)

Cells from lymph nodes (LN) draining progressively growing tumors can differentiate into immune effector cells upon in vitro stimulation with anti-CD3 monoclonal antibodies followed by interleukin-2. The adoptive transfer of these activated LN cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f833a69101995db258c25a6cab347d75
https://pubmed.ncbi.nlm.nih.gov/8364926

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