Zobrazeno 1 - 10
of 164
pro vyhledávání: '"R A John, Challiss"'
Autor:
Susan W Robinson, Julie-Myrtille Bourgognon, Jereme G Spiers, Carlo Breda, Susanna Campesan, Adrian Butcher, Giovanna R Mallucci, David Dinsdale, Nobuhiro Morone, Raj Mistry, Tim M Smith, Maria Guerra-Martin, R A John Challiss, Flaviano Giorgini, Joern R Steinert
Publikováno v:
PLoS Biology, Vol 16, Iss 4, p e2003611 (2018)
Nitric oxide (NO) regulates neuronal function and thus is critical for tuning neuronal communication. Mechanisms by which NO modulates protein function and interaction include posttranslational modifications (PTMs) such as S-nitrosylation. Importantl
Externí odkaz:
https://doaj.org/article/9e9cf68bba724e81a075808600ab4057
Autor:
Neil M. Nathanson, Jürgen Wess, Rudolf Hammer, R. A. John Challiss, Richard M. Eglen, Fred Mitchelson, David Brown, Sophie J. Bradley, Celine Valant, Heinz Kilbinger, Chris Langmead, Frederick J. Ehlert, Andrew B. Tobin, Noel J. Buckley, Ernst Mutschler, Günter Lambrecht, Arthur Christopoulos, David M. Thal, Roy D. Schwarz, Nigel J. M. Birdsall, Christian C. Felder
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [50]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21748271f1e349fb133f34951200f47b
https://doi.org/10.2218/gtopdb/f2/2021.3
https://doi.org/10.2218/gtopdb/f2/2021.3
Autor:
Jennifer L Brignell, Matthew D Perry, Carl P Nelson, Jonathon M Willets, R A John Challiss, Noel W Davies
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121285 (2015)
Voltage-gated potassium channels (Kv) are important regulators of membrane potential in vascular smooth muscle cells, which is integral to controlling intracellular Ca2+ concentration and regulating vascular tone. Previous work indicates that Kv chan
Externí odkaz:
https://doaj.org/article/8060799ea73e44bbbde8e72d7af1eed2
Autor:
Frederick J. Ehlert, Nigel J. M. Birdsall, Ernst Mutschler, Heinz Kilbinger, Günter Lambrecht, Neil M. Nathanson, Roy D. Schwarz, Sophie J. Bradley, Richard M. Eglen, Christian C. Felder, David M. Thal, R. A. John Challiss, Rudolf Hammer, Andrew B. Tobin, Jürgen Wess, Arthur Christopoulos, Celine Valant, Noel J. Buckley, Fred Mitchelson, David Brown, Chris Langmead
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [50]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8bba16c5815dfeddf5c98ecc587ad10
https://doi.org/10.2218/gtopdb/f2/2021.2
https://doi.org/10.2218/gtopdb/f2/2021.2
Autor:
Mario Rossi, R. A. John Challiss, Colin Molloy, Eyassu Chernet, Sophie J. Bradley, Paulina Valuskova, Lisa M. Broad, Adrian J. Mogg, Karolina Gherbi, Vanessa N. Barth, Elizabeth M. Rosethorne, Andrew B. Tobin, Arthur Christopoulos, Caroline A. Wilson, Lisa Finlayson, Louis Dwomoh, Miriam Scarpa, Rajendra Mistry, Shuzo Sakata, Patrick M. Sexton, Kjell A. Svensson, David A. Sykes
Cholinesterase inhibitors, the current frontline symptomatic treatment for Alzheimer’s disease (AD), are associated with low efficacy and adverse effects. M1 muscarinic acetylcholine receptors (M1 mAChRs) represent a potential alternate therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e98a59cb796f11c7703f6b34d2e88b3
https://strathprints.strath.ac.uk/71527/1/Bradley_etal_NCB_2019_Biased_M1_muscarinic_receptor_mutant_mice_inform.pdf
https://strathprints.strath.ac.uk/71527/1/Bradley_etal_NCB_2019_Biased_M1_muscarinic_receptor_mutant_mice_inform.pdf
Autor:
Danijela Markovic, Jonathan Holdich, Suleiman Al-Sabah, Rajendra Mistry, Cornelius Krasel, Martyn P Mahaut-Smith, R A John Challiss
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29946 (2012)
Muscarinic acetylcholine receptors (mAChRs) are 7-transmembrane, G protein-coupled receptors that regulate a variety of physiological processes and represent potentially important targets for therapeutic intervention. mAChRs can be stimulated by full
Externí odkaz:
https://doaj.org/article/6f2ae794a82940a8b0a3ea346afcd0b3
Autor:
Elena Christofidou, R. A. John Challiss, Craig A. Nash, Christian Moeller-Olsen, Carl P. Nelson, Rajendra Mistry, Jonathon M. Willets
Publikováno v:
Cellular Signalling. 51:86-98
Generation of cAMP through Gs-coupled G protein-coupled receptor (GPCR) [e.g. β2-adrenoceptor (β2AR), adenosine A2B receptor (A2BR)] activation, induces arterial smooth muscle relaxation, counteracting the actions of vasoconstrictors. Gs-coupled GP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b82b98e018d6fc50656b6fc8bdbecd
https://doi.org/10.1016/j.cellsig.2018.07.013
https://doi.org/10.1016/j.cellsig.2018.07.013
Publikováno v:
Molecular Pharmacology. 94:674-688
The structurally related, but distinct neuropeptides, neuromedin U (NmU) and neuromedin S (NmS) are ligands of two G protein-coupled NmU receptors (NMU1 and NMU2). Hypothalamic NMU2 regulates feeding behavior and energy expenditure and has therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e23a76f6e04a99d00f270398d353c7
https://doi.org/10.1124/mol.117.111070
https://doi.org/10.1124/mol.117.111070
Autor:
René A W Frank, Allan F McRae, Andrew J Pocklington, Louie N van de Lagemaat, Pau Navarro, Mike D R Croning, Noboru H Komiyama, Sophie J Bradley, R A John Challiss, J Douglas Armstrong, Robert D Finn, Mary P Malloy, Alan W MacLean, Sarah E Harris, John M Starr, Sanjeev S Bhaskar, Eleanor K Howard, Sarah E Hunt, Alison J Coffey, Venkatesh Ranganath, Panos Deloukas, Jane Rogers, Walter J Muir, Ian J Deary, Douglas H Blackwood, Peter M Visscher, Seth G N Grant
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19011 (2011)
Current models of schizophrenia and bipolar disorder implicate multiple genes, however their biological relationships remain elusive. To test the genetic role of glutamate receptors and their interacting scaffold proteins, the exons of ten glutamater
Externí odkaz:
https://doaj.org/article/fc8f88c9f5314babada323faa5b3d351