P1262: EZH2 INHIBITORS MEDIATE PLATINUM RESISTANCE BY ENHANCED EFFLUX

Autor: E. Groß, R.-A. Hilger, J. Wehde, F. L. Schümann, C. Rohde, E. Willscher, J. Lützkendorf, L. P. Müller, B. Edemir, T. Müller, M. Binder, G. Posern, T. Weber

Publikováno v: HemaSphere, Vol 6, Pp 1147-1148 (2022)

Externí odkaz: https://doaj.org/article/6abd58892d124e7cbf164c371fba1f51

Ablehnbereich

Autor: R.-D. Hilger, N. Heussen, S. Stanzel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f10feab926fc85f5f095a18d207785d
https://doi.org/10.1007/978-3-662-48986-4_67

Safety, tolerability and pharmacokinetic properties of the novel triazene TriN 2755 in tumour bearing dogs - a phase I study†

Autor: R. A. Hilger, Caroline Geigy, Valeria Meier, I. Athanasiadi, C. Rohrer Bley

Publikováno v: Veterinary and Comparative Oncology. 15:94-104

TriN 2755 is an alkylating antineoplastic agent for intravenous (IV) use, carrying the triazene group as the cytotoxic principal. Using a standard 3 + 3 design, a phase I study was performed in tumour bearing dogs to determine the maximum tolerated d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d492a8b5a2325c3e4db10413e5e6e8e9
https://doi.org/10.1111/vco.12145

Dose-escalated treosulphan in combination with cyclophosphamide as a new preparative regimen for allogeneic haematopoietic stem cell transplantation in patients with an increased risk for regimen-related complications

Autor: D. W. Beelen, Axel A. Fauser, Nadezda Basara, R A Hilger, Mathias Freund, Joachim Hahn, M E Scheulen, Rudolf Trenschel, Jochen Casper, Joachim Baumgart, Bernd Hertenstein, Ernst Holler, Heidrun A. Mylius, Uwe Pichlmeier

Publikováno v: Bone Marrow Transplantation. 35:233-241

Treosulphan has recently demonstrated antileukaemic activity and potent haematopoietic stem cell toxicity. Dose-escalated treosulphan (3 x 12 or 3 x 14 g/m2) combined with cyclophosphamide (Cy) was chosen for a new preparative regimen before allogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5eaac511aee5507015b8bc5ff2d1589
https://doi.org/10.1038/sj.bmt.1704784

CLINICAL TRIALS

Autor: S. Tippelt, R. Mikasch, M. Warmuth-Metz, T. Pietsch, R. A. Hilger, R. Kwiecien, A. Faldum, S. Rutkowski, U. Bode, N. Siegler, G. Fleischhack, C. Dufour, M.-B. Delisle, A. Geoffray, A. Laplanche, D. Frappaz, C. Icher, A.-I. Bertozzi, P. Leblond, F. Doz, N. Andre, P. Schneider, E. De Carli, C. Berger, O. Lejars, P. Chastagner, C. Soler, N. Entz-Werle, D. Valteau-Couanet, S. Burzynski, T. Janicki, G. Burzynski, A. Marszalek, A. Deiss, A. Korshunov, D. Capper, H. Witt, C. van Tilburg, A. von Deimling, A. E. Kulozik, S. M. Pfister, O. Witt, T. Milde, G. Dhall, K. Haley, J. Finlay, T. Rushing, R. Sposto, R. Seeger, R. R. Lulla, S. Goldman, C. Beattie, T. K. DasGupta, I. Pollack, P. G. Fisher, S. Wu, J. M. Boyett, M. Fouladi, L. Meijer, G. Veal, D. Walker, R. Grundy, W. Konczalik, D. Ivanov, M. Garnett, T. Parker, P. Kearns, R. Rahman, S. Smith, M. Kimpo, B. Yan, C. Ning, M. Villegas, A. P. Alcasabas, Y. E. Juh, Q. T. Chong, T. P. Lin, M. Dewire, R. Drissi, L. Chow, A. Pai, J. Leach, A. Lane, L. Backus, L. Grimme, J. Tabares, S. Kumar, M. Sobo, T. R. Hummel, M. Alharbi, S. Abdullah, Q. Alharbi, M. Alshahrani, O. Mosleh, A. Balbaid, A. Alkofide, N. Alkhayat, K. AlFar, A. Banyhamdan, O. Ahmed, S. El-Badawy, E. Bouffet, M.-w. Jiang, R.-h. Zhou, Q. Zhou, X.-j. Yuan, J. Ma, D. Turner, K. Wright, A. Broniscer, G. Robinson, I. Qaddoumi, G. Armstrong, A. Gajjar, C. Stewart, S. N. Misra, A. K. Misra, A. Michalski, C. Stiller

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee575195926d843755d1305b195e437
https://europepmc.org/articles/PMC4046282/