Zobrazeno 1 - 10
of 135
pro vyhledávání: '"R A Broughton"'
Autor:
Yifang Li, Alex Hunter, Miqdad M. Wakeel, Guizhi Sun, Ricky W. K. Lau, Brad R. S. Broughton, Ivan E. Oyarce Pino, Zihao Deng, Tingfang Zhang, Padma Murthi, Mark P. Del Borgo, Robert E. Widdop, Jose M. Polo, Sharon D. Ricardo, Chrishan S. Samuel
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Background Kidney fibrosis is a hallmark of chronic kidney disease (CKD) and compromises the viability of transplanted human bone marrow-derived mesenchymal stromal cells (BM-MSCs). Hence, BM-MSCs were genetically-engineered to express the a
Externí odkaz:
https://doaj.org/article/d6c0ff1090e149c8a2dd546898ac8e05
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The photothrombotic stroke model relies on the interaction between photosensitive-dye and light for clot formation. Interestingly, the relationship between the length of light exposure and stroke-outcome has never been examined. This model h
Externí odkaz:
https://doaj.org/article/1e4c1c51fead401398d34fd1805ae521
Autor:
Jason S. Palazzolo, Anukreity Ale, Heidi Ho, Shweta Jagdale, Brad R. S. Broughton, Robert L. Medcalf, David K. Wright, Karen Alt, Christoph E. Hagemeyer, Be’eri Niego
Publikováno v:
Blood Advances. 7:561-574
Thrombolysis with tissue-type plasminogen activator (tPA) remains the main treatment for acute ischemic stroke. Nevertheless, tPA intervention is limited by a short therapeutic window, low recanalization rates, and a risk of intracranial hemorrhage (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbfeb18418f9e7ea36aa9352c884e50b
https://doi.org/10.1182/bloodadvances.2021006691
https://doi.org/10.1182/bloodadvances.2021006691
Publikováno v:
Fluids and Barriers of the CNS, Vol 14, Iss 1, Pp 1-11 (2017)
Abstract Background Symptomatic intracerebral haemorrhage (sICH) following tissue-type plasminogen activator (rt-PA) administration is the most feared and lethal complication of thrombolytic therapy for ischaemic stroke, creating a significant obstac
Externí odkaz:
https://doaj.org/article/5cc7a82c01434da8a40932debbe083aa
Autor:
Eunice E. To, Ross Vlahos, Raymond Luong, Michelle L. Halls, Patrick C. Reading, Paul T. King, Christopher Chan, Grant R. Drummond, Christopher G. Sobey, Brad R. S. Broughton, Malcolm R. Starkey, Renee van der Sluis, Sharon R. Lewin, Steven Bozinovski, Luke A. J. O’Neill, Tim Quach, Christopher J. H. Porter, Doug A. Brooks, John J. O’Leary, Stavros Selemidis
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Production of reactive oxygen species is an ancient antimicrobial mechanism, but its role in antiviral defense in mammals is unclear. Here, To et al. show that virus infection activates endosomal NOX2 oxidase and restricts TLR7 signaling, and that an
Externí odkaz:
https://doaj.org/article/1631134d108f482a9e7cb5b0a4cfdc77
Autor:
N. Chapman, F. Z. Marques, D. S. Picone, A. Adji, B. R. S. Broughton, Q. N. Dinh, G. Gabb, G. W. Lambert, A. S. Mihailidou, M. R. Nelson, M. Stowasser, M. Schlaich, M. G. Schultz, J. P. Mynard, R. E. Climie
Publikováno v:
Journal of Human Hypertension.
Blood pressure(BP) management interventions have been shown to be more effective when accompanied by appropriate patient education. As high BP remains poorly controlled, there may be gaps in patient knowledge and education. Therefore, this study aime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2ed85566fec95fcac4387f12f9c548a
https://doi.org/10.1038/s41371-022-00723-8
https://doi.org/10.1038/s41371-022-00723-8
Autor:
Shirley H T, Truong, Benjamin, Bonnici, Samoda, Rupasinghe, Barbara K, Kemp-Harper, Chrishan S, Samuel, Brad R S, Broughton
Publikováno v:
SSRN Electronic Journal.
Brain inflammation and apoptosis contribute to neuronal damage and loss following ischaemic stroke, leading to cognitive and functional disability. It is well-documented that the human gene-2 (H2)-relaxin hormone exhibits pleiotropic properties via i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27851fcd53bc61abf679dcf3d73a07df
https://doi.org/10.2139/ssrn.4182820
https://doi.org/10.2139/ssrn.4182820
Autor:
N, Chapman, F Z, Marques, D S, Picone, A, Adji, B R S, Broughton, Q N, Dinh, G, Gabb, G W, Lambert, A S, Mihailidou, M R, Nelson, M, Stowasser, M, Schlaich, M G, Schultz, J P, Mynard, R E, Climie
Publikováno v:
Journal of human hypertension.
Blood pressure(BP) management interventions have been shown to be more effective when accompanied by appropriate patient education. As high BP remains poorly controlled, there may be gaps in patient knowledge and education. Therefore, this study aime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f8de3f076ae4cdac87aabf1ed986f6a
https://pubmed.ncbi.nlm.nih.gov/35948655
https://pubmed.ncbi.nlm.nih.gov/35948655
Publikováno v:
Journal of Engineered Fibers and Fabrics, Vol 2, Iss 4, Pp 25-32 (2007)
Cellulose and m-aramid were dissolved in an ionic liquid, and dry-jet wet spinning was employed to prepare composite fibers which could be rendered antimicrobial through exposure to chlorine bleach. The small domains of the m-aramid allowed a much hi
Externí odkaz:
https://doaj.org/article/f4b4ace0658747368ddb900d9b43d068
Autor:
Paul T King, Roleen Sharma, Kim O'Sullivan, Stavros Selemidis, Steven Lim, Naghmeh Radhakrishna, Camden Lo, Jyotika Prasad, Judy Callaghan, Peter McLaughlin, Michael Farmer, Daniel Steinfort, Barton Jennings, James Ngui, Bradley R S Broughton, Belinda Thomas, Ama-Tawiah Essilfie, Michael Hickey, Peter W Holmes, Philip Hansbro, Philip G Bardin, Stephen R Holdsworth
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120371 (2015)
Nontypeable Haemophilus influenzae (NTHi) is a prevalent bacterium found in a variety of chronic respiratory diseases. The role of this bacterium in the pathogenesis of lung inflammation is not well defined. In this study we examined the effect of NT
Externí odkaz:
https://doaj.org/article/2c10d59797b34610a811b91fc9d1f67b