Zobrazeno 1 - 10
of 27
pro vyhledávání: '"R A, Yokel"'
Autor:
R A, Yokel
Publikováno v:
Neurotoxicology. 21(5)
Aluminum is environmentally ubiquitous, providing human exposure. Usual human exposure is primarily dietary. The potential for significant Al absorption from the nasal cavity and direct distribution into the brain should be further investigated. Decr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fff76600366666904b1f4de5cbc514fd
https://pubmed.ncbi.nlm.nih.gov/11130287
https://pubmed.ncbi.nlm.nih.gov/11130287
Publikováno v:
Journal of pharmaceutical sciences. 89(4)
Bidentate hydroxypyridinone chelators effectively complex and facilitate excretion of trivalent iron. To test the hypothesis that hexadentate chelators are more effective than bidentate chelators at low concentrations, urinary and biliary Fe excretio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c1f5cee7c1d04f0b09c5990a0b3c1158
https://pubmed.ncbi.nlm.nih.gov/10737916
https://pubmed.ncbi.nlm.nih.gov/10737916
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 25(2)
The objectives of the present study were to determine the efficacy and toxicity of repeated oral administration of 3-hydroxypyridin-4-one (HP) chelators in a rabbit model of aluminum (Al) accumulation and toxicity, and the influence of chelator lipop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::af7ceccc4a556ad07e4d5d76e13fcef9
https://pubmed.ncbi.nlm.nih.gov/9029049
https://pubmed.ncbi.nlm.nih.gov/9029049
Publikováno v:
Journal of toxicology and environmental health. 48(6)
In this study of the toxicokinetics of aluminum we have examined some of the fundamental issues that currently define our understanding of the toxicology of aluminum in humans. There is a vast literature on this subject, and it was not our aim to rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e305deca511bc06dd6a5107dc089ce
https://pubmed.ncbi.nlm.nih.gov/8772799
https://pubmed.ncbi.nlm.nih.gov/8772799
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(1)
This study was conducted to assess the influence of lipophilicity on the in vivo aluminum (Al) chelation activity of 3-hydroxypyridin-4-ones (HPs). Chelation activity was evidenced as increased Al elimination in an animal model of Al accumulation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a051e812f9621d8d198960409c71982
https://pubmed.ncbi.nlm.nih.gov/8825197
https://pubmed.ncbi.nlm.nih.gov/8825197
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::deddccc9d02a6fe1f2dcbeb9821bfd54
https://pubmed.ncbi.nlm.nih.gov/8654208
https://pubmed.ncbi.nlm.nih.gov/8654208
Publikováno v:
Neurotoxicology. 16(3)
Free radical-induced brain oxidative injury is thought to play a role in the etiology and pathogenesis of neurodegenerative disorders. Iron (Fe) can catalyze the Fenton reaction and mediate hydroxyl radical (HO.) generation to initiate lipid peroxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7277047ab7ed5bbce67f04ab14fd88b1
https://pubmed.ncbi.nlm.nih.gov/8584280
https://pubmed.ncbi.nlm.nih.gov/8584280
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 21(2)
Selected 3-hydroxypyridin-4-ones (HPs) are under clinical investigation as iron chelators. Representative HPs have been shown to be potential aluminum chelators by use of in vitro test systems. This study was conducted to determine systemic availabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::567014d8132da6d73739b78ef068d565
https://pubmed.ncbi.nlm.nih.gov/8097694
https://pubmed.ncbi.nlm.nih.gov/8097694
Autor:
R A, Yokel, K M, Dickey
Publikováno v:
Gastroenterology. 100(5 Pt 1)
A method producing persistent gastric ulcers in the rhesus monkey by combined mucosal injury and gamma-irradiation was modified and evaluated in the rabbit. gamma-Irradiation (800-1000 cGy) immediately after removal of 2-mm-diameter sections of antra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9193b6959f0b2d969dcb285cf0dcbcf0
https://pubmed.ncbi.nlm.nih.gov/2013369
https://pubmed.ncbi.nlm.nih.gov/2013369
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 257(1)
Representative amino acids, carboxylic acids, a ketone, hydroxamic acids, 3-hydroxypyridinones and a linear catecholcarboxyamide were tested in vitro to estimate their aluminum (Al) chelation potential. Their ability to solubilize Al from insoluble A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16b1c0245d2ee6c319980ee16ed8b19c
https://pubmed.ncbi.nlm.nih.gov/2019981
https://pubmed.ncbi.nlm.nih.gov/2019981