Zobrazeno 1 - 7
of 7
pro vyhledávání: '"R A, Winegar"'
Autor:
Scott P, Henry, D K, Monteith, J E, Matson, B H, Mathison, K S, Loveday, R A, Winegar, P S, Lee, E S, Riccio, J P, Bakke, A A, Levin
Publikováno v:
Mutagenesis. 17(3)
ISIS 2302, a phosphorothioate oligodeoxynucleotide with antisense activity against human ICAM-1 mRNA, was evaluated in a battery of tests to assess genotoxic potential. There was no evidence of genotoxicity in three in vitro studies performed: (i) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695ede935cacf398a51e64c1289857b2
https://pubmed.ncbi.nlm.nih.gov/11971990
https://pubmed.ncbi.nlm.nih.gov/11971990
Intraperitoneal or intravenous infection of mice with Francisella tularensis LVS is lethal, with an intraperitoneal 50% lethal dose (LD50) approaching a single bacterium. Intradermal (i.d.) LVS infection has a much higher LD50, about 10(6) bacteria i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d4cf1e0a76417da485191802a2f180c
https://europepmc.org/articles/PMC174220/
https://europepmc.org/articles/PMC174220/
Publikováno v:
Cancer research. 52(18)
Radon is a ubiquitous inhaled human carcinogen that is thought to be the largest single natural source of human exposure to radiation. We report that a freely replicating episome in human cells exposed to radon gas underwent mutagenic changes, a high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71cf356fd95d698afecebcbd51a48a03
https://pubmed.ncbi.nlm.nih.gov/1516071
https://pubmed.ncbi.nlm.nih.gov/1516071
Publikováno v:
Radiation research. 128(2)
Restriction enzymes can be electroporated into mammalian cells, and the induced DNA double-strand breaks can lead to aberrations in metaphase chromosomes. Chinese hamster ovary cells were electroporated with PstI, which generates 3' cohesive-end brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ee300e076e2d20dd4f5bdd94bd3b07b
https://pubmed.ncbi.nlm.nih.gov/1658845
https://pubmed.ncbi.nlm.nih.gov/1658845
Publikováno v:
Radiation research. 127(1)
Once electroporated into the nucleus of eukaryotic cells, restriction enzymes will bind at specific DNA sequences and cleave DNA to make double-strand breaks. These induced breaks can lead to chromosome aberrations and consequently offer one approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2aca21e69be63df714de37e57617b79
https://pubmed.ncbi.nlm.nih.gov/1648753
https://pubmed.ncbi.nlm.nih.gov/1648753
Publikováno v:
Radiation research. 125(1)
The electroporation of restriction enzymes into mammalian cells results in DNA double-strand breaks that can lead to chromosome aberrations. Four chemicals known to interfere with cellular responses to DNA damage were investigated for their effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b51a652a21ab0af5e61a8d386af6be15
https://pubmed.ncbi.nlm.nih.gov/1898780
https://pubmed.ncbi.nlm.nih.gov/1898780
Publikováno v:
Progress in clinical and biological research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f99a49c5aded525c8f4e8f5b51861e3
https://pubmed.ncbi.nlm.nih.gov/2168049
https://pubmed.ncbi.nlm.nih.gov/2168049