Symptom-based clusters in patients with advanced chronic organ failure identify different trajectories of symptom variations

Autor: Els R. N. Verstraeten, Raffaele Antonelli Incalzi, Jos M. G. A. Schols, Emiel F.M. Wouters, Panaiotis Finamore, Martijn A. Spruit, Daisy J.A. Janssen

Publikováno v: Aging Clinical and Experimental Research, 33(2), 419-428. Springer, Cham

Background Healthcare needs are complex and heterogeneous in advanced chronic organ failure. However, based on symptom clusters, groups of patients with similar quality of life, care dependency and life-sustaining treatment preferences can be identif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1527b4cff0f5fc2c2cd2394e9e8cfe7d
https://cris.maastrichtuniversity.nl/en/publications/d4ea4558-c517-41d0-853a-e24d67e642fd

Symptom-based clusters in patients with advanced chronic organ failure identify different trajectories of symptom variations

Autor: Panaiotis, Finamore, Daisy J A, Janssen, Jos M G A, Schols, Els R N, Verstraeten, Raffaele, Antonelli Incalzi, Emiel F M, Wouters, Martijn A, Spruit

Publikováno v: Aging clinical and experimental research. 33(2)

Healthcare needs are complex and heterogeneous in advanced chronic organ failure. However, based on symptom clusters, groups of patients with similar quality of life, care dependency and life-sustaining treatment preferences can be identified.To eval

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62c41d228dc4867fd4638552d8930da7
https://pubmed.ncbi.nlm.nih.gov/32951187

Cytoplasmic localization of PML particles in laminopathies

Autor: Frederik Houben, Ingrid P.C. Krapels, M. Coorens, Valerie L. R. M. Verstraeten, Frans C. S. Ramaekers, Carlo Marcelis, G. J. J. Kierkels, W. De Vos, Jos L. V. Broers, Miriam A.F. Kamps, A. van den Wijngaard

Publikováno v: Histochemistry and Cell Biology, 139(1), 119-134. Springer Verlag
Histochemistry and Cell Biology, 139, 119-34
Histochemistry and Cell Biology, 139, 1, pp. 119-34

Item does not contain fulltext There is growing evidence that laminopathies, diseases associated with mutations in the LMNA gene, are caused by a combination of mechanical and gene regulatory distortions. Strikingly, there is a large variability in d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8b0aa3ad705565fada2c340dcdc985
https://doi.org/10.1007/s00418-012-1005-5

Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect

Autor: Lana A. Peckham, Jan Lammerding, Brian C. Capell, Elizabeth G. Nabel, Michelle Olive, Stephen G. Young, Loren G. Fong, Francis S. Collins, Valerie L. R. M. Verstraeten

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 108(12), 4997-5002. National Academy of Sciences

Despite the success of protein farnesyltransferase inhibitors (FTIs) in the treatment of certain malignancies, their mode of action is incompletely understood. Dissecting the molecular pathways affected by FTIs is important, particularly because this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e93e53962ed3ba403a38d0c13f677f
https://doi.org/10.1073/pnas.1019532108

Another Broken Heart

Autor: Jan Lammerding, Valerie L. R. M. Verstraeten

Publikováno v: Circulation Research. 106:234-237

See related articles, pages 346–353 More than one-third of cases of dilated cardiomyopathy (DCM) are caused by inherited mutations, with 5% to 10% of these mutations being linked to the LMNA gene encoding the nuclear envelope proteins lamin A and C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::039485a7d5f51cd3db6ca7205fd7317f
https://doi.org/10.1161/circresaha.109.212001