Zobrazeno 1 - 10
of 71
pro vyhledávání: '"R A, Rifkind"'
Publikováno v:
Molecular and Cellular Biology. 10:3535-3540
Hexamethylene bisacetamide (HMBA) is a potent inducer of differentiation of murine erythroleukemia cells (MELC). Commitment, the irreversible initiation of the program of terminal-cell differentiation, is first detected in HMBA-sensitive DS19-SC9 MEL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dda1a772d5f8e9d833c058656ad6c5a
https://doi.org/10.1128/mcb.10.7.3535
https://doi.org/10.1128/mcb.10.7.3535
Autor:
L Z, He, T, Tolentino, P, Grayson, S, Zhong, R P, Warrell, R A, Rifkind, P A, Marks, V M, Richon, P P, Pandolfi
Publikováno v:
The Journal of clinical investigation. 108(9)
Acute promyelocytic leukemia (APL) is associated with chromosomal translocations, invariably involving the retinoic acid receptor alpha (RAR alpha) gene fused to one of several distinct loci, including the PML or PLZF genes, involved in t(15;17) or t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91b4bc8a13039d597663a3926eeebc22
https://pubmed.ncbi.nlm.nih.gov/11696570
https://pubmed.ncbi.nlm.nih.gov/11696570
Autor:
D C, Coffey, M C, Kutko, R D, Glick, L M, Butler, G, Heller, R A, Rifkind, P A, Marks, V M, Richon, M P, La Quaglia
Publikováno v:
Cancer research. 61(9)
Histone deacetylase inhibitors (HDACIs) inhibit the growth of a variety of transformed cells in culture. We demonstrated previously that the hybrid-polar HDACI m-carboxycinnamic acid bis-hydroxamide (CBHA) induces apoptosis of human neuroblastoma in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::711b386c598491c8a0f199f8775a5b98
https://pubmed.ncbi.nlm.nih.gov/11325825
https://pubmed.ncbi.nlm.nih.gov/11325825
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8b464baaaef9db4c85765d42f3fbc844
https://pubmed.ncbi.nlm.nih.gov/11309319
https://pubmed.ncbi.nlm.nih.gov/11309319
Autor:
L M, Butler, Y, Webb, D B, Agus, B, Higgins, T R, Tolentino, M C, Kutko, M P, LaQuaglia, M, Drobnjak, C, Cordon-Cardo, H I, Scher, R, Breslow, V M, Richon, R A, Rifkind, P A, Marks
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(4)
We have synthesized a series of hybrid polar compounds that induce differentiation and/or apoptosis of various transformed cells. These agents are also potent inhibitors of histone deacetylases (HDACs). Pyroxamide (suberoyl-3-aminopyridineamide hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98d5ab367e894db7af585301141501c2
https://pubmed.ncbi.nlm.nih.gov/11309347
https://pubmed.ncbi.nlm.nih.gov/11309347
Autor:
L M, Butler, D B, Agus, H I, Scher, B, Higgins, A, Rose, C, Cordon-Cardo, H T, Thaler, R A, Rifkind, P A, Marks, V M, Richon
Publikováno v:
Cancer research. 60(18)
Suberoylanilide hydroxamic acid (SAHA) is the prototype of a family of hybrid polar compounds that induce growth arrest in transformed cells and show promise for the treatment of cancer. SAHA induces differentiation and/or apoptosis in certain transf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::35393e5749083d4685265794e45d8e72
https://pubmed.ncbi.nlm.nih.gov/11016644
https://pubmed.ncbi.nlm.nih.gov/11016644
Publikováno v:
Anticancer research. 19(6B)
Hybrid Polar Cytodifferentiation (HPC) agents represent a novel class of anticancer compounds which act by inducing terminal differentiation and/or apoptosis rather than by cytotoxic action. Among these are HPC agents such as hexamethylenebisacetamid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b75e15e5b75fd6589ec8077538bbe893
https://pubmed.ncbi.nlm.nih.gov/10697502
https://pubmed.ncbi.nlm.nih.gov/10697502
Autor:
R D, Glick, S L, Swendeman, D C, Coffey, R A, Rifkind, P A, Marks, V M, Richon, M P, La Quaglia
Publikováno v:
Cancer research. 59(17)
Inhibitors of histone deacetylase (HDAC) have been shown to have both apoptotic and differentiating effects on various tumor cells. M-carboxycinnamic acid bishydroxamide (CBHA) is a recently developed hybrid polar compound structurally related to hex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::968b8a0c461868a5359fcac6ca9d8cc9
https://pubmed.ncbi.nlm.nih.gov/10485488
https://pubmed.ncbi.nlm.nih.gov/10485488
Publikováno v:
Cancer research. 57(13)
Many transformed cells have been found to lose the capacity to proliferate and undergo differentiation following exposure to hybrid polar agents. This study investigates the mechanism by which hexamethylene bisacetamide (HMBA) suppresses the prolifer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16a27133e27ca7dc0396d6f177b73b47
https://pubmed.ncbi.nlm.nih.gov/9205091
https://pubmed.ncbi.nlm.nih.gov/9205091
Publikováno v:
International journal of hematology. 63(1)
Considerable progress has been made toward elucidating the pathway of induction of terminal differentiation of transformed cells by hybrid polar compounds such as hexamethylene bisacetamide (HMBA). HMBA alters factors controlling G1-to-S phase transi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5c560a1820e0098d00a76462d28e4ea
https://pubmed.ncbi.nlm.nih.gov/8713572
https://pubmed.ncbi.nlm.nih.gov/8713572