Zobrazeno 1 - 10
of 10
pro vyhledávání: '"R A, Okerholm"'
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 21(3)
The antihistaminic drug terfenadine, alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1- piperidinebutanol (Seldane), is of interest because of its lack of sedative properties. Major routes of metabolism include oxidative N-dealkylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::56d6834adeef7c59caff7aa0c5415bed
https://pubmed.ncbi.nlm.nih.gov/8100494
https://pubmed.ncbi.nlm.nih.gov/8100494
Publikováno v:
European Journal of Clinical Pharmacology. 13:35-39
A competitive protein binding assay for norethindrone was developed to measure plasma levels in human subjects. The plasma levels were considerably higher in women than in men, especially at low dose levels. The plasma levels were directly related to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62e4106d24a4e2b3999b715951b24cb
https://doi.org/10.1007/bf00606680
https://doi.org/10.1007/bf00606680
Publikováno v:
Proceedings of the Royal Society of Medicine. 69:11-14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d6bc7f47af63d9c11dae28ea3743858
https://doi.org/10.1177/00359157760690s204
https://doi.org/10.1177/00359157760690s204
Publikováno v:
Research communications in chemical pathology and pharmacology. 10(2)
The metabolic disposition.of zolazepam, a pyrazolodiazepinone, was studied in male and female Spartan rats, Beagle dogs and Rhesus monkeys. Six principal urinary metabolites were characterized by gas chromatography and combined gas chromatography-mas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::068e82a414eb8d7a02c0f6338c90e690
https://pubmed.ncbi.nlm.nih.gov/808840
https://pubmed.ncbi.nlm.nih.gov/808840
Publikováno v:
Research communications in chemical pathology and pharmacology. 9(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c2f92b5401ff0f249407efee82cdc05f
https://pubmed.ncbi.nlm.nih.gov/4445562
https://pubmed.ncbi.nlm.nih.gov/4445562
Autor:
K Y, Chan, R A, Okerholm
Publikováno v:
Journal of chromatography. 274
A sensitive, specific and reliable assay utilizing a combined gas chromatography--mass spectrometry--selected ion monitoring technique is described for the quantitative determination of melperone, a neuroleptic agent, in human plasma. Using a 2-ml pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::21693a4f2d51c1f9c3f745537752c7ea
https://pubmed.ncbi.nlm.nih.gov/6135699
https://pubmed.ncbi.nlm.nih.gov/6135699
Publikováno v:
Arzneimittel-Forschung. 32(9a)
Comparison of plasma level data obtained from a dose-response study to that of a 14C material balance study indicates that 99.48% of the alpha-[4-(1,1-dimethylethyl)phenyl] 4-(hydroxydiphenylmethyl)-1-piperidinebutanol (terfenadine, RMI 9918, Triluda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d2ee23dc5e11ae8f7809942772c9a3ff
https://pubmed.ncbi.nlm.nih.gov/6817765
https://pubmed.ncbi.nlm.nih.gov/6817765
Publikováno v:
Arzneimittel-Forschung. 32(9a)
Alpha-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1- piperidinebutanol (terfenadine, RMI 9918, Triludan, Teldane, resp.), a clinically effective antihistamine, with little or no central nervous system effects, was investigated in order to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33f97a9293cd516866acb0d8858d2b6e
https://pubmed.ncbi.nlm.nih.gov/6817764
https://pubmed.ncbi.nlm.nih.gov/6817764
Publikováno v:
Research communications in chemical pathology and pharmacology. 4(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c1e6d67e32f439f1e309db57d5bde0ec
https://pubmed.ncbi.nlm.nih.gov/4671868
https://pubmed.ncbi.nlm.nih.gov/4671868
Publikováno v:
Journal of Steroid Biochemistry. 5:374
A competitive protein binding method has been developed for the quantitative analysis of norethindrone (NE) in plasma and urine utilizaing the progesterone binding globulin of pregnant guinea pig serum. The method involves dilution of the sample with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdd1c2c275fe96d057f54f340653846a
https://doi.org/10.1016/0022-4731(74)90474-9
https://doi.org/10.1016/0022-4731(74)90474-9