Zobrazeno 1 - 10
of 23
pro vyhledávání: '"R A, Naseem"'
Autor:
S. Manjubhashini, Sherva Cooray, Kiran Purandare, Fola Esan, Ignatius Gunaratna, Benjamin Ian Perry, Ashok Roy, Regi Alexander, Hang Fai Kwok, Verity Chester, Sudeep Hoare, Anusha Wijeratne, Jayan Mendis, R. A. Naseem, John Devapriam, M. Dasari
Publikováno v:
Journal of Intellectual Disability Research. 62:140-149
Background Problem behaviours (PBs) are a common cause for clinician contact in people with disorders of intellectual development and may be a common cause for the prescription of psychotropic medication. We aimed to use a large, multinational sample
Autor:
B I, Perry, S E, Cooray, J, Mendis, K, Purandare, A, Wijeratne, S, Manjubhashini, M, Dasari, F, Esan, I, Gunaratna, R A, Naseem, S, Hoare, V, Chester, A, Roy, J, Devapriam, R, Alexander, H F, Kwok
Publikováno v:
Journal of intellectual disability research : JIDR. 62(2)
Problem behaviours (PBs) are a common cause for clinician contact in people with disorders of intellectual development and may be a common cause for the prescription of psychotropic medication. We aimed to use a large, multinational sample to define
Autor:
Joan S. Reisch, James deLemos, Joseph A. Hill, Vassilis Dimas, R. Haris Naseem, Ryan S. Williams
Publikováno v:
Clinical Cardiology. 34:415-419
Background: Several studies have shown that the modulation of fibrotic scar in cardiac diseases has beneficial effects on cardiac arrhythmias. In addition, recent reports suggest a potential role of mineralocorticoid receptor upregulation in atrial f
Autor:
Colby Ayers, R. Haris Naseem, James D Daniels, Joseph A. Hill, Vassilis Dimas, Jose A. Joglar
Publikováno v:
Pacing and Clinical Electrophysiology. 34:309-314
Introduction: Multiple pharmacological therapies currently in prevalent clinical use for cardiac diseases have antifibrotic properties. Spironolactone, a potent antifibrotic agent, is currently used for advanced heart failure. Therapies such as HMG-C
Autor:
Joseph A. Hill, Jeffrey E. Thatcher, Eva van Rooij, R. Haris Naseem, William S. Marshall, Eric N. Olson, Lillian B. Sutherland, J. Michael DiMaio
Publikováno v:
Proceedings of the National Academy of Sciences. 105:13027-13032
Acute myocardial infarction (MI) due to coronary artery occlusion is accompanied by a pathological remodeling response that includes hypertrophic cardiac growth and fibrosis, which impair cardiac contractility. Previously, we showed that cardiac hype
Publikováno v:
Drug Discovery Today: Disease Models. 4:197-206
The prevalence of heart failure is increasing rapidly worldwide, and yet effective treatments remain elusive. Pathological remodeling of the ventricle – and associated hypertrophic growth, fibrotic change, cavity dilatation and electrophysiological
Autor:
Young H Lee, Byung Hyun Park, Jean E. Schaffer, R. Haris Naseem, Roger H Unger, James A. Richardson, Daniel J. Garry
Publikováno v:
Biochemical and Biophysical Research Communications. 344:446-452
Alpha-lipoic acid (alpha-LA) mimics the hypothalamic actions of leptin on food intake, energy expenditure, and activation of AMP-activated protein kinase (AMPK). To determine if, like leptin, alpha-LA protects against cardiac lipotoxicity, alpha-LA w
Publikováno v:
Circulation. 112:2293-2300
Background— In heart failure, exercise elicits excessive increases in mean arterial pressure (MAP) and heart rate (HR). Using a novel rat model, we previously demonstrated that this exaggerated cardiovascular responsiveness is mediated by an overac
Autor:
Wade Hedegard, Kathryn Sutter, Jennifer Lessard, Stephen A. Katz, R. Harris Naseem, Timothy D. Henry
Publikováno v:
Basic Research in Cardiology. 100:139-146
Plasma renin activity (PRA) is often found to increase after myocardial infarction (MI). Elevated PRA may contribute to increased myocardial angiotensin II that is responsible for maladaptive remodeling of the myocardium after MI. We hypothesized tha
Autor:
James A. Richardson, R. Haris Naseem, Roger H Unger, Daniel J. Garry, Laurence Duplomb, Jean E. Schaffer, Young H Lee, Byung-Hyun Park
Publikováno v:
Proceedings of the National Academy of Sciences. 101:13624-13629
The physiologic function of the progressive hyperleptinemia of diet-induced obesity is unknown. However, that lipotoxicity in nonadipose tissues of congenitally unleptinized obese rodents is far greater than in hyperleptinemic diet-induced obesity ro