Zobrazeno 1 - 9
of 9
pro vyhledávání: '"R A, Morrisett"'
Autor:
R, Renteria, Z M, Jeanes, R A, Mangieri, E Y, Maier, D M, Kircher, T R, Buske, R A, Morrisett
Publikováno v:
International review of neurobiology. 126
The nucleus accumbens (NAc) is a central component of the mesocorticolimbic reward system. Increasing evidence strongly implicates long-term synaptic neuroadaptations in glutamatergic excitatory activity of the NAc shell and/or core medium spiny neur
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 287(1)
Synaptic mechanisms underlying hyperexcitability due to withdrawal from chronic ethanol exposure were investigated in a hippocampal explant model system using electrophysiological techniques. Whole-cell voltage clamp recordings from CA1 pyramidal cel
Publikováno v:
Alcoholism, clinical and experimental research. 22(1)
Assessment of long-term alterations in neural function and phenotype has usually involved culture techniques that utilize dissociated preparations. Recently, we have approached such topics in alcohol research by using brain slice cultures, also known
Publikováno v:
Molecular pharmacology. 48(4)
Ethanol inhibits N-methyl-D-aspartate (NMDA) receptor-mediated responses at pharmacologically relevant concentrations, suggesting that inhibition of NMDA receptors may underlie some of the actions of ethanol in the central nervous system. We examined
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 274(2)
Neuropeptide Y (NPY) is a widely distributed peptide with varied activities including inhibition of [3H]NE secretion from chromaffin cells. In the present study, we investigated the mechanism through which NPY and NPY fragments inhibit nicotinic rece
Autor:
R A, Morrisett
Publikováno v:
Neuroscience letters. 167(1-2)
The contribution of NMDA receptors to neuronal hyperexcitability following in vitro ethanol withdrawal was examined using afterdischarges (ADs) in rat dentate gyrus as a model system. ADs were evoked by high frequency stimuli and blocked by N-methyl-
Publikováno v:
Neuropharmacology. 30(11)
The role of magnesium ions in the inhibitory effect of ethanol on NMDA receptor-mediated population synaptic potentials (pEPSPs) in area CA1 of the hippocampus of the adult rat, was studied. The excitatory amino acid (non-NMDA) receptor antagonist, D
Publikováno v:
Brain research. Developmental brain research. 56(2)
This study describes the measurement of N-methyl-D-aspartate (NMDA)-mediated excitatory postsynaptic potentials (EPSPs) of the CA1 subregion of transverse hippocampal slices from immature and adult rats. Our methods permit extracellular measurement o
Publikováno v:
Advances in experimental medicine and biology. 268
Our studies suggest that treatments, such as kindling and exposure to ethanol in utero, which produce irreversible pathological changes in brain function also selectively alter neuronal responses to NMDA. We have identified increases in agonist poten