Výsledky vyhledávání - "R A, Kotel'nikova"

Hybrid Materials Based on Dimethylbiguanide (Metformin) and Copolymer of N-Vinylpyrrolidone with Triethylene Glycol Dimethacrylate

Autor: Gennady V. Shilov, Nina S. Emel’yanova, A. A. Grishchuk, Yu. V. Soldatova, V. M. Ignat’ev, N. V. Fadeeva, I. I. Faingold, R. A. Kotel’nikova, Svetlana V. Kurmaz

Publikováno v: Polymer Science, Series A. 63:106-116

Using metformin, a broad spectrum drug, and the branched amphiphilic copolymer of N-vinylpyrrolidone and triethylene glycol dimethacrylate with a molar ratio of comonomers of 80 : 20 and a weight average molecular weight of 1.96 × 105 hybrid materia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7257cb97b805e3250d562951cb2d21b0
https://doi.org/10.1134/s0965545x2102005x

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Self-Diffusion of Fullerene С60 Derivatives in Aqueous Solutions and Suspensions of Erythrocytes According to Pulsed Field Gradient NMR Data

Autor: E. A. Dolgikh, Alexander V. Zhilenkov, R. A. Kotel’nikova, Yu. V. Soldatova, Vitaly I. Volkov, Irina A. Avilova, P. A. Troshin, Olga A. Kraevaya

Publikováno v: Russian Journal of Physical Chemistry A. 95:285-291

Determination of the mechanism of substance penetration in biological cells is one of the fundamental problems of metabolism. Interest in the water-soluble derivatives of fullerene C60 is dictated by their high biological activity (targeted drug deli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73328dcbb71368248ce409e914537520
https://doi.org/10.1134/s0036024421020047

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Water-soluble fullerene derivatives: the inhibition effect on polyol pathway enzymes and antidiabetic potential on high-fat diet/low-dose streptozotocin-induced diabetes in rats

Autor: Pavel A. Troshin, R. A. Kotel’nikova, Yuliya V. Soldatova, Olga A. Kraevaya, Alexander S. Peregudov, Alexander V. Zhilenkov, David A. Areshidze, Daria A. Poletaeva, I. I. Faingold

Publikováno v: Journal of Nanoparticle Research. 23

Water-soluble pentaamino acid fullerene (C60) derivatives (PFD) are promising nanomaterials with a wide range of biomedical applications. The present study has shown that PFD-7 competitively inhibits aldose reductase and sorbitol dehydrogenase, enzym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::472a90f3369ccc689de4c1e31aeb7f54
https://doi.org/10.1007/s11051-021-05313-2

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Effects of albumin-bound nitrosyl iron complex with thiosulfate ligands on lipid peroxidation and activities of mitochondrial enzymes in vitro

Autor: Yu. V. Soldatova, Natalia A. Sanina, D. A. Poletaeva, A. V. Smolina, R. A. Kotel’nikova, I. I. Faingold, A.V. Kulikov, O. V. Pokidova

Publikováno v: Nitric oxide : biology and chemistry. 117

Nitric oxide (NO) mediates diverse physiological processes in living organisms. Small molecular NO donors usually lack stability and have a short half‐life in human tissues, limiting the therapeutic application. The anionic tetranitrosyl iron compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e410803f0db76b75bd61b905cc9176f1
https://pubmed.ncbi.nlm.nih.gov/34678508

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Potassium Salt of Fullerenylpenta-N-Dihydroxytyrosine Effects on Type 2 Diabetes Mellitus Therapeutic Targets

Autor: M. A. Kozlova, I. I. Faingold, Alexander V. Zhilenkov, D. A. Areshidze, R. A. Kotel’nikova, P. A. Troshin, S. M. Aldoshin, Yu. V. Soldatova

Publikováno v: Doklady Biochemistry and Biophysics. 488:320-323

It was shown for the first time that pentaamino acid derivative of fullerene C60 (potassium salt of fullerenylpenta-N-dihydroxytyrosine) affects three targets of type 2 diabetes mellitus. It competitively inhibits the enzymes aldose reductase and sor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f185098eb601ff7bc1c759e02224aa
https://doi.org/10.1134/s1607672919050089

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New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer’s Disease Treatment

Autor: Igor V. Serkov, Nadezhda V. Kovaleva, Eugene V. Radchenko, Darya A Poletaeva, Galina F. Makhaeva, Rudy J. Richardson, I. I. Faingold, Elena V. Rudakova, R. A. Kotel’nikova, Sofya V. Lushchekina, A. K. Ustinov, N. P. Boltneva, Alexey N. Proshin, Yuliya V. Soldatova, Vladimir A. Palyulin

Publikováno v: Molecules, Vol 25, Iss 5891, p 5891 (2020)
Molecules
Volume 25
Issue 24

New hybrids of 4-amino-2,3-polymethylenequinoline with different sizes of the aliphatic ring linked to butylated hydroxytoluene (BHT) by enaminoalkyl (7) or aminoalkyl (8) spacers were synthesized as potential multifunctional agents for Alzheimer&rsq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d7355e822d741559dfb6562eb738ea
https://www.mdpi.com/1420-3049/25/24/5891

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Membranotropic properties of fullerene-containing amphiphilic (co)polymers of N-vinylpyrrolidone

Autor: I. I. Faingold, Yu. V. Soldatova, V. S. Romanova, A. D. Lozhkin, Svetlana V. Kurmaz, V. N. Shtol’ko, R. A. Kotel’nikova, A. V. Smolina, N. А. Obraztsova

Publikováno v: Russian Chemical Bulletin. 67:800-805

The effect of fullerene-containing amphiphilic (co)polymers of N-vinylpyrrolidone (C60/PVP) differed in composition and topology of the polymer chains on the membrane structure of phosphatidylcholine liposomes was studied. Using the method of fluores

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2109f8e676f41fff6e9738bededb0db8
https://doi.org/10.1007/s11172-018-2140-5

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Interaction of water-soluble pentaamino acid fullerene derivatives with membranes of phosphatidylcholine liposomes

Autor: Yu. V. Soldatova, R. A. Kotel’nikova, Alexander I. Kotelnikov, I. I. Faingold, P. A. Troshin, Alexander V. Zhilenkov, A. V. Smolina

Publikováno v: Russian Chemical Bulletin. 67:366-370

Regularities of interaction of water-soluble pentaamino acid derivatives of fullerenes (WPDFs) with the lipid bilayer of phosphatidylcholine liposomes were studied using the fluorescent probe method. The studied WPDFs act as quenchers of fluorescence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5ffce5642135d83a74af0a9598eca2f
https://doi.org/10.1007/s11172-018-2082-y

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Influence of hemoglobin and albumin on the NO donation effect of tetranitrosyl iron complex with thiosulfate

Autor: Sergey M. Aldoshin, R. A. Kotel’nikova, O. V. Pokidova, Tatiana N. Rudneva, Bogdan A. Tretyakov, Alexander I. Kotelnikov

Publikováno v: Nitric oxide : biology and chemistry. 94

The effects of deoxyhemoglobin (Hb) and albumin on the NO-donor activity of the anionic tetranitrosyl iron complex with thiosulfate ligands (1) were studied for the first time. It was shown that Hb significantly stabilizes complex 1; in its presence,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cce9842a4375e691547d45d823f1747
https://pubmed.ncbi.nlm.nih.gov/31678147

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Antioxidant Activity of Tetranitrosyl Iron Complex with Thiosulfate Ligands and Its Effect on Catalytic Activity of Mitochondrial Enzymes In vitro

Autor: I. I. Faingold, Sergey M. Aldoshin, A. P. Sadkov, R. A. Kotel’nikova, Natalia A. Sanina, D. A. Poletaeva, A. V. Smolina, Yu. V. Soldatova, O. V. Pokidova

Publikováno v: Doklady. Biochemistry and biophysics. 488(1)

The antioxidant and antiradical properties of the tetra nitrosyl iron complex with thiosulfate ligands (TNIC) were studied in vitro in mouse brain homogenates. It was found for the first time that TNIC is an effective antioxidant. The effect of TNIC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61561791351dca2aba7ccd04292f663c
https://pubmed.ncbi.nlm.nih.gov/31768856

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