Zobrazeno 1 - 10
of 42
pro vyhledávání: '"R A, Goodlad"'
Publikováno v:
Gut. 42:799-806
Background—Fermentable dietary fibre has many effects on the gastrointestinal tract. One is to alter epithelial crypt cell proliferation, especially in the colon. A discrepancy between epithelial cell production rates and intestinal weights has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5acdb89ecda1990c571f24c79df59e3
https://doi.org/10.1136/gut.42.6.799
https://doi.org/10.1136/gut.42.6.799
Autor:
Terry G. Unterman, Aleksandra Jovanovic Poole, R A Goodlad, Steven M. Swanson, Angela L. Tyner, R. Brooks Robey, Robert E. Carroll
Objectives To evaluate the role of GH in colon carcinogenesis, we examined the formation of aberrant crypt foci (ACFs) and tumor development in wild type (WT) and GH-deficient, spontaneous dwarf rats (SDRs) exposed to the carcinogen azoxymethane (AOM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1008968a268ca4b70dbca3c8809421
https://europepmc.org/articles/PMC3005240/
https://europepmc.org/articles/PMC3005240/
Autor:
S L, Preston, S J, Leedham, D, Oukrif, M, Deheregoda, R A, Goodlad, R, Poulsom, M R, Alison, N A, Wright, M, Novelli
Publikováno v:
The Journal of pathology. 214(3)
The morphological changes associated with the adenoma-carcinoma sequence are well documented in the colorectum. Small intestinal carcinogenesis is thought to progress through a similar adenoma-to-carcinoma pathway, but there is a relative dearth of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3661d71af19f795a356a1198b947c2a7
https://pubmed.ncbi.nlm.nih.gov/18085615
https://pubmed.ncbi.nlm.nih.gov/18085615
Autor:
Angela, Kelsall, A J, FitzGerald, C V, Howard, R C, Evans, R, Singh, J M, Rhodes, R A, Goodlad
Publikováno v:
International journal of experimental pathology. 83(4)
Lectins are proteins or glycoproteins of nonimmune origin, which bind specifically to carbohydrate structures. They are widespread in the human diet, and many are resistant to digestion. High doses of lectins have been shown to stimulate intestinal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c227a7b3c73565438581979b2b1d53fc
https://pubmed.ncbi.nlm.nih.gov/12485464
https://pubmed.ncbi.nlm.nih.gov/12485464
Publikováno v:
Alimentary pharmacologytherapeutics. 16(3)
Elemental diets cause intestinal atrophy and reduced intestinal integrity, which can lead to significant increases in intestinal permeability and bacterial translocation. Recently, several lectins have been shown to have trophic effects on the intest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb4114d5daaa4d1dd547e053e140a1df
https://pubmed.ncbi.nlm.nih.gov/11876719
https://pubmed.ncbi.nlm.nih.gov/11876719
Publikováno v:
Alimentary pharmacologytherapeutics. 15(10)
Many experiments have indicated that the gut glucagons (enteroglucagons) are associated with cell proliferation in the small intestine. However, recent studies have failed to show trophic effects of glicentin (enteroglucagon) on the intestine.To exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aaa03c90008527e3784defe960d5cbdb
https://pubmed.ncbi.nlm.nih.gov/11564010
https://pubmed.ncbi.nlm.nih.gov/11564010
Publikováno v:
Alimentary pharmacologytherapeutics. 15(7)
Concanavalin-A, the lectin present in Jack beans, binds to mannose- and glucose-containing residues and can interact with the epidermal growth factor receptor and moderate cell proliferation in vitro.To compare the actions of concanavalin-A and epide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::04cdce78e4f7b793e65446285d67ea53
https://pubmed.ncbi.nlm.nih.gov/11421885
https://pubmed.ncbi.nlm.nih.gov/11421885
Publikováno v:
Digestive diseases and sciences. 46(6)
Proglucagon-derived peptides have been implicated in the control of intestinal mucosal cell division. To investigate the actions of these peptides on intestinal cell proliferation, different doses of enteroglucagon, oxyntomodulin, glucagon-like pepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::523fc7e50ab46db6d8f0d305af14f81c
https://pubmed.ncbi.nlm.nih.gov/11414302
https://pubmed.ncbi.nlm.nih.gov/11414302
Publikováno v:
Virchows Archiv B Cell Pathology Including Molecular Pathology. 61:415-417
Colonic epithelial proliferation was investigated in three groups of rats, aged 3, 60 and 121 weeks. As reported in previous work, the crypts were markedly longer in the young rats, and the number of labelled cells per crypt was significantly greater
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7cb0eadb62660fda808851f23ae4d6
https://doi.org/10.1007/bf02890445
https://doi.org/10.1007/bf02890445
Autor:
Christopher E Macdonald, D Calnan, W Johnson, R O Adenekan, Tania Marchbank, David N. Floyd, R A Goodlad, Raymond J. Playford
Publikováno v:
Gut. 44(5)
BACKGROUNDNon-steroidal anti-inflammatory drugs (NSAIDs) are effective for arthritis but cause gastrointestinal injury. Bovine colostrum is a rich source of growth factors and is marketed as a health food supplement.AIMSTo examine whether spray dried
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7492eda78c16f45527bd67678b2208cb
https://pubmed.ncbi.nlm.nih.gov/10205201
https://pubmed.ncbi.nlm.nih.gov/10205201