Zobrazeno 1 - 10
of 188
pro vyhledávání: '"R A, Diez"'
Autor:
Maria Laura Saiz, Laura Lozano-Chamizo, Aida Bernardo Florez, Marzia Marciello, Paula Diaz-Bulnes, Viviana Corte-Iglesias, Cristian Ruiz Bernet, Raul R. Rodrigues-Diez, Cristina Martin-Martin, Mar Rodriguez-Santamaria, Ivan Fernandez-Vega, Ramon M. Rodriguez, Carmen Diaz-Corte, Beatriz Suarez-Alvarez, Marco Filice, Carlos Lopez-Larrea
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116492- (2024)
Targeting epigenetic mechanisms has emerged as a potential therapeutic approach for the treatment of kidney diseases. Specifically, inhibiting the bromodomain and extra-terminal (BET) domain proteins using the small molecule inhibitor JQ1 has shown p
Externí odkaz:
https://doaj.org/article/faef2a249ec44921b88449981de7a8ea
Autor:
Raúl R. Rodrigues-Diez, Antonio Tejera-Muñoz, Macarena Orejudo, Laura Marquez-Exposito, Laura Santos, Sandra Rayego-Mateos, Elena Cantero-Navarro, Lucia Tejedor-Santamaria, Vanessa Marchant, Alberto Ortiz, Jesús Egido, Sergio Mezzano, Rafael Selgas, Juan F. Navarro-González, Jose M. Valdivielso, Carolina Lavoz, Marta Ruiz-Ortega
Publikováno v:
Nefrología, Vol 41, Iss 3, Pp 244-257 (2021)
Resumen: La interleuquina 17A (IL-17A) es una citoquina proinflamatoria producida por células del sistema inmune, sobre todo por los linfocitos Th17 y los linfocitos γδ. En este trabajo, revisamos el papel de IL-17A en la patogenia de la hipertens
Externí odkaz:
https://doaj.org/article/bc4b6400203c47e4a3f975601cac4a51
Autor:
Raúl R. Rodrigues-Diez, Antonio Tejera-Muñoz, Macarena Orejudo, Laura Marquez-Exposito, Laura Santos-Sanchez, Sandra Rayego-Mateos, Elena Cantero-Navarro, Lucia Tejedor-Santamaria, Vanessa Marchant, Alberto Ortiz, Jesús Egido, Sergio Mezzano, Rafael Selgas, Juan F. Navarro-González, Jose M. Valdivielso, Carolina Lavoz, Marta Ruiz-Ortega
Publikováno v:
Nefrología (English Edition), Vol 41, Iss 3, Pp 244-257 (2021)
Interleukin-17A (IL-17A) is a proinflammatory cytokine produced by cells of the immune system, predominantly Th17 and γδ lymphocytes. In this paper, we review the role of IL-17A in the pathogenesis of hypertension and in target organ damage. Precli
Externí odkaz:
https://doaj.org/article/83149afb48cd47049f3cfeb094a5b112
Autor:
Milica Bozic, Maite Caus, Raul R. Rodrigues-Diez, Neus Pedraza, Marta Ruiz-Ortega, Eloi Garí, Pilar Gallel, Maria José Panadés, Ana Martinez, Elvira Fernández, José Manuel Valdivielso
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Renal fibrosis is a deleterious process and a final manifestation of chronic kidney disease. Here, the authors demonstrate a role of alpha-synuclein in the maintenance of the epithelial phenotype of renal proximal tubular epithelial cells and in prot
Externí odkaz:
https://doaj.org/article/1abf8b1a32e645768f299becb7117c14
Autor:
Elena Cantero-Navarro, Sandra Rayego-Mateos, Macarena Orejudo, Lucía Tejedor-Santamaria, Antonio Tejera-Muñoz, Ana Belén Sanz, Laura Marquez-Exposito, Vanessa Marchant, Laura Santos-Sanchez, Jesús Egido, Alberto Ortiz, Teresa Bellon, Raúl R. Rodrigues-Diez, Marta Ruiz-Ortega
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Inflammation is a key characteristic of kidney disease, but this immune response is two-faced. In the acute phase of kidney injury, there is an activation of the immune cells to fight against the insult, contributing to kidney repair and regeneration
Externí odkaz:
https://doaj.org/article/eec648e0a92a47858d82fa4128d29513
Autor:
Laura Marquez-Exposito, Lucia Tejedor-Santamaria, Laura Santos-Sanchez, Floris A. Valentijn, Elena Cantero-Navarro, Sandra Rayego-Mateos, Raul R. Rodrigues-Diez, Antonio Tejera-Muñoz, Vanessa Marchant, Ana B. Sanz, Alberto Ortiz, Roel Goldschmeding, Marta Ruiz-Ortega
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Acute kidney injury (AKI) is more frequent in elderly patients. Mechanisms contributing to AKI (tubular cell death, inflammatory cell infiltration, impaired mitochondrial function, and prolonged cell-cycle arrest) have been linked to cellular senesce
Externí odkaz:
https://doaj.org/article/eb14e45a559945cd9ceb2ba0fcda3ed8
Autor:
Paula Diaz-Bulnes, Maria Laura Saiz, Viviana Corte-Iglesias, Raúl R Rodrigues-Diez, Aida Bernardo Florez, Cristian Ruiz Bernet, Cristina Martin Martin, Marta Ruiz-Ortega, Beatriz Suarez-Alvarez, Carlos López-Larrea
Publikováno v:
Antioxidants, Vol 11, Iss 7, p 1355 (2022)
Loss of protein homeostasis (proteostasis) in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR), restoring correct protein folding. Sustained ER stress exacerbates activation of the major UPR branches (IRE1α/XBP1, PERK/ATF
Externí odkaz:
https://doaj.org/article/607d22f0cf2b41fcb61e583db649dfcd
Autor:
Sandra Rayego-Mateos, Raul R Rodrigues-Diez, Beatriz Fernandez-Fernandez, Carmen Mora-Fernández, Vanessa Marchant, Javier Donate-Correa, Juan F. Navarro-González, Alberto Ortiz, Marta Ruiz-Ortega
Publikováno v:
Kidney International. 103:282-296
Diabetic kidney disease (DKD) is one of the fastest growing causes of chronic kidney disease and associated morbidity and mortality. Preclinical research has demonstrated the involvement of inflammation in its pathogenesis and in the progression of k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cbc72017fdfa3ca01385344cdbf1f7
https://doi.org/10.1016/j.kint.2022.10.030
https://doi.org/10.1016/j.kint.2022.10.030
Autor:
Laura Marquez-Exposito, Lucia Tejedor-Santamaria, Floris A. Valentijn, Antonio Tejera-Muñoz, Sandra Rayego-Mateos, Vanessa Marchant, Raul R. Rodrigues-Diez, Irene Rubio-Soto, Sebastiaan N. Knoppert, Alberto Ortiz, Adrian M. Ramos, Roel Goldschmeding, Marta Ruiz-Ortega
Publikováno v:
Antioxidants, Vol 11, Iss 2, p 301 (2022)
Chronic kidney disease (CKD) can be considered as a clinical model for premature aging. However, non-invasive biomarkers to detect early kidney damage and the onset of a senescent phenotype are lacking. Most of the preclinical senescence studies in a
Externí odkaz:
https://doaj.org/article/d002d1286d534b6da2af5e99bd15335e
Autor:
Lucia Tejedor-Santamaria, Jose Luis Morgado-Pascual, Laura Marquez-Exposito, Beatriz Suarez-Alvarez, Raul R. Rodrigues-Diez, Antonio Tejera-Muñoz, Vanessa Marchant, Sergio Mezzano, Carlos Lopez-Larrea, Anna Sola, Gema Maria Fernandez-Juarez, Alberto Ortiz, Sandra Rayego-Mateos, Marta Ruiz-Ortega
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 121 (2022)
Crescentic glomerulonephritis is a devastating autoimmune disease that without early and properly treatment may rapidly progress to end-stage renal disease and death. Current immunosuppressive treatment provides limited efficacy and an important burd
Externí odkaz:
https://doaj.org/article/5f033fe79f654d77a5d276372d885471