Zobrazeno 1 - 10
of 45
pro vyhledávání: '"R A, Deitrich"'
Publikováno v:
British Journal of Pharmacology. 118:378-384
1. The effects of n-alcohols on GABAA and glutamate receptor systems were examined, and in vitro effectiveness was compared with in vivo effects in mice and tadpoles. We expressed GABAA, NMDA, AMPA, or kainate receptors in Xenopus oocytes and examine
Publikováno v:
Annals of the New York Academy of Sciences. 625:551-554
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 299(2)
Evidence indicates that sensitivity to ethanol is a good predictor of the development of alcoholism. Thus, identification of neuronal processes that regulate ethanol sensitivity has been the subject of much recent research. The present studies were d
Publikováno v:
Alcoholism, clinical and experimental research. 25(7)
This study was designed to investigate the relationship between the ethanol-oxidizing capacity of the brain, accumulation of acetaldehyde, and ethanol-induced hypnosis in animals in vivo.Randomly outbred albino rats were treated with ethanol, and the
Publikováno v:
Alcoholism, clinical and experimental research. 25(7)
To clarify the role of brain acetaldehyde in the hypnotic effect of ethanol, we compared the ethanol-oxidizing capacity (rate of acetaldehyde accumulation) and catalase and aldehyde dehydrogenase activity in the brains of animals genetically selected
Publikováno v:
Alcoholism, clinical and experimental research. 24(11)
The mechanisms of the different sensitivity or resistance of animals and humans to alcohol are still not completely understood. For further biochemical characterization of animals genetically selected for high-alcohol sensitivity (HAS) and low-alcoho
Publikováno v:
Alcoholism, clinical and experimental research. 24(5)
Genetically based risk for development of alcoholism in humans seems to be related to initial sensitivity and/or acute tolerance to ethanol. The genetic basis for the development of tolerance has received less attention than other ethanol-related beh
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 293(1)
Genetic regulation of acute tolerance to ethanol may be associated with ethanol consumption and other ethanol-related behaviors in rodents. We have used lines of mice, selectively bred for high and low acute functional tolerance (HAFT and LAFT, respe
Publikováno v:
Alcoholism, clinical and experimental research. 22(8)
It was found that the accumulation of acetaldehyde produced from 50 mM ethanol in rat brain homogenates takes place in all major brain regions. The velocity varied between 3.5 to 7.1 nmol/mg of protein/hr. The rate increased in the following order: b
Publikováno v:
Alcoholism, clinical and experimental research. 21(4)
Ethanol sensitive long-sleep (LS) and ethanol resistant short-sleep (SS) mice are lines that have been genetically selected for differential central nervous system sensitivities to the hypnotic effect of ethanol. Because they were genetically selecte