Výsledky vyhledávání - "Rūta, Veinalde"

Akademický článek

Oncolytic measles vaccines encoding PD-1 and PD-L1 checkpoint blocking antibodies to increase tumor-specific T cell memory

Autor: Rūta Veinalde, Gemma Pidelaserra-Martí, Coline Moulin, Lara M. Jeworowski, Linda Küther, Christian J. Buchholz, Dirk Jäger, Guy Ungerechts, Christine E. Engeland

Publikováno v: Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 43-58 (2022)

PD-1/PD-L1 checkpoint blockade has achieved unprecedented success in cancer immunotherapy. Nevertheless, many immune-excluded tumors are resistant to therapy. Combination with oncolytic virotherapy may overcome resistance by inducing acute inflammati

Externí odkaz: https://doaj.org/article/b0640d5bf54b4f37a29eefe3f960eb3d

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Akademický článek

Virotherapy combined with anti-PD-1 transiently reshapes the tumor immune environment and induces anti-tumor immunity in a preclinical PDAC model

Autor: Rūta Veinalde, Gemma Pidelaserra-Martí, Coline Moulin, Chin Leng Tan, Theresa E. Schäfer, Na Kang, Claudia R. Ball, Jonas Leichsenring, Albrecht Stenzinger, Lars Kaderali, Dirk Jäger, Guy Ungerechts, Christine E. Engeland

Publikováno v: Frontiers in Immunology, Vol 13 (2023)

IntroductionPancreatic ductal adenocarcinoma (PDAC) is largely refractory to cancer immunotherapy with PD-1 immune checkpoint blockade (ICB). Oncolytic virotherapy has been shown to synergize with ICB. In this work, we investigated the combination of

Externí odkaz: https://doaj.org/article/ba74acb47dae49da8309a7f9f1784388

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Akademický článek

Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation

Autor: Rūta Veinalde, Christian Grossardt, Laura Hartmann, Marie-Claude Bourgeois-Daigneault, John C. Bell, Dirk Jäger, Christof von Kalle, Guy Ungerechts, Christine E. Engeland

Publikováno v: OncoImmunology, Vol 6, Iss 4 (2017)

Combination of oncolytic virotherapy with immunomodulators is emerging as a promising therapeutic strategy for numerous tumor entities. In this study, we developed measles Schwarz vaccine strain vectors encoding immunomodulators to support different

Externí odkaz: https://doaj.org/article/c94806dbf0f84599a829ae67877d0ae8

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Akademický článek

Immunological Effects and Viral Gene Expression Determine the Efficacy of Oncolytic Measles Vaccines Encoding IL-12 or IL-15 Agonists

Autor: Paul S. Backhaus, Rūta Veinalde, Laura Hartmann, Jessica E. Dunder, Lara M. Jeworowski, Jessica Albert, Birgit Hoyler, Tanja Poth, Dirk Jäger, Guy Ungerechts, Christine E. Engeland

Publikováno v: Viruses, Vol 11, Iss 10, p 914 (2019)

Tumor-targeted immunomodulation using oncolytic viral vectors is currently being investigated as a promising strategy in cancer therapy. In a previous study, we showed that a measles virus Schwarz vaccine strain (MeVac) vector encoding an interleukin

Externí odkaz: https://doaj.org/article/1118853372f84506bfe58b7fe879584d

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Oncolytic measles vaccines encoding PD-1 and PD-L1 checkpoint blocking antibodies to increase tumor-specific T cell memory

Autor: Christine E. Engeland, Linda Küther, Guy Ungerechts, Christian J. Buchholz, Dirk Jäger, Rūta Veinalde, Gemma Pidelaserra-Martí, Lara Maria Jeworowski, Coline Moulin

Publikováno v: Molecular therapy, 24:43-58
Molecular Therapy: Oncolytics, Vol 24, Iss, Pp 43-58 (2022)
Molecular Therapy Oncolytics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1f578f8f2b8a4e8d42ee9932982390
https://repository.publisso.de/resource/frl:6431729

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Targeted BiTE Expression by an Oncolytic Vector Augments Therapeutic Efficacy Against Solid Tumors

Autor: Tobias Speck, Christof von Kalle, Guy Ungerechts, Christine E. Engeland, Rūta Veinalde, Johannes P W Heidbuechel, Claudia R. Ball, Dirk Jaeger

Publikováno v: Clinical Cancer Research. 24:2128-2137

Purpose: Immunotherapy with bispecific T-cell engagers has achieved striking success against hematologic malignancies, but efficacy against solid tumors has been limited. We hypothesized that oncolytic measles viruses encoding bispecific T-cell engag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3b67334fafaecb69530c651111face
https://doi.org/10.1158/1078-0432.ccr-17-2651

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A Tupaia paramyxovirus vector system for targeting and transgene expression

Autor: Christoph Springfeld, Rūta Veinalde, Birgit Hoyler, Sascha Bossow, Roberto Cattaneo, Judith M Förster, Christine E. Engeland, Guy Ungerechts, Dirk Jäger, Andrew W. Hudacek

Publikováno v: Journal of General Virology. 98:2248-2257

Viruses from the diverse family of Paramyxoviridae include important pathogens and are applied in gene therapy and for cancer treatment. The Tupaia paramyxovirus (TPMV), isolated from the kidney of a tree shrew, does not infect human cells and neutra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e46297ed47963eaf8642c313b302845
https://doi.org/10.1099/jgv.0.000887

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Evaluation of Oncolytic Virus-Induced Therapeutic Tumor Vaccination Effects in Murine Tumor Models

Autor: Rūta, Veinalde

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2058

Oncolytic virotherapy is rapidly advancing into clinical practice as an appealing strategy for cancer therapy. Studies in the recent decades indicate that immunostimulatory properties of oncolytic viruses (OVs) are crucial for their therapeutic effic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5e61ac97b2be5151763e11d07efb378e
https://pubmed.ncbi.nlm.nih.gov/31486040

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