Uncoupling sodium channel dimers restores the phenotype of a pain-linked Na v 1.7 channel mutation.

Autor: Rühlmann AH; Institute of Physiology, Uniklinik RWTH Aachen University, Pauwelsstrasse 30, Aachen, Deutschland, 52074, Germany., Körner J; Institute of Physiology, Uniklinik RWTH Aachen University, Pauwelsstrasse 30, Aachen, Deutschland, 52074, Germany.; Department of Anaesthesiology, Medical Faculty, Uniklinik RWTH Aachen University, Pauwelsstrasse 30, Aachen, Deutschland, 52074, Germany., Hausmann R; Institute of Clinical Pharmacology, Uniklinik RWTH Aachen University, Pauwelsstrasse 30, Aachen, Deutschland, 52074, Germany., Bebrivenski N; Institute of Clinical Pharmacology, Uniklinik RWTH Aachen University, Pauwelsstrasse 30, Aachen, Deutschland, 52074, Germany., Neuhof C; Institute of Clinical Pharmacology, Uniklinik RWTH Aachen University, Pauwelsstrasse 30, Aachen, Deutschland, 52074, Germany., Detro-Dassen S; Institute of Clinical Pharmacology, Uniklinik RWTH Aachen University, Pauwelsstrasse 30, Aachen, Deutschland, 52074, Germany., Hautvast P; Institute of Physiology, Uniklinik RWTH Aachen University, Pauwelsstrasse 30, Aachen, Deutschland, 52074, Germany., Benasolo CA; Institute of Clinical Pharmacology, Uniklinik RWTH Aachen University, Pauwelsstrasse 30, Aachen, Deutschland, 52074, Germany.; Forschungszentrum Jülich, Institute of Biological Information Processing (IBI-1), Molekular- und Zellphysiologie, and JARA-HPC, Jülich, Germany., Meents J; Institute of Physiology, Uniklinik RWTH Aachen University, Pauwelsstrasse 30, Aachen, Deutschland, 52074, Germany., Machtens JP; Institute of Clinical Pharmacology, Uniklinik RWTH Aachen University, Pauwelsstrasse 30, Aachen, Deutschland, 52074, Germany.; Forschungszentrum Jülich, Institute of Biological Information Processing (IBI-1), Molekular- und Zellphysiologie, and JARA-HPC, Jülich, Germany., Schmalzing G; Institute of Clinical Pharmacology, Uniklinik RWTH Aachen University, Pauwelsstrasse 30, Aachen, Deutschland, 52074, Germany., Lampert A; Institute of Physiology, Uniklinik RWTH Aachen University, Pauwelsstrasse 30, Aachen, Deutschland, 52074, Germany.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2020 Oct; Vol. 177 (19), pp. 4481-4496. Date of Electronic Publication: 2020 Aug 24.