Zobrazeno 1 - 10
of 241
pro vyhledávání: '"Rüdiger Klein"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract The basolateral amygdala (BLA) contains discrete neuronal circuits that integrate positive or negative emotional information and drive the appropriate innate and learned behaviors. Whether these circuits consist of genetically-identifiable a
Externí odkaz:
https://doaj.org/article/5d7a283597794179967079a5e8f3e978
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113990- (2024)
Summary: The motivation to eat is suppressed by satiety and aversive stimuli such as nausea. The neural circuit mechanisms of appetite suppression by nausea are not well understood. Pkcδ neurons in the lateral subdivision of the central amygdala (Ce
Externí odkaz:
https://doaj.org/article/7c414c80956a496480dd23400537ce7e
Autor:
Claudia Peregrina, Sofía Zaballa, Xavier Bech, Goenuel Seyit-Bremer, Jordi Alberch, Rüdiger Klein, Daniel Del Toro
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S125- (2023)
Externí odkaz:
https://doaj.org/article/fd47fcdcb84d4a61a4a8ed71f52b57a7
Autor:
Sofía Zaballa, Yi-Ju Shen, Xavier Bech, Anna Sancho, Iván Ballasch, Jordi Alberch, Manuel Serrano, Rüdiger Klein, Maria Abad
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S151- (2023)
Externí odkaz:
https://doaj.org/article/64bff4937b0d46429a980f39de5d5b97
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Huntington’s disease (HD) is a debilitating hereditary motor disorder caused by an expansion of the CAG triplet repeat in the Huntingtin gene. HD causes neurodegeneration particularly in the basal ganglia and neocortex. In the cortex, glutamatergic
Externí odkaz:
https://doaj.org/article/97dea2aa3b3642fca57860357caa61a8
Autor:
Tobias Ruff, Christian Peters, Akihiro Matsumoto, Stephan J. Ihle, Pilar Alcalá Morales, Louise Gaitanos, Keisuke Yonehara, Daniel del Toro, Rüdiger Klein
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
The mammalian retina extracts a multitude of diverse features from the visual scene such as color, contrast, and direction of motion. These features are transmitted separately to the brain by more than 40 different retinal ganglion cell (RGC) subtype
Externí odkaz:
https://doaj.org/article/d9f4ae0645574a2cbe324b5bddaf3606
Autor:
Fabian Hosp, Sara Gutiérrez-Ángel, Martin H. Schaefer, Jürgen Cox, Felix Meissner, Mark S. Hipp, F.-Ulrich Hartl, Rüdiger Klein, Irina Dudanova, Matthias Mann
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2291-2303 (2017)
Aggregation of polyglutamine-expanded huntingtin exon 1 (HttEx1) in Huntington’s disease (HD) proceeds from soluble oligomers to late-stage inclusions. The nature of the aggregates and how they lead to neuronal dysfunction is not well understood. W
Externí odkaz:
https://doaj.org/article/6eb49d931f08402aa04d09c42c8ca559
Autor:
Verity A. Jackson, Shahid Mehmood, Matthieu Chavent, Pietro Roversi, Maria Carrasquero, Daniel del Toro, Goenuel Seyit-Bremer, Fanomezana M. Ranaivoson, Davide Comoletti, Mark S. P. Sansom, Carol V. Robinson, Rüdiger Klein, Elena Seiradake
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
FLRT proteins are known to interact with Lphns and Unc5s, mediating cell adhesion and repulsion respectively. Here the authors use crystallography, native mass spectrometry, molecular dynamics simulations and cell-based assays to show that these thre
Externí odkaz:
https://doaj.org/article/ef384409442e4b9a8531b5fb0fc42da1
Autor:
Michael S Fleming, Anna Vysochan, Sόnia Paixão, Jingwen Niu, Rüdiger Klein, Joseph M Savitt, Wenqin Luo
Publikováno v:
eLife, Vol 4 (2015)
RET can be activated in cis or trans by its co-receptors and ligands in vitro, but the physiological roles of trans signaling are unclear. Rapidly adapting (RA) mechanoreceptors in dorsal root ganglia (DRGs) express Ret and the co-receptor Gfrα2 and
Externí odkaz:
https://doaj.org/article/378ef6958d404dda95cd728777f27911
Publikováno v:
PLoS Genetics, Vol 6, Iss 8 (2010)
The most common Rhodopsin (Rh) mutation associated with autosomal dominant retinitis pigmentosa (ADRP) in North America is the substitution of proline 23 by histidine (Rh(P23H)). Unlike the wild-type Rh, mutant Rh(P23H) exhibits folding defects and f
Externí odkaz:
https://doaj.org/article/f037d599a2b847168b68427afd4d14cb