Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Rüdiger Kaspera"'
Publikováno v:
Drug Discovery and Evaluation: Methods in Clinical Pharmacology ISBN: 9783319566375
Drug Discovery and Evaluation: Methods in Clinical Pharmacology
Drug Discovery and Evaluation: Methods in Clinical Pharmacology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20dd527f949d2e300dd6a654a8cd987f
https://doi.org/10.1007/978-3-319-68864-0_3
https://doi.org/10.1007/978-3-319-68864-0_3
The role of cytochrome P450 BM3 phenylalanine-87 and threonine-268 in binding organic hydroperoxides
Autor:
John A. Thompson, Rüdiger Kaspera, Arthur G. Roberts, Ronald E. Stenkamp, Rheem A. Totah, Jonathan Katayama, Kaitlyn Ledwitch, Isolde Le Trong
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1860:669-677
Background Cytochrome P450 (P450) BM3, from Bacillus megaterium, catalyzes a wide range of chemical reactions and is routinely used as a model system to study mammalian P450 reactions and structure. Methods The metabolism of 2,6-di-tert-butyl-4-hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce5ee63447261664c0212b7b727a3b9
https://doi.org/10.1016/j.bbagen.2015.12.014
https://doi.org/10.1016/j.bbagen.2015.12.014
Publikováno v:
Drug Metabolism and Disposition. 41:2087-2094
Cytochrome P450 2J2 plays a significant role in the epoxidation of arachidonic acid to signaling molecules important in cardiovascular events. CYP2J2 also contributes to drug metabolism and is responsible for the intestinal clearance of ebastine. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e213064d88f67582205d1be30635e506
https://doi.org/10.1124/dmd.113.053389
https://doi.org/10.1124/dmd.113.053389
Autor:
Pui-Yan Kwok, Deanna L. Kroetz, Bruce M. Psaty, Rüdiger Kaspera, Kristin D. Marciante, Bani Tamraz, Catherine Chu, James S. Floyd, Rheem A. Totah, Hisayo Fukushima, Susan R. Heckbert, Benjamin Ma, Alan R. Wolfe
Publikováno v:
Pharmacogenetics and Genomics. 23:355-364
Genetic variation in drug metabolizing enzymes and membrane transporters as well as concomitant drug therapy can modulate the beneficial and the deleterious effects of drugs. We investigated whether patients exhibiting rhabdomyolysis who were taking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661aab319d453760aa193419771a856f
https://doi.org/10.1097/fpc.0b013e3283620c3b
https://doi.org/10.1097/fpc.0b013e3283620c3b
Autor:
Rüdiger Kaspera, Brianne S. Raccor
Publikováno v:
Current Topics in Medicinal Chemistry. 13:1441-1453
Cytochrome P450 isozymes (CYPs) from the CYP1 and CYP2 families located primarily in extra-hepatic tissues represent ideal candidates for chemotherapeutic drug development because: 1.) They are usually involved in the metabolism of endogenous substra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36770636f226ff2b374f26373cd2a1c
https://doi.org/10.2174/1568026611313120006
https://doi.org/10.2174/1568026611313120006
Autor:
Hideo Takakusa, Edward J. Kelly, Terrance J. Kavanagh, Isaac Mohar, Sidney D. Nelson, Rüdiger Kaspera
Publikováno v:
Biochemical and Biophysical Research Communications. 420:54-60
Mitochondria are the primary locus for the generation of reactive nitrogen species including peroxynitrite and subsequent protein tyrosine nitration. Protein tyrosine nitration may have important functional and biological consequences such as alterat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b7036e57c460051e83bc7716fa0865
https://doi.org/10.1016/j.bbrc.2012.02.114
https://doi.org/10.1016/j.bbrc.2012.02.114
Publikováno v:
Biochemical and Biophysical Research Communications. 418:464-468
Highlights: Black-Right-Pointing-Pointer Cytochrome P450BM-3 reduced aldehydes to alcohols efficiently (k{sub cat} {approx} 25 min{sup -1}). Black-Right-Pointing-Pointer Reduction is a direct hydride transfer from R-NADP{sup 2}H to the carbonyl moiet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240f17183af110970ff83107819de88c
https://doi.org/10.1016/j.bbrc.2012.01.040
https://doi.org/10.1016/j.bbrc.2012.01.040
Autor:
Eric A. Evangelista, Kristin D. Marciante, Bruce M. Psaty, Suresh Babu Naraharisetti, Rüdiger Kaspera, Rheem A. Totah
Publikováno v:
Biochemical Pharmacology. 82:681-691
Genetic polymorphisms in CYP2C8 can influence the metabolism of important therapeutic agents and cause interindividual variation in drug response and toxicity. The significance of the variant CYP2C8*3 has been controversial with reports of higher in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda6df0b4d1598984fe6840d4ddd225f
https://doi.org/10.1016/j.bcp.2011.06.027
https://doi.org/10.1016/j.bcp.2011.06.027
Autor:
Rüdiger Kaspera, Kristin D. Marciante, Barbara McKnight, Pui-Yan Kwok, Rheem A. Totah, Cashell E. Jaquish, Kenneth Rice, Thomas R. Austin, Thomas Lumley, Russell P. Tracy, Hisayo Fukushima, Susan R. Heckbert, Kent D. Taylor, Guo Li, Bruce M. Psaty, Bani Tamraz, Jon P. Durda, Nicole L. Glazer, Joshua C. Bis, Jerome I. Rotter, Deanna L. Kroetz
Publikováno v:
Pharmacogenetics and Genomics. 21:280-288
The withdrawal of cerivastatin involved an uncommon but serious adverse reaction, rhabdomyolysis. The bimodal response, rhabdomyolysis in a small proportion of users, points to genetic factors as a potential cause. We conducted a case-control study t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453d41f04afd2ebdb0e3f1f5f1cb22a5
https://doi.org/10.1097/fpc.0b013e328343dd7d
https://doi.org/10.1097/fpc.0b013e328343dd7d
Autor:
Manfred Nimtz, Stephanie Johanna Luise Riemer, Holger Zorn, Marco A. Fraatz, Ralf G. Berger, Regina Stöber, Rüdiger Kaspera
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 61:202-207
A selective and highly efficient allylic oxidation of the sesquiterpene (+)-valencene to (+)-nootkatone was achieved with lyophilisate of the basidiomycete Pleurotus sapidus . The responsible enzymatic activity was biochemically characterised and pur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60552a8e8ccb8940730de63f35cf9044
https://doi.org/10.1016/j.molcatb.2009.07.001
https://doi.org/10.1016/j.molcatb.2009.07.001