Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Rüdiger Hardeland"'
Autor:
Martin Begemann, Oliver Gross, Dominik Wincewicz, Rüdiger Hardeland, Vinicius Daguano Gastaldi, Eduard Vieta, Karin Weissenborn, Kamilla W. Miskowiak, Onnen Moerer, Hannelore Ehrenreich
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-11 (2021)
Abstract Background Since fall 2019, SARS-CoV-2 spread world-wide, causing a major pandemic with estimated ~ 220 million subjects affected as of September 2021. Severe COVID-19 is associated with multiple organ failure, particularly of lung and kidne
Externí odkaz:
https://doaj.org/article/c764cb158b544a908f44c5ae00e1db3b
Autor:
Justus B. H. Wilke, Martin Hindermann, Amir Moussavi, Umer Javed Butt, Rakshit Dadarwal, Stefan A. Berghoff, Aref Kalantari Sarcheshmeh, Anja Ronnenberg, Svenja Zihsler, Sahab Arinrad, Rüdiger Hardeland, Jan Seidel, Fred Lühder, Klaus-Armin Nave, Susann Boretius, Hannelore Ehrenreich
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-19 (2021)
Abstract Up to one person in a population of 10,000 is diagnosed once in lifetime with an encephalitis, in 50–70% of unknown origin. Recognized causes amount to 20–50% viral infections. Approximately one third of affected subjects develops modera
Externí odkaz:
https://doaj.org/article/d1c0fb1e847c4676a294adfd696ee12d
Autor:
Fang He, Xiaoyan Wu, Qingzhuo Zhang, Yikun Li, Yuyi Ye, Pan Li, Shuai Chen, Yuanyi Peng, Rüdiger Hardeland, Yaoyao Xia
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Diseases caused by pathogenic bacteria in animals (e.g., bacterial pneumonia, meningitis and sepsis) and plants (e.g., bacterial wilt, angular spot and canker) lead to high prevalence and mortality, and decomposition of plant leaves, respectively. Me
Externí odkaz:
https://doaj.org/article/bcdceb554b40400b99df5d76d79807bb
Autor:
Rüdiger Hardeland
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 1971 (2022)
Melatonin interacts with various types of stem cells, in multiple ways that comprise stimulation of proliferation, maintenance of stemness and self-renewal, protection of survival, and programming toward functionally different cell lineages. These va
Externí odkaz:
https://doaj.org/article/28d021be74ef4c9da0050fe4f97a7e3f
Autor:
Dun-Xian Tan, Rüdiger Hardeland
Publikováno v:
Molecules, Vol 26, Iss 23, p 7302 (2021)
In this article, we attempt to classify a potential dimorphism of melatonin production. Thus, a new concept of “reserve or maximum capacity of melatonin synthetic function” is introduced to explain the subtle dimorphism of melatonin production in
Externí odkaz:
https://doaj.org/article/384ab1d7243a4bc4ac76384b0a360589
Autor:
Rüdiger Hardeland
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8296 (2021)
Melatonin interacts in multiple ways with microglia, both directly and, via routes of crosstalk with astrocytes and neurons, indirectly. These effects of melatonin are of relevance in terms of antioxidative protection, not only concerning free-radica
Externí odkaz:
https://doaj.org/article/552af4de0fa24d7ab067c717d9c8423c
Autor:
Rüdiger Hardeland
Publikováno v:
Molecules, Vol 26, Iss 13, p 4105 (2021)
Melatonin and several of its metabolites are interfering with reactive nitrogen. With the notion of prevailing melatonin formation in tissues that exceeds by far the quantities in blood, metabolites come into focus that are poorly found in the circul
Externí odkaz:
https://doaj.org/article/c7aa30195dad40b99aa47f89effa5671
Autor:
Rüdiger Hardeland
Publikováno v:
Diseases, Vol 9, Iss 1, p 18 (2021)
Melatonin has been used preclinically and clinically for different purposes. Some applications are related to readjustment of circadian oscillators, others use doses that exceed the saturation of melatonin receptors MT1 and MT2 and are unsuitable for
Externí odkaz:
https://doaj.org/article/c77c9c9d914c4d87b624c33e9881650a
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8806 (2020)
For years the thymus gland (TG) and the pineal gland (PG) have been subject of increasingly in-depth studies, but only recently a link that can associate the activities of the two organs has been identified. Considering, on the one hand, the well-kno
Externí odkaz:
https://doaj.org/article/bcb2b59ad0a34893b1b83e23bf130539
Autor:
Rüdiger Hardeland
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 10, Pp 18221-18252 (2014)
Melatonin is a highly pleiotropic regulator molecule, which influences numerous functions in almost every organ and, thus, up- or down-regulates many genes, frequently in a circadian manner. Our understanding of the mechanisms controlling gene expres
Externí odkaz:
https://doaj.org/article/52004b4f05724b43b7e29306ddbddc0e