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N-terminal domain of human Hsp90 triggers binding to the cochaperone p23

Autor: Karagöz, G. Elif, Duarte, Afonso M. S., Ippel, Hans, Uetrecht, Charlotte, Sinnige, Tessa, van Rosmalen, Martijn, Hausmann, Jens, Heck, Albert J. R., Boelens, Rolf, Rüdiger, Stefan G. D., Lindquist, Susan

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2011 Jan 01. 108(2), 580-585.

Externí odkaz: https://www.jstor.org/stable/25770824

Molecular Strategies to Target Protein Aggregation in Huntington’s Disease

Autor: Jarosińska, Olga D, Rüdiger, Stefan G D, Sub Developmental Biology, Sub Cellular Protein Chemistry, Cellular Protein Chemistry

Publikováno v: Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 8 (2021)
Frontiers in Molecular Biosciences, 8, 1. Frontiers Media S.A.

Huntington’s disease (HD) is a neurodegenerative disorder caused by the aggregation of the mutant huntingtin (mHTT) protein in nerve cells. mHTT self-aggregates to form soluble oligomers and insoluble fibrils, which interfere in a number of key cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eac3618fb74831a39d7c58024921f8a
http://europepmc.org/articles/PMC8636123

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Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau

Autor: Ferrari, Luca, Stucchi, Riccardo, Konstantoulea, Katerina, van de Kamp, Gerarda, Kos, Renate, Geerts, Willie J C, van Bezouwen, Laura S, Förster, Friedrich G, Altelaar, Maarten, Hoogenraad, Casper C, Rüdiger, Stefan G D, Cryo-EM, Cellular Protein Chemistry, Biomolecular Mass Spectrometry and Proteomics, Celbiologie, Sub Cellular Protein Chemistry, Sub Cell Biology, Sub Cryo - EM, Afd Biomol.Mass Spect. and Proteomics

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature communications, 11(1):571. Nature Publishing Group
Nature Communications, 11(1), 1. Nature Publishing Group

Aggregation of the Tau protein into fibrils defines progression of neurodegenerative diseases, including Alzheimer’s Disease. The molecular basis for potentially toxic reactions of Tau aggregates is poorly understood. Here we show that π-stacking

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11148cec699bdec76606e71b3d1338d4
https://doi.org/10.1038/s41467-019-13745-7