Polyol pathway-generated fructose is indispensable for growth and survival of non-small cell lung cancer.

Autor: Schwab A; Interdisciplinary Center for Clinical Research (IZKF), Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.; Experimental Medicine 1, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany., Siddiqui MA; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Ramesh V; Interdisciplinary Center for Clinical Research (IZKF), Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Gollavilli PN; Interdisciplinary Center for Clinical Research (IZKF), Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Turtos AM; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Møller SS; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Pinna L; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Havelund JF; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Rømer AMA; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Ersan PG; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.; Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey., Parma B; Interdisciplinary Center for Clinical Research (IZKF), Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.; Laboratory of Immunobiology, Université Libre de Bruxelles- Faculty of Science, Brussels, Belgium., Marschall S; Interdisciplinary Center for Clinical Research (IZKF), Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany., Dettmer K; Institute of Functional Genomics, University of Regensburg, Regensburg, Germany., Alhusayan M; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Bioenergetics & Neurometabolism, Dasman Diabetes Institute, Dasman, Kuwait., Bertoglio P; Division of Thoracic Surgery, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy., Querzoli G; Pathology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy.; Ospedale Sacro Cuore Don Calabria, Verona, Italy., Mielenz D; Division of Molecular Immunology, Department of Internal Medicine 3, Friedrich-Alexander Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Nikolaus-Fiebiger-Center, Erlangen, Germany., Sahin O; Department of Biochemistry & Molecular Biology - College of Medicine, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA., Færgeman NJ; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Asangani IA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ceppi P; Interdisciplinary Center for Clinical Research (IZKF), Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany. pceppi@bmb.sdu.dk.; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark. pceppi@bmb.sdu.dk.

Publikováno v: Cell death and differentiation [Cell Death Differ] 2024 Nov 20. Date of Electronic Publication: 2024 Nov 20.

Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment.

Autor: Fjæstad KY; National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark.; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Rømer AMA; National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark.; Department of Science and Environment, Roskilde University, Roskilde, Denmark., Goitea V; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Johansen AZ; National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark., Thorseth ML; National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark.; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Carretta M; National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark., Engelholm LH; Finsen Laboratory, Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark., Grøntved L; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Junker N; Department of Oncology, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark., Madsen DH; National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark. daniel.hargboel.madsen@regionh.dk.; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark. daniel.hargboel.madsen@regionh.dk.

Publikováno v: Oncogene [Oncogene] 2022 Feb; Vol. 41 (9), pp. 1364-1375. Date of Electronic Publication: 2022 Jan 11.