Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rômulo F. S. Canto"'
Autor:
Giancarlo V. Botteselle, Welman C. Elias, Luana Bettanin, Rômulo F. S. Canto, Drielly N. O. Salin, Flavio A. R. Barbosa, Sumbal Saba, Hugo Gallardo, Gianluca Ciancaleoni, Josiel B. Domingos, Jamal Rafique, Antonio L. Braga
Publikováno v:
Molecules, Vol 26, Iss 15, p 4446 (2021)
Herein, we describe a simple and efficient route to access aniline-derived diselenides and evaluate their antioxidant/GPx-mimetic properties. The diselenides were obtained in good yields via ipso-substitution/reduction from the readily available 2-ni
Externí odkaz:
https://doaj.org/article/5ed3b569fb7744dbb50e46937ac87b9c
Autor:
Bruna G. S. Torres, Flávia D. T. Uchôa, Rômulo F. S. Canto, Allan Crestani, Vera Eifler-Lima, Teresa Dalla Costa
Publikováno v:
Química Nova, Vol 37, Iss 3, Pp 461-464 (2014)
A simple HPLC/UV method was developed for the determination of the anticancer candidate LaSOM 65 in rat plasma. Samples were cleaned by protein precipitation with acetonitrile (recovery > 95%), after which they were subjected to chromatography under
Externí odkaz:
https://doaj.org/article/fa3081fad5934af4b44b08b5d6c55909
Autor:
Ruth L. Quispe, Michael L. Jaramillo, Ingrid A. V. Wolin, Rômulo F. S. Canto, Flavio A. R. Barbosa, Antônio L. Braga, João B. T. Rocha, Michael Aschner, Rodrigo B. Leal, Andreza F. de Bem, Marcelo Farina
Publikováno v:
Neurotoxicity Research. 40:127-139
Autor:
Luana Candice Genz Bazana, Theo V. C. Russo, Alexandre Meneghello Fuentefria, William Lopes, Marcus M. Sá, Mário Lettieri Teixeira, Ânderson Ramos Carvalho, Rômulo F. S. Canto, Flavio A. R. Barbosa, Luís Flávio Souza de Oliveira, Marilene Henning Vainstein, Gustavo Pozza Silveira
Publikováno v:
ChemistrySelect. 5:10495-10500
Autor:
Ruth L, Quispe, Michael L, Jaramillo, Ingrid A V, Wolin, Rômulo F S, Canto, Flavio A R, Barbosa, Antônio L, Braga, João B T, Rocha, Michael, Aschner, Rodrigo B, Leal, Andreza F, de Bem, Marcelo, Farina
Publikováno v:
Neurotoxicity research. 40(1)
Methylmercury (MeHg) is a ubiquitous environmental neurotoxicant whose mechanisms of action involve oxidation of endogenous nucleophilic groups (mainly thiols and selenols), depletion of antioxidant defenses, and disruption of neurotransmitter homeos
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:5762-5770
This paper describes the synthesis and evaluation of new dihydropyrimidinone (DHPM)-derived selenoesters as potential multi-targeted agents for the treatment of Alzheimer's disease. A series of DHPM-derived selenoesters were obtained with high struct
Publikováno v:
Current Organic Chemistry. 20:166-188
Organoselenium compounds are molecules with important potential therapeutic applications. Selenium-containing 5-membered heterocycles have emerged as an important class of biological compounds. In the past five years, several articles related to the
Synthesis and Biological Evaluation of 2-Picolylamide-Based Diselenides with Non-Bonded Interactions
Autor:
Rômulo F. S. Canto, Tiago Elias Allievi Frizon, Maryam Jan, Sumbal Saba, Waseem Hassan, João Rocha, Jamal Rafique, Emily Pansera Waczuk, Davi F. Back, Antonio L. Braga
Publikováno v:
Molecules, Vol 20, Iss 6, Pp 10095-10109 (2015)
Molecules
Volume 20
Issue 6
Pages 10095-10109
Molecules
Volume 20
Issue 6
Pages 10095-10109
In this paper, we report the synthesis and biological evaluation of picolylamide-based diselenides with the aim of developing a new series of diselenides with O···Se non-bonded interactions. The synthesis of diselenides was performed by a simple a
Autor:
Claudio Santi, Natasha L. Ferreira, Vanessa Nascimento, Emily Pansera Waczuk, Luca Sancineto, Antonio L. Braga, Rômulo F. S. Canto, João Rocha, Karen Lílian Schott
Publikováno v:
European Journal of Medicinal Chemistry. 87:131-139
The antioxidant properties of organoselenium compounds have been extensively investigated with the aim of developing new drugs, since oxidative stress is responsible for a variety of chronic human diseases. Herein, we reported the synthesis of new ni
Autor:
Marcel Henrique Marcondes Sari, Carla Elena Sartori Oliveira, Pietro Maria Chagas, Cristina W. Nogueira, Sônia Cristina Almeida da Luz, Rômulo F. S. Canto, Antonio L. Braga, Suzan Gonçalves Rosa
Publikováno v:
Pharmacology Biochemistry and Behavior. 118:87-95
The present study evaluated the antinociceptive and anti-inflammatory effects of per oral (p.o.) administration of salicylic acid-derivative organoselenium compounds in chemical models of nociception in mice. The compounds (50 mg/kg; p.o.) were admin