Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Rózsa Hegedüs"'
Autor:
Eszter Lajkó, Sarah Spring, Rózsa Hegedüs, Beáta Biri-Kovács, Sven Ingebrandt, Gábor Mező, László Kőhidai
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 2495-2509 (2018)
Background: Peptide hormone-based targeted tumor therapy is an approved strategy to selectively block the tumor growth and spreading. The gonadotropin-releasing hormone receptors (GnRH-R) overexpressed on different tumors (e.g., melanoma) could be ut
Externí odkaz:
https://doaj.org/article/8fbdc195542345c69ea27f0ff4c714bb
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4421 (2019)
The wide range of cellular target reactions (e.g., antitumor) of gonadotropin-releasing hormone (GnRH) variants provides the possibility to develop multifunctional GnRH conjugates. The aim of our work was to compare the cytotoxic/apoptotic activity o
Externí odkaz:
https://doaj.org/article/c754b79d971d46d0ad875417b2950952
Autor:
Zsolt Dürvanger, Eszter Boros, Zoltán Attila Nagy, Rózsa Hegedüs, Márton Megyeri, József Dobó, Péter Gál, Gitta Schlosser, Annamária F. Ángyán, Zoltán Gáspári, András Perczel, Veronika Harmat, Gábor Mező, Dóra K. Menyhárd, Gábor Pál
Publikováno v:
ACS Chemical Biology. 17:969-986
MASP-1 and MASP-2 are key activator proteases of the complement lectin pathway. The first specific mannose-binding lectin-associated serine protease (MASP) inhibitors had been developed from the 14-amino-acid sunflower trypsin inhibitor (SFTI) peptid
Autor:
Sven Ingebrandt, Gábor Mező, Eszter Lajkó, Rózsa Hegedüs, Beáta Biri-Kovács, Sarah Spring, László Kőhidai
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 2495-2509 (2018)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
Background: Peptide hormone-based targeted tumor therapy is an approved strategy to selectively block the tumor growth and spreading. The gonadotropin-releasing hormone receptors (GnRH-R) overexpressed on different tumors (e.g., melanoma) could be ut
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 18
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4421 (2019)
Volume 20
Issue 18
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4421 (2019)
The wide range of cellular target reactions (e.g., antitumor) of gonadotropin-releasing hormone (GnRH) variants provides the possibility to develop multifunctional GnRH conjugates. The aim of our work was to compare the cytotoxic/apoptotic activity o
Autor:
József Tóvári, Marilena Manea, Bence Kapuvári, Rózsa Hegedüs, Alexandra Gacs, Borbála Vincze, Ákos Schulcz, Gábor Mező
Publikováno v:
Investigational New Drugs
SummaryCompared to classical chemotherapy, peptide-based drug targeting is a promising therapeutic approach for cancer, which can provide increased selectivity and decreased side effects to anticancer drugs. Among various homing devices, gonadotropin
Autor:
Bence, Kapuvári, Ákos, Schulcz, Rózsa, Hegedüs, Ildikó, Szabó, Marilena, Manea, Borbála, Vincze, József, Tóvári, Alexandra, Gacs, Miguel, Tejeda, Dezsõ, Gaál, Gábor, Mezõ
Publikováno v:
Magyar onkologia. 59(4)
Targeted tumor therapy is a perspective procedure to specifically destroy the cancer tissues with eliminating or at least decreasing the side effects of anticancer drugs. For this purpose the drug molecule is attached to a targeting moiety (e.g. pept
Autor:
Gábor Mező, Ildikó Szabó, Andreas Marquardt, Erika Orbán, Aline Pauschert, Marilena Manea, Rózsa Hegedüs, David Andreu
Publikováno v:
Biopolymers. 104(3)
Daunorubicin-GnRH-III bioconjugates have recently been developed as drug delivery systems with potential applications in targeted cancer chemotherapy. In order to improve their biochemical properties, several strategies have been pursued: (1) incorpo
Autor:
Ildikó Szabó, Marilena Manea, Rózsa Hegedüs, Éva Sipos, Éva Kiss, Gabor Halmos, Erika Orbán, Gábor Mező
Here we report on the synthesis and biochemical characterization (enzymatic stability, cellular uptake, in vitro antitumor activity, membrane interaction and GnRH-receptor binding affinity) of novel short-chain fatty acid (SCFA) acylated daunorubicin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851c2085ded97e60e6d7e532058b9f67
Autor:
Erika Orbán, Gabor Halmos, Ulrike Leurs, Marilena Manea, István Kertész, Rózsa Hegedüs, Szilvia Bösze, Ildikó Szabó, Gábor Mezö
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 17(1)
Owing to the high chemoselectivity between an aminooxy function and a carbonyl group, oxime ligation is one of the most preferred procedures for the preparation of peptide conjugates. However, the sensitivity of (aminooxy)acetylated peptides to keton