Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Róisín M. Loftus"'
Autor:
Róisín M. Loftus, Nadine Assmann, Nidhi Kedia-Mehta, Katie L. O’Brien, Arianne Garcia, Conor Gillespie, Jens L. Hukelmann, Peter J. Oefner, Angus I. Lamond, Clair M. Gardiner, Katja Dettmer, Doreen A. Cantrell, Linda V. Sinclair, David K. Finlay
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Glutamine can feed into the TCA cycle as a fuel for oxidative phosphorylation and thereby can affect metabolic pathways in lymphocytes. Yet here the authors show that glutamine serves predominantly as a signalling molecule that sustains cMyc expressi
Externí odkaz:
https://doaj.org/article/428103db6a8c40348a0ae092d9d2a982
Autor:
Xavier Michelet, Róisín M. Loftus, Kingston H. G. Mills, Danielle Duquette, Andrew E. Hogan, Lydia Lynch, Barbara S. Nikolajczyk, Michael B. Brenner, Lydia Dyck, Cliona O'Farrelly, Cathriona Foley, Ashley H. Vernon, David K. Finlay, William Pettee, Raymond P. Donnelly, Kevin Wei, Ali Tavakkoli, Semir Beyaz, Mathilde Raverdeau, Donal O'Shea
Publikováno v:
Nature Immunology
Up to 49% of certain types of cancer are attributed to obesity, and potential mechanisms include overproduction of hormones, adipokines, and insulin. Cytotoxic immune cells, including natural killer (NK) cells and CD8+ T cells, are important in tumor
Autor:
Ayano C. Kohlgruber, Claire McIntyre, Bruno Silva-Santos, Mathilde Raverdeau, Lydia Dyck, Noëlla Lopes, Róisín M. Loftus, Leandro Z. Agudelo, Rafael J. Argüello, Nital Sumaria, Aaron Douglas, Philippe Pierre, Manolis Kellis, Hannah Prendeville, Harry Kane, Stefania Martin, Stephen Cunningham, Daniel J. Pennington, Michael B. Brenner, Gina J. Fiala, Colleen Carmody, Lydia Lynch
Publikováno v:
Nature immunology
Nature Immunology
Nature Immunology, Nature Publishing Group, 2021, 22 (2), pp.179-192. ⟨10.1038/s41590-020-00848-3⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Immunology, 2021, 22 (2), pp.179-192. ⟨10.1038/s41590-020-00848-3⟩
Nature Immunology
Nature Immunology, Nature Publishing Group, 2021, 22 (2), pp.179-192. ⟨10.1038/s41590-020-00848-3⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Immunology, 2021, 22 (2), pp.179-192. ⟨10.1038/s41590-020-00848-3⟩
© The Author(s), under exclusive licence to Springer Nature America, Inc. 2021
Metabolic programming controls immune cell lineages and functions, but little is known about γδ T cell metabolism. Here, we found that γδ T cell subsets making e
Metabolic programming controls immune cell lineages and functions, but little is known about γδ T cell metabolism. Here, we found that γδ T cell subsets making e
Autor:
Vanessa Zaiatz-Bittencourt, Nadine Assmann, Lydia Lynch, Clair M. Gardiner, Róisín M. Loftus, Raymond P. Donnelly, Katie L. O’Brien, David K. Finlay, Katja Dettmer, Paul Heinrich, Peter J. Oefner, Lydia Dyck
Publikováno v:
Nature Immunology. 18:1197-1206
Activated natural killer (NK) cells engage in a robust metabolic response that is required for normal effector function. Using genetic, pharmacological and metabolic analyses, we demonstrated an essential role for Srebp transcription factors in cytok
Autor:
Ronan Bergin, Natacha Veerapen, Donal O'Shea, Cathriona Foley, Andrew E. Hogan, Gurdyal S. Besra, Frances C. Tinley, Róisín M. Loftus, Marta M. Pisarska, Arimin Mat, Laura Tobin, Ciaran Bannan, Paul N. Moynagh, Gary Sommerville, Linda V. Sinclair, Aisling M. O'Brien, David K. Finlay, Lydia Lynch, Nicole A. W. Wood
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 202(12)
Obesity underpins the development of numerous chronic diseases, such as type II diabetes mellitus. It is well established that obesity negatively alters immune cell frequencies and functions. Mucosal-associated invariant T (MAIT) cells are a populati
Autor:
Vanessa Zaiatz-Bittencourt, Clair M. Gardiner, C Keane, Róisín M. Loftus, Kiva Brennan, Sinead E. Keating, David K. Finlay
Publikováno v:
The Journal of Immunology. 196:2552-2560
Human NK cells can be classified into phenotypically and functionally distinct subsets based on levels of CD56 receptor. CD56dim cells are generally considered more cytotoxic, whereas the CD56bright cells are potent producers of IFN-γ. In this study
Autor:
Clair M. Gardiner, Nidhi Kedia-Mehta, Arianne Garcia, Doreen A. Cantrell, Nadine Assmann, Katja Dettmer, Peter J. Oefner, Linda V. Sinclair, Katie L. O’Brien, David K. Finlay, Angus I. Lamond, Jens L. Hukelmann, Róisín M. Loftus, Conor Gillespie
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Natural killer (NK) cells are lymphocytes with important anti-tumour functions. Cytokine activation of NK cell glycolysis and oxidative phosphorylation (OXPHOS) are essential for robust NK cell responses. However, the mechanisms leading to this metab
Autor:
Clair M. Gardiner, Sinead E. Keating, Kevin T. Liou, Christine A. Biron, Róisín M. Loftus, David K. Finlay, Raymond P. Donnelly
Publikováno v:
The Journal of Immunology. 193:4477-4484
The mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cellular metabolism and also has fundamental roles in controlling immune responses. Emerging evidence suggests that these two functions of mTORC1 are integrally linked. Howeve
Autor:
Nicholas D. Huntington, Jessica Rabilloud, Amélien Sanlaville, Sophie Degouve, Jacqueline Marvel, Sébastien Viel, Fernando Souza Fonseca Guimaraes, Sophia Djebali, Antoine Marçais, Morgan Grau, Mark J. Smyth, Thierry Walzer, Emily Charrier, Jacques Bienvenu, Róisín M. Loftus, Liam Town, David K. Finlay, Christophe Caux, Laurent Bartholin, Julien C. Marie
Publikováno v:
Science Signaling
Science Signaling, American Association for the Advancement of Science, 2016, 9 (415), pp.ra19-ra19. ⟨10.1126/scisignal.aad1884⟩
Science Signaling, 2016, 9 (415), pp.ra19-ra19. ⟨10.1126/scisignal.aad1884⟩
Science Signaling, American Association for the Advancement of Science, 2016, 9 (415), pp.ra19-ra19. ⟨10.1126/scisignal.aad1884⟩
Science Signaling, 2016, 9 (415), pp.ra19-ra19. ⟨10.1126/scisignal.aad1884⟩
International audience; Transforming growth factor-beta (TGF-beta) is a major immunosuppressive cytokine that maintains immune homeostasis and prevents autoimmunity through its antiproliferative and anti-inflammatory properties in various immune cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ab34fa0525f63f70c4aa737c517f1d
https://hal-univ-lyon1.archives-ouvertes.fr/hal-01796190
https://hal-univ-lyon1.archives-ouvertes.fr/hal-01796190
Autor:
Róisín M. Loftus, David K. Finlay
Publikováno v:
The Journal of biological chemistry. 291(1)
Immune cells are highly dynamic in terms of their growth, proliferation, and effector functions as they respond to immunological challenges. Different immune cells can adopt distinct metabolic configurations that allow the cell to balance its require