Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Réparation d'ADN"'
Autor:
G, Ploussard, J-B, Beauval, R, Mathieu, E, Barret, L, Brureau, G, Créhange, C, Dariane, G, Fiard, M, Gauthé, R, Renard-Penna, A, Ruffion, P, Sargos, M, Rouprêt, G, Roubaud, G, Fromont
Publikováno v:
Progrès en Urologie
Progrès en Urologie, 2022, ⟨10.1016/j.purol.2021.12.007⟩
Progrès en Urologie, 2022, ⟨10.1016/j.purol.2021.12.007⟩
National audience; INTRODUCTION: Current therapeutic developments in prostate cancer (PCa) tend to increasingly personalize the treatment strategy, in particular as a function of tumor genomics. Recently, poly ADP-ribose polymerase (PARPi) inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3a14374c980b1ceba0ac811d7c40e39b
https://hal.science/hal-03578125
https://hal.science/hal-03578125
Autor:
Simanov, Gleb
At the leading edge, membrane protrusions called lamellipodia are driven by Arp2/3-mediated actin polymerization. This process is orchestrated by the small GTPase Rac1 that activates the WAVE complex by exposing its WCA domain. Different positive fee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______166::f56186b60c030086dcbedec2f5bd32c0
https://theses.hal.science/tel-03767526
https://theses.hal.science/tel-03767526
Autor:
Portman, James
R-loop structures pose a threat to genomic integrity because their formation can lead to mutagenesis. Mutagenesis drives antibiotic resistance in bacteria and chemotherapy resistance in human cancers, therefore it is important to understand how R-loo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______166::8354d048d8969918a0dc45febc9b2ec5
https://theses.hal.science/tel-03941562
https://theses.hal.science/tel-03941562
Publikováno v:
Biochemistry and cell biology = Biochimie et biologie cellulaire
FK506-binding proteins (FKBPs) alter the conformation of proteins via cis-trans isomerization of prolyl-peptide bonds. While this activity can be demonstrated in vitro, the intractability of detecting prolyl isomerization events in cells has limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b165703e3dd0b941d3c45552a2095a06
http://europepmc.org/articles/PMC7457334
http://europepmc.org/articles/PMC7457334
Autor:
France, Benoît
Publikováno v:
Biologie cellulaire. Université Sorbonne Paris Cité, 2018. Français. ⟨NNT : 2018USPCB072⟩
For the last 20 years, important knowledge were acquired regarding the implication of the DNA damage response (DDR) in the development, maturation and function of the immune system. The lab DGSI has shown that DNA repair deficiencies can lead to immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::859c66f59f7784502d5af7aeb2fa8ad8
https://tel.archives-ouvertes.fr/tel-02510917
https://tel.archives-ouvertes.fr/tel-02510917
Autor:
Lowry, Carolyne Mary
5-Methylcytosine is an epigenetic mark, which can be oxidized to 5-hydroxymethylcytosine (5hmC) in DNA by ten-eleven translocation (TET) oxygenases. It is an initial step in the demethylation of 5mC. Levels of 5hmC is relatively high in the brain com
Externí odkaz:
http://hdl.handle.net/11143/9864
Autor:
Nicolai, Catharina von
Les mutations héréditaires dans le gène BRCA2 sont associées à une forte susceptibilité au développement du cancer du sein et de l’ovaire. La protéine suppresseur de tumeur BRCA2 est essentielle pour préserver l’intégrité des chromosom
Externí odkaz:
http://www.theses.fr/2016SACLS123/document
Autor:
Nicolai, Catharina von
Publikováno v:
Biochemistry [q-bio.BM]. Université Paris Saclay (COmUE), 2016. English. ⟨NNT : 2016SACLS123⟩
Germline mutations in the BRCA2 gene lead to high susceptibility to the development of breast and ovarian cancer. The tumor suppressor protein BRCA2 is essential for preserving chromosome integrity after DNA damage emerging from endogenous or exogeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4ceeed338dacb806fa80e3449042ccfc
https://tel.archives-ouvertes.fr/tel-01336886/file/71121_VONNICOLAI_2016_archivage.pdf
https://tel.archives-ouvertes.fr/tel-01336886/file/71121_VONNICOLAI_2016_archivage.pdf
Autor:
Biola-Clier, Mathilde
Le dioxyde de titane (TiO2) compte parmi les nanoparticules (NP) les plus produites dans le monde. Ce constat soulève la question de sa toxicité, en particulier par inhalation, voie d'exposition la plus probable en milieu professionnel. Il a été
Externí odkaz:
http://www.theses.fr/2016GREAV004/document
Autor:
Kotula, Ewa
La protéine kinase dépendante de l’ADN (DNA-PK) est une sérine-thréonine kinase qui est un élément essentiel dans la voie de réparation de l’ADN endommagé par recombinaison non-homologue (non-homologous end-joining; NHEJ). DNA-PK est éga
Externí odkaz:
http://www.theses.fr/2014PA11T021