Výsledky vyhledávání - "Rémy Bosselut"

Akademický článek

Redefining the Foreign Antigen and Self-Driven Memory CD4+ T-Cell Compartments via Transcriptomic, Phenotypic, and Functional Analyses

Autor: Takeshi Kawabe, Thomas Ciucci, Kwang Soon Kim, Shunichi Tayama, Akihisa Kawajiri, Takumi Suzuki, Riou Tanaka, Naoto Ishii, Dragana Jankovic, Jinfang Zhu, Jonathan Sprent, Rémy Bosselut, Alan Sher

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Under steady-state conditions, conventional CD4+ T lymphocytes are classically divided into naïve (CD44lo CD62Lhi) and memory (CD44hi CD62Llo) cell compartments. While the latter population is presumed to comprise a mixture of distinct subpopulation

Externí odkaz: https://doaj.org/article/d66f6ac930a24af8947edeb2266a5f97

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Akademický článek

The NF-κB regulator Bcl-3 restricts terminal differentiation and promotes memory cell formation of CD8+ T cells during viral infection.

Autor: Hemant Jaiswal, Thomas Ciucci, Hongshan Wang, Wanhu Tang, Estefania Claudio, Philip M Murphy, Rémy Bosselut, Ulrich Siebenlist

Publikováno v: PLoS Pathogens, Vol 17, Iss 1, p e1009249 (2021)

Bcl-3 is an atypical member of the IκB family that acts in the nucleus to modulate transcription of many NF-κB targets in a highly context-dependent manner. Accordingly, complete Bcl-3-/- mice have diverse defects in both innate and adaptive immune

Externí odkaz: https://doaj.org/article/ef2eb82acd264a7fb7589d5ab6025ba3

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Akademický článek

Single-Cell Profiling Defines Transcriptomic Signatures Specific to Tumor-Reactive versus Virus-Responsive CD4+ T Cells

Autor: Assaf Magen, Jia Nie, Thomas Ciucci, Samira Tamoutounour, Yongmei Zhao, Monika Mehta, Bao Tran, Dorian B. McGavern, Sridhar Hannenhalli, Rémy Bosselut

Publikováno v: Cell Reports, Vol 29, Iss 10, Pp 3019-3032.e6 (2019)

Summary: Most current tumor immunotherapy strategies leverage cytotoxic CD8+ T cells. Despite evidence for clinical potential of CD4+ tumor-infiltrating lymphocytes (TILs), their functional diversity limits our ability to harness their activity. Here

Externí odkaz: https://doaj.org/article/04c9bdd7b29d45548a6e374407be89a6

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Akademický článek

Control of Intra-Thymic αβ T Cell Selection and Maturation by H3K27 Methylation and Demethylation

Autor: Rémy Bosselut

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

In addition to transcription factor binding, the dynamics of DNA modifications (methylation) and chromatin structure are essential contributors to the control of transcription in eukaryotes. Research in the past few years has emphasized the importanc

Externí odkaz: https://doaj.org/article/d8d0780135204b86a9accfaeb330f209

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