Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Rémy Castellano"'
Autor:
Vladimir Laletin, Pierre-Louis Bernard, Camille Montersino, Yuji Yamanashi, Daniel Olive, Rémy Castellano, Geoffrey Guittard, Jacques A. Nunès
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Targeting intracellular inhibiting proteins has been revealed to be a promising strategy to improve CD8+ T cell anti-tumor efficacy. Here, we are focusing on intracellular inhibiting proteins specific to TCR signaling: DOK1 and DOK2 expresse
Externí odkaz:
https://doaj.org/article/e174b2b3812347648dc4451f697c6c33
Autor:
Raphael Leblanc, Rania Ghossoub, Armelle Goubard, Rémy Castellano, Joanna Fares, Luc Camoin, Stephane Audebert, Marielle Balzano, Berna Bou‐Tayeh, Cyril Fauriat, Norbert Vey, Sylvain Garciaz, Jean‐Paul Borg, Yves Collette, Michel Aurrand‐Lions, Guido David, Pascale Zimmermann
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract The crosstalk between cancer and stromal cells plays a critical role in tumor progression. Syntenin is a small scaffold protein involved in the regulation of intercellular communication that is emerging as a target for cancer therapy. Here,
Externí odkaz:
https://doaj.org/article/5e8657f967514eacb630da97c26abd79
Autor:
Abdennour Benloucif, Damien Meyer, Laure Balasse, Armelle Goubard, Lucile Danner, Ahlem Bouhlel, Rémy Castellano, Benjamin Guillet, Patrick Chames, Brigitte Kerfelec
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMesothelin (MSLN) is overexpressed in a wide variety of cancers with few therapeutic options and has recently emerged as an attractive target for cancer therapy, with a large number of approaches currently under preclinical and clinical i
Externí odkaz:
https://doaj.org/article/262bbe933e284b5b9bd890fcc4892a92
Autor:
Violette Azzoni, Julien Wicinski, Manon Macario, Martin Castagné, Pascal Finetti, Katerina Ambrosova, Célia D. Rouault, Arnaud Sergé, Anne Farina, Emilie Agavnian, Sergiu Coslet, Emmanuelle Josselin, Arnaud Guille, José Adelaide, Emmanouil Zacharioudakis, Rémy Castellano, Francois Bertucci, Daniel Birnbaum, Raphael Rodriguez, Emmanuelle Charafe-Jauffret, Christophe Ginestier
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-15 (2022)
Abstract Replication stress (RS) has a pivotal role in tumor initiation, progression, or therapeutic resistance. In this study, we depicted the mechanism of breast cancer stem cells’ (bCSCs) response to RS and its clinical implication. We demonstra
Externí odkaz:
https://doaj.org/article/41f1ef2e00194644a397b32092889d81
Autor:
Julie Piron, Stephane Betzi, Jessica Pastour, Audrey Restouin, Rémy Castellano, Yves Collette, Niklas Tysklind, Juliette Smith-Ravin, Fabienne Priam
Publikováno v:
PeerJ, Vol 10, p e13955 (2022)
Although marine sponges are known for their antimicrobial, antifungal and cytotoxic activity, very few studies have been carried out on endemic species of Martinique. Martinique is part of the Agoa Sanctuary, a marine protected area that includes the
Externí odkaz:
https://doaj.org/article/c6baee5e5c2d46a49ec3a7763d65d782
Autor:
Leonor Lopez Almeida, Michael Sebbagh, François Bertucci, Pascal Finetti, Julien Wicinski, Sylvie Marchetto, Rémy Castellano, Emmanuelle Josselin, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Jean-Paul Borg, Marie-Josée Santoni
Publikováno v:
Stem Cell Reports, Vol 11, Iss 5, Pp 1040-1050 (2018)
Summary: Tumor initiation, progression, and therapeutic resistance have been proposed to originate from a subset of tumor cells, cancer stem cells (CSCs). However, the current understanding of the mechanisms involved in their self-renewal and tumor i
Externí odkaz:
https://doaj.org/article/719bdd3e4c6a4ee98eed7cf72b140fc3
Autor:
Fabienne Lamballe, Fahmida Ahmad, Yaron Vinik, Olivier Castellanet, Fabrice Daian, Anna‐Katharina Müller, Ulrike A. Köhler, Anne‐Laure Bailly, Emmanuelle Josselin, Rémy Castellano, Christelle Cayrou, Emmanuelle Charafe‐Jauffret, Gordon B. Mills, Vincent Géli, Jean‐Paul Borg, Sima Lev, Flavio Maina
Publikováno v:
Advanced Science, Vol 8, Iss 3, Pp n/a-n/a (2021)
Abstract Triple‐negative breast cancer (TNBC) is a highly aggressive breast cancer subtype characterized by a remarkable molecular heterogeneity. Currently, there are no effective druggable targets and advanced preclinical models of the human disea
Externí odkaz:
https://doaj.org/article/fdcfab7683c2492fb8717fe04289a634
Autor:
Abir Arfaoui, Claire Rioualen, Violette Azzoni, Guillaume Pinna, Pascal Finetti, Julien Wicinski, Emmanuelle Josselin, Manon Macario, Rémy Castellano, Candi Léonard‐Stumpf, Anthony Bal, Abigaelle Gros, Sylvain Lossy, Maher Kharrat, Yves Collette, Francois Bertucci, Daniel Birnbaum, Hayet Douik, Ghislain Bidaut, Emmanuelle Charafe‐Jauffret, Christophe Ginestier
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp n/a-n/a (2019)
Abstract Therapeutic resistance is a major clinical challenge in oncology. Evidence identifies cancer stem cells (CSCs) as a driver of tumor evolution. Accordingly, the key stemness property unique to CSCs may represent a reservoir of therapeutic tar
Externí odkaz:
https://doaj.org/article/c9002abaa4bb472dafea9936d6b75e8c
Autor:
Joanie Del Bano, Rémy Florès-Florès, Emmanuelle Josselin, Armelle Goubard, Laetitia Ganier, Rémy Castellano, Patrick Chames, Daniel Baty, Brigitte Kerfelec
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Triple negative breast cancers (TNBC) remain a major medical challenge due to poor prognosis and limited treatment options. Mesothelin is a glycosyl-phosphatidyl inositol-linked membrane protein with restricted normal expression and high level expres
Externí odkaz:
https://doaj.org/article/e903097211f846678847b4f060e65053
Autor:
Esma Karkeni, Stéphanie O. Morin, Berna Bou Tayeh, Armelle Goubard, Emmanuelle Josselin, Rémy Castellano, Cyril Fauriat, Geoffrey Guittard, Daniel Olive, Jacques A. Nunès
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Women with low levels of vitamin D have a higher risk of developing breast cancer. Numerous studies associated the presence of a CD8+ T cell infiltration with a good prognosis. As vitamin D may play a key role in the modulation of the immune system,
Externí odkaz:
https://doaj.org/article/cd15c40f262c44d5a7df9375f3e9fdac